1. Sensory detection of food rapidly modulates arcuate feeding circuits.

    Cell 160(5):829 (2015) PMID 25703096

    Hunger is controlled by specialized neural circuits that translate homeostatic needs into motivated behaviors. These circuits are under chronic control by circulating signals of nutritional state, but their rapid dynamics on the timescale of behavior remain unknown. Here, we report optical recor...
  2. Sensory Detection of Food Rapidly Modulates Arcuate Feeding Circuits

    Cell 160(5):829 (2015)

    Hunger is controlled by specialized neural circuits that translate homeostatic needs into motivated behaviors. These circuits are under chronic control by circulating signals of nutritional state, but their rapid dynamics on the timescale of behavior remain unknown. Here, we report opt...
  3. Sensory detection of food rapidly modulates arcuate feeding circuits.

    Cell 160(5):829 (2015) PMID 25703096

    Hunger is controlled by specialized neural circuits that translate homeostatic needs into motivated behaviors. These circuits are under chronic control by circulating signals of nutritional state, but their rapid dynamics on the timescale of behavior remain unknown. Here, we report optical recor...
  4. Ablation of AgRP neurons impairs adaption to restricted feeding.

    Molecular Metabolism 3(7):694 (2014) PMID 25352998 PMCID PMC4209355

    While the SCN controls the circadian clock, further evidence suggests the existence of a food-entrainable oscillator (FEO) that links behavior to changes in food availability such as during restricted feeding (RF). We found that the activity of AgRP/NPY neurons changed rhythmically during RF sug...
  5. Ablation of AgRP neurons impairs adaption to restricted feeding

    Molecular Metabolism (2014)

    While the SCN controls the circadian clock, further evidence suggests the existence of a food-entrainable oscillator (FEO) that links behavior to changes in food availability such as during restricted feeding (RF). We found that the activity of AgRP/NPY neurons changed rhythmically dur...
  6. Molecular Profiling of Neurons Based on Connectivity

    Cell 157(5):1230 (2014)

    The complexity and cellular heterogeneity of neural circuitry presents a major challenge to understanding the role of discrete neural populations in controlling behavior. While neuroanatomical methods enable high-resolution mapping of neural circuitry, these approaches do not allow sys...
  7. Molecular profiling of neurons based on connectivity.

    Cell 157(5):1230 (2014) PMID 24855954

    The complexity and cellular heterogeneity of neural circuitry presents a major challenge to understanding the role of discrete neural populations in controlling behavior. While neuroanatomical methods enable high-resolution mapping of neural circuitry, these approaches do not allow systematic mo...
  8. A critical role for mTORC1 in erythropoiesis and anemia.

    eLife 3:e01913 (2014) PMID 25201874 PMCID PMC4179304

    Red blood cells (RBC) must coordinate their rate of growth and proliferation with the availability of nutrients, such as iron, but the signaling mechanisms that link the nutritional state to RBC growth are incompletely understood. We performed a screen for cell types that have high levels of sig...
  9. A critical role for mTORC1 in erythropoiesis and anemia.

    eLife 3:e01913 (2014) PMID 25201874 PMCID PMC4179304

    Red blood cells (RBC) must coordinate their rate of growth and proliferation with the availability of nutrients, such as iron, but the signaling mechanisms that link the nutritional state to RBC growth are incompletely understood. We performed a screen for cell types that have high levels of sig...
  10. Molecular Profiling of Activated Neurons by Phosphorylated Ribosome Capture

    Cell 151(5):1126 (2012)

    The mammalian brain is composed of thousands of interacting neural cell types. Systematic approaches to establish the molecular identity of functional populations of neurons would advance our understanding of neural mechanisms controlling behavior. Here, we show that ribosomal protein ...
  11. Molecular profiling of activated neurons by phosphorylated ribosome capture.

    Cell 151(5):1126 (2012) PMID 23178128 PMCID PMC3839252

    The mammalian brain is composed of thousands of interacting neural cell types. Systematic approaches to establish the molecular identity of functional populations of neurons would advance our understanding of neural mechanisms controlling behavior. Here, we show that ribosomal protein S6, a stru...
  12. For a PDK1 inhibitor, the substrate matters.

    Biochemical Journal 433(2):e1 (2011) PMID 21175429

    More than 20 protein kinases are directly activated by 3-phosphoinositide-dependent kinase 1 (PDK1), which is a central component of the pathways that regulate cell growth, proliferation and survival. Despite the importance of PDK1 in cell signalling, highly selective PDK1 inhibitors have not be...
  13. For a PDK1 inhibitor, the substrate matters.

    Biochemical Journal 433(2):e1 (2011) PMID 21175429

    More than 20 protein kinases are directly activated by 3-phosphoinositide-dependent kinase 1 (PDK1), which is a central component of the pathways that regulate cell growth, proliferation and survival. Despite the importance of PDK1 in cell signalling, highly selective PDK1 inhibitors have not be...
  14. Discovery of dual inhibitors of the immune cell PI3Ks p110delta and p110gamma: a prototype for new anti-inflammatory drugs.

    Chemistry & Biology 17(2):123 (2010) PMID 20189103 PMCID PMC2858875

    PI3Kdelta and PI3Kgamma regulate immune cell signaling, while the related PI3Kalpha and PI3Kbeta regulate cell survival and metabolism. Selective inhibitors of PI3Kdelta/gamma represent a potential class of anti-inflammatory agents lacking the antiproliferative effects associated with PI3Kalpha/...
  15. Discovery of dual inhibitors of the immune cell PI3Ks p110delta and p110gamma: a prototype for new anti-inflammatory drugs.

    Chemistry & Biology 17(2):123 (2010) PMID 20189103 PMCID PMC2858875

    PI3Kdelta and PI3Kgamma regulate immune cell signaling, while the related PI3Kalpha and PI3Kbeta regulate cell survival and metabolism. Selective inhibitors of PI3Kdelta/gamma represent a potential class of anti-inflammatory agents lacking the antiproliferative effects associated with PI3Kalpha/...
  16. Targeting the cancer kinome through polypharmacology.

    Nature Reviews: Cancer 10(2):130 (2010) PMID 20094047 PMCID PMC2880454

    Kinase inhibitors are the largest class of new cancer drugs. However, it is already apparent that most tumours can escape from the inhibition of any single kinase. If it is necessary to inhibit multiple kinases, how do we choose which ones? In this Opinion article, we discuss some of the strateg...
  17. Targeting the cancer kinome through polypharmacology.

    Nature Reviews: Cancer 10(2):130 (2010) PMID 20094047 PMCID PMC2880454

    Kinase inhibitors are the largest class of new cancer drugs. However, it is already apparent that most tumours can escape from the inhibition of any single kinase. If it is necessary to inhibit multiple kinases, how do we choose which ones? In this Opinion article, we discuss some of the strateg...
  18. Hyperleptinemia is required for the development of leptin resistance.

    PLoS ONE 5(6):e11376 (2010) PMID 20613882 PMCID PMC2894068

    Leptin regulates body weight by signaling to the brain the availability of energy stored as fat. This negative feedback loop becomes disrupted in most obese individuals, resulting in a state known as leptin resistance. The physiological causes of leptin resistance remain poorly understood. Here ...
  19. Small molecule inhibitors of the PI3-kinase family.

    Current Topics in Microbiology and Immunology 347:263 (2010) PMID 20473788

    The PI3-K family is one of the most intensely pursued classes of drug targets. This chapter reviews some of the chemical and structural features that determine the selectivity of PI3-K inhibitors, by focusing on a few key compounds that have been instrumental in guiding our understanding of how ...
  20. Discovery of Dual Inhibitors of the Immune Cell PI3Ks p110δ and p110γ: a Prototype for New Anti-inflammatory Drugs

    Chemistry & Biology 17(2):123 (2010)

    PI3Kδ and PI3Kγ regulate immune cell signaling, while the related PI3Kα and PI3Kβ regulate cell survival and metabolism. Selective inhibitors of PI3Kδ/γ represent a potential class of anti-inflammatory agents lacking the antiproliferative effects associated with PI3Kα/β inhibition. Here we ...