1. Administration of progranulin (PGRN) triggers ER stress and impairs insulin sensitivity via PERK-eIF2α-dependent manner.

    Cell Cycle 14(12):1893 (2015) PMID 26039714

    Progranulin (PGRN) has recently emerged as an important regulator for glucose metabolism and insulin sensitivity. However, the direct effects of PGRN in vivo and the underlying mechanisms between PGRN and impaired insulin sensitivity are not fully understood. In this study, mice treated with PGR...
  2. Editorial: IUTAM 2013

    International Journal of Impact Engineering 79:2 (2015)

  3. Effect of Astragalus polysaccharide and its sulfated derivative on growth performance and immune condition of lipopolysaccharide-treated broilers.

    International Journal of Biological Macromolecules 76:188 (2015) PMID 25748840

    This study evaluates the immunomodulating activities of Astragalus polysaccharide (APS) and sulfated APS (SAPS) in LPS-infected broiler chicks. SAPS was derived using the classic chlorosulfonic acid-pyridine method. On day 16, the birds were injected intramuscularly with 0.5 mL of either saline,...
  4. SnapShot: Origins of DNA replication.

    Cell 161(2):418 (2015) PMID 25860614

    The fundamental unit of DNA replication, the replicon, is governed by a cis-acting replicator sequence and a trans-activating initiator factor. Despite the increased size and complexity of eukaryotic genomes, eukaryotic DNA replication continues to be guided by the fundamental principles and con...
  5. Experimental study of waste concentration by mechanical vapor compression technology

    Desalination 361:46 (2015)

    To study the concentration characteristics of mechanical vapor compression (MVC) technology on the wastewater concentration process, a single-effect MVC system for concentrating dimethylacetamide wastewater was investigated. The performance of the MVC experimental system was evaluated ...
  6. Developments of high strength Bi-containing Sn0.7Cu lead-free solder alloys prepared by directional solidification

    Journal of Alloys and Compounds 625:241 (2015)

    • The Sn0.7Cu–xBi solder alloys were directionally solidified. • Both spacing and diameter of fibers decreased with increasing solidification rate. ...
  7. Protein mutated in paroxysmal dyskinesia interacts with the active zone protein RIM and suppresses synaptic vesicle exocytosis.

    PNAS 112(10):2935 (2015) PMID 25730884

    Paroxysmal nonkinesigenic dyskinesia (PNKD) is an autosomal dominant episodic movement disorder precipitated by coffee, alcohol, and stress. We previously identified the causative gene but the function of the encoded protein remains unknown. We also generated a PNKD mouse model that revealed dys...
  8. Protein mutated in paroxysmal dyskinesia interacts with the active zone protein RIM and suppresses synaptic vesicle exocytosis.

    PNAS 112(10):2935 (2015) PMID 25730884 PMCID PMC4364199

    Paroxysmal nonkinesigenic dyskinesia (PNKD) is an autosomal dominant episodic movement disorder precipitated by coffee, alcohol, and stress. We previously identified the causative gene but the function of the encoded protein remains unknown. We also generated a PNKD mouse model that revealed dys...
  9. Dynamic loading and redistribution of the Mcm2-7 helicase complex through the cell cycle.

    EMBO Journal 34(4):531 (2015) PMID 25555795

    Eukaryotic replication origins are defined by the ORC-dependent loading of the Mcm2-7 helicase complex onto chromatin in G1. Paradoxically, there is a vast excess of Mcm2-7 relative to ORC assembled onto chromatin in G1. These excess Mcm2-7 complexes exhibit little co-localization with ORC or re...
  10. Dynamic loading and redistribution of the Mcm2-7 helicase complex through the cell cycle.

    EMBO Journal 34(4):531 (2015) PMID 25555795 PMCID PMC4331006

    Eukaryotic replication origins are defined by the ORC-dependent loading of the Mcm2-7 helicase complex onto chromatin in G1. Paradoxically, there is a vast excess of Mcm2-7 relative to ORC assembled onto chromatin in G1. These excess Mcm2-7 complexes exhibit little co-localization with ORC or re...
  11. Dynamic loading and redistribution of the Mcm2-7 helicase complex through the cell cycle.

    EMBO Journal 34(4):531 (2015) PMID 25555795 PMCID PMC4331006

    Eukaryotic replication origins are defined by the ORC-dependent loading of the Mcm2-7 helicase complex onto chromatin in G1. Paradoxically, there is a vast excess of Mcm2-7 relative to ORC assembled onto chromatin in G1. These excess Mcm2-7 complexes exhibit little co-localization with ORC or re...
  12. Pretreatment of cyanided tailings by catalytic ozonation with Mn2 +/O3

    Journal of Environmental Sciences 28:14 (2015)

    The increasing amount of cyanided tailings produced as a by-product has gained significant attention in recent years because of the rapid development of the gold industry and extensive exploitation of gold mineral resources. The effective use of these secondary resources is becoming an...
  13. Pretreatment of cyanided tailings by catalytic ozonation with Mn(2+)/O(3.).

    Journal of Environmental Sciences 28:14 (2015) PMID 25662233

    The increasing amount of cyanided tailings produced as a by-product has gained significant attention in recent years because of the rapid development of the gold industry and extensive exploitation of gold mineral resources. The effective use of these secondary resources is becoming an important...
  14. Pretreatment of cyanided tailings by catalytic ozonation with Mn2+/O3.

    Journal of Environmental Sciences 28:14 (2015) PMID 25662233

    The increasing amount of cyanided tailings produced as a by-product has gained significant attention in recent years because of the rapid development of the gold industry and extensive exploitation of gold mineral resources. The effective use of these secondary resources is becoming an important...
  15. Selective Generation of Dopaminergic Precursors from Mouse Fibroblasts by Direct Lineage Conversion.

    Scientific reports 5:12622 (2015) PMID 26224135

    Degeneration of midbrain dopaminergic (DA) neurons is a key pathological event of Parkinson's disease (PD). Limited adult dopaminergic neurogenesis has led to novel therapeutic strategies such as transplantation of dopaminergic precursors (DPs). However, this strategy is currently restrained by ...
  16. Systemic application of teriparatide for steroid induced osteonecrosis in a rat model.

    BMC Musculoskeletal Disorders 16:163 (2015) PMID 26163144 PMCID PMC4499203

    Steroid associated osteonecrosis is difficult to treat. Teriparatide, as the only one bone anabolic drug, has achieved very promising effect in osteoporosis and other bone skeletal diseases. We carried out this animal study to evaluate the effect of subcutaneous injection of teriparatide for the...
  17. Using a novel microRNA delivery system to inhibit osteoclastogenesis.

    International Journal of Molecular Sciences 16(4):8337 (2015) PMID 25874760 PMCID PMC4425084

    Previously, we developed a novel microRNA (miRNA) delivery system based on bacteriophage MS2 virus-like particles (MS2 VLPs). In this current study, we used this system to transport miR-146a into human peripheral blood mononuclear cells (PBMCs), and demonstrated the inhibition of osteoclastogene...
  18. Capillary encapsulating of fiber Bragg grating and the associated sensing model

    Optics Communications 333:92 (2014)

    In order to enhance temperature sensitivity of the bare fiber Bragg grating (FBG), a capillary encapsulating method was developed. The mechanism of temperature sensitivity enhancing was formularized based on the analysis of the thermal stress, a temperature sensing model of the encapsu...
  19. Results of first proficiency test for KRAS testing with formalin-fixed, paraffin-embedded cell lines in China.

    Clinical Chemistry and Laboratory Medicine 52(12):1851 (2014) PMID 24945428

    Abstract Background: Laboratory testing for KRAS (v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog) mutations in metastatic colorectal cancer (mCRC) is performed by various methods in China, but there is no standardized system for proficiency testing or assay performance evaluations. The aim...
  20. On the high strain rate behavior of 63–37 Sn–Pb eutectic solders with temperature effects

    International Journal of Impact Engineering 74:126 (2014)

    This study presents experimental results performed on samples of Eutectic solder material (63 wt. % Sn 37 wt. % Pb) loaded at high strain rates and elevated temperatures. The tests were performed at high strain rates using Split Hopkinson Pressure Bar (SHPB). The strain rates were in t...