1. An Influenza Virus M2 Protein Specific Chimeric Antigen Receptor Modulates Influenza A/WSN/33 H1N1 Infection In Vivo.

    Open Virology Journal 7:28 (2013) PMID 23493233 PMCID PMC3594705

    A potential target for the development of universal vaccine strategies against Influenza A is the M2 protein - a membrane protein with a highly conserved extracellular domain. In this study we developed engineered T-cell receptors, by fusing M2-specific antibody sequences with T-cell receptor tr...
  2. A novel family of peptides with potent activity against influenza A viruses.

    Journal of General Virology 93(Pt 5):980 (2012) PMID 22258859

    The emergence of drug-resistant strains of influenza virus has catalysed a search for new antiviral agents to supplement or replace existing drugs. Following the success of the human immunodeficiency virus entry blocker Enfuvirtide, there has been a resurgence of interest in peptide-based antivi...
  3. Behaviour of influenza A viruses differentially expressing segment 2 gene products in vitro and in vivo.

    Journal of General Virology 93(Pt 4):840 (2012) PMID 22190016

    The influenza A virus genome comprises eight segments of negative-sense RNA that encode up to 12 proteins. RNA segment 2 encodes three proteins, PB1, PB1-F2 and N40, that are translated from the same mRNA by ribosomal leaky scanning and reinitiation. PB1 is a subunit of the trimeric viral RNA po...
  4. A novel Cre recombinase imaging system for tracking lymphotropic virus infection in vivo.

    PLoS ONE 4(8):e6492 (2009) PMID 19652715 PMCID PMC2714982

    Detection, isolation, and identification of individual virus infected cells during long term infection are critical to advance our understanding of mechanisms of pathogenesis for latent/persistent viruses. However, current approaches to study these viruses in vivo have been hampered by low sensi...
  5. The M4 gene of murine gammaherpesvirus 68 modulates latent infection.

    Journal of General Virology 87(Pt 4):803 (2006) PMID 16528028

    Murine gammaherpesvirus 68 (MHV-68) encodes a set of unique genes, M1, M2, M3 and M4, and eight non-translated tRNA-like molecules that are thought to be important in virus-host interactions and latent infection. The M4 gene is predicted to encode a novel secreted protein. To investigate the rol...