1. Early Telomerase Inactivation Accelerates Aging Independently of Telomere Length

    Cell 160(5):928 (2015)

    Telomerase is required for long-term telomere maintenance and protection. Using single budding yeast mother cell analyses we found that, even early after telomerase inactivation (ETI), yeast mother cells show transient DNA damage response (DDR) episodes, stochastically altered cell-cyc...
  2. Early telomerase inactivation accelerates aging independently of telomere length.

    Cell 160(5):928 (2015) PMID 25723167

    Telomerase is required for long-term telomere maintenance and protection. Using single budding yeast mother cell analyses we found that, even early after telomerase inactivation (ETI), yeast mother cells show transient DNA damage response (DDR) episodes, stochastically altered cell-cycle dynamic...
  3. Early telomerase inactivation accelerates aging independently of telomere length.

    Cell 160(5):928 (2015) PMID 25723167 PMCID PMC4496004

    Telomerase is required for long-term telomere maintenance and protection. Using single budding yeast mother cell analyses we found that, even early after telomerase inactivation (ETI), yeast mother cells show transient DNA damage response (DDR) episodes, stochastically altered cell-cycle dynamic...
  4. Early Telomerase Inactivation Accelerates Aging Independently of Telomere Length

    Cell (2014)

    Telomerase is required for long-term telomere maintenance and protection. Using single budding yeast mother cell analyses we found that, even Early after Telomerase Inactivation (ETI), yeast mother cells show transient DNA Damage Response (DDR) episodes, stochastically altered cell cyc...
  5. CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes

    Cell 154(2):442 (2013)

    The genetic interrogation and reprogramming of cells requires methods for robust and precise targeting of genes for expression or repression. The CRISPR-associated catalytically inactive dCas9 protein offers a general platform for RNA-guided DNA targeting. Here, we show that fusion of ...
  6. CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes.

    Cell 154(2):442 (2013) PMID 23849981 PMCID PMC3770145

    The genetic interrogation and reprogramming of cells requires methods for robust and precise targeting of genes for expression or repression. The CRISPR-associated catalytically inactive dCas9 protein offers a general platform for RNA-guided DNA targeting. Here, we show that fusion of dCas9 to e...
  7. CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes

    Cell 154(2):442 (2013) PMID 23849981 PMCID PMC3770145

    The genetic interrogation and reprogramming of cells requires methods for robust and precise targeting of genes for expression or repression. The CRISPR-associated catalytically inactive dCas9 protein offers a general platform for RNA-guided DNA targeting. Here, we show that fusion of ...
  8. Early Telomerase Inactivation Accelerates Aging Independently of Telomere Length

    Cell (2001)

    Telomerase is required for long-term telomere maintenance and protection. Using single budding yeast mother cell analyses we found that, even early after telomerase inactivation (ETI), yeast mother cells show transient DNA damage response (DDR) episodes, stochastically altered cell-cyc...
  9. Early Telomerase Inactivation Accelerates Aging Independently of Telomere Length

    Cell (2001)

    Telomerase is required for long-term telomere maintenance and protection. Using single budding yeast mother cell analyses we found that, even early after telomerase inactivation (ETI), yeast mother cells show transient DNA damage response (DDR) episodes, stochastically altered cell-cyc...
  10. Early Telomerase Inactivation Accelerates Aging Independently of Telomere Length

    Cell (2001)

    Telomerase is required for long-term telomere maintenance and protection. Using single budding yeast mother cell analyses we found that, even early after telomerase inactivation (ETI), yeast mother cells show transient DNA damage response (DDR) episodes, stochastically altered cell-cyc...