1. Profiling of the dynamically alteredgene expression in peripheral nerve injury using NGS RNA sequencing technique.

    American journal of translational research 8(2):871 (2016) PMID 27158375 PMCID PMC4846932

    Functional recovery of peripheral nerve injuries is of major demand in clinical practice worldwide. Although, to some extent, peripheral nervous system can spontaneously regenerate, post-injury recovery is often associated with poor functional outcome. The molecular mechanism controlling the per...
  2. Collateral development and spinal motor reorganization after nerve injury and repair.

    American journal of translational research 8(7):2897 (2016) PMID 27508011 PMCID PMC4969427

    Functional recovery is often unsatisfactory after severe extended nerve defects or proximal nerve trunks injuries repaired by traditional repair methods, as the long regeneration distance for the regenerated axons to reinnervate their original target end-organs. The proximal nerve stump can rege...
  3. Peripheral nerve mutilation through biodegradable conduit small gap tubulisation: a multicentre randomised trial

    The Lancet 386:S40 (2015)

    Background Although peripheral nerve injury is repaired by ingenious epineurial neurorrhaphy, functional recovery is usually not satisfactory and is hindered by many factors, including the misconnections of sensory and motor nerve fibres, difficulties in target organ reinnerv...
  4. Changes and trends of pre-hospital emergency disease spectrum in Beijing in 2003–12: a retrospective study

    The Lancet 386:S39 (2015)

    Background Pre-hospital emergency call is a crucial indicator of emergency disease spectrum. Since Beijing has changed substantially in economy and population, analysis of the trend of the emergency disease spectrum can greatly contribute to pre-hospital emergency planning. ...
  5. Road traffic injury and rescue system in China.

    The Lancet 385(9978):1622 (2015) PMID 25943819

  6. Motor function recovery during peripheral nerve multiple regeneration.

    Journal Of Tissue Engineering And Regenerative ... 9(4):415 (2015) PMID 24323657

    Neuronal functional compensation and multiple regenerating axon sprouting occur during peripheral nerve regeneration. Sprouting nerve buds were quantitatively maintained and had matured when multiple injured distal nerves were anastomosed to smaller number of proximal nerve stumps; this has posi...
  7. Specificity of motor axon regeneration: a comparison of recovery following biodegradable conduit small gap tubulization and epineurial neurorrhaphy.

    American journal of translational research 7(1):53 (2015) PMID 25755828 PMCID PMC4346523

    Functional recovery is often unsatisfactory after lesions in the peripheral nervous system despite the strong potential for regeneration and advances in microsurgical techniques. Axonal regeneration in mixed nerve into inappropriate pathways is a major contributing factor to this failure. In thi...
  8. Early sensory protection in reverse end-to-side neurorrhaphy to improve the functional recovery of chronically denervated muscle in rat: a pilot study.

    Journal of Neurosurgery 121(2):415 (2014) PMID 24878291

    Early innervation by sensory nerves has been proposed to prevent atrophy of chronically denervated muscle, but conventional end-to-end (ETE) neurorrhaphy has been demonstrated to have adverse effects on muscle contractile function. The aim of the present study was to investigate the potential fo...
  9. Improved peripheral nerve regeneration with sustained release nerve growth factor microspheres in small gap tubulization.

    American journal of translational research 6(4):413 (2014) PMID 25075258 PMCID PMC4113503

    To evaluate the long-term results of the use of nerve growth factor (NGF)-loaded poly-D, L-lactide-co-glycolide (PLGA) microspheres for improve nerve regeneration with small gap tubulization. NGF microspheres were prepared by a modified W/O/W emulsion solvent evaporation method. Forty-eight male...
  10. Electrical stimulation promotes regeneration of defective peripheral nerves after delayed repair intervals lasting under one month.

    PLoS ONE 9(9):e105045 (2014) PMID 25181499 PMCID PMC4152131

    Electrical stimulation (ES) has been proven to be an effective means of enhancing the speed and accuracy of nerve regeneration. However, these results were recorded when the procedure was performed almost immediately after nerve injury. In clinical settings, most patients cannot be treated immed...
  11. Comparison of road traffic injury characteristics between local versus floating migrant patients in a tertiary hospital between 2007 and 2010.

    PLoS ONE 9(1):e82640 (2014) PMID 24475023 PMCID PMC3903469

    The aim of this study is to give a description of the road traffic injuries (RTIs) characteristics of floating migrant population by comparing with those of local residents in a harbor city of China. A population-based descriptive study was carried out between 2007 and 2010 with RTI patient reco...
  12. Role of lumbricus extract in the nerve amplification effect during peripheral nerve regeneration.

    American journal of translational research 6(6):876 (2014) PMID 25628798 PMCID PMC4297355

    Among the methods of the peripheral nerve repair, artificial conduit bridging surgery is superior to epineurium and perineurium neurorrhaphy because of supplying enough space for nerve regeneration. Artificial conduit provides important microenvironment for peripheral nerve regeneration, especia...
  13. Small gap sleeve bridging can improve the accuracy of peripheral nerve selective regeneration.

    Artificial Cells, Nanomedicine and Biotechnology 41(6):402 (2013) PMID 23336675

    The pure motor peripheral nerves animal model, obtained by ablating the dorsal root ganglions (DRGs), was used to investigate the accuracy of peripheral nerve selective regeneration using small gap sleeve bridging compared to epineurium neurorrhaphy. The results showed that the number of imprope...
  14. The effect of a small gap sleeve suture at the distal anastomosis of a nerve graft on promoting nerve regeneration and functional recovery.

    Artificial Cells, Nanomedicine and Biotechnology 41(4):282 (2013) PMID 23316870

    The effect of a small gap sleeve suture at the distal anastomosis of a nerve graft on promoting nerve regeneration and functional recovery was investigated by experimental observation. The model of common peroneal nerve defect in Sprague-Dawley (SD) rats was established, and an autologous sural ...
  15. Epimedium extract promotes peripheral nerve regeneration in rats.

    Evidence-based Complementary and Alternative Me... 2013:954798 (2013) PMID 24159356 PMCID PMC3789416

    Effects of Epimedium extract and its constituent icariin on peripheral nerve repair were investigated in a crush injury rat model. Animals were divided into four groups: sham, control, Epimedium extract, and icariin groups. At postoperative weeks 1, 2, 4, and 8, nerve regeneration and functional...
  16. Biodegradable conduit small gap tubulization for peripheral nerve mutilation: a substitute for traditional epineurial neurorrhaphy.

    International journal of medical sciences 10(2):171 (2013) PMID 23329889 PMCID PMC3547215

    Nerve regeneration and re-innervation are usually difficult after peripheral nerve injury. Epineurium neurorrhaphy to recover the nerve continuity is the traditional choice of peripheral nerve mutilation without nerve defects, whereas the functional recovery remains quite unsatisfactory. Based o...
  17. Hedysari extract improves regeneration after peripheral nerve injury by enhancing the amplification effect.

    PLoS ONE 8(7):e67921 (2013) PMID 23844128 PMCID PMC3700897

    Radix Hedysari is an herbal preparation frequently used in traditional Chinese medicine. It can promote regeneration after peripheral nerve injury, but its effect on the amplification ratio (the ratio of distal to proximal fibers) during peripheral nerve regeneration has not yet been examined. I...
  18. Characteristics of peripheral nerve regeneration following a second nerve injury and repair.

    Artificial Cells, Blood Substitutes and Biotech... 40(4):296 (2012) PMID 22384852

    During the process of peripheral nerve regeneration, a single neuron can regenerate and maintain more than one collateral in a regenerative distal stump. Furthermore, some of the new shoots can mature gradually through remyelination and grow into the remote target organ to play a physiological f...
  19. Efficient synthesis of copillar[5]arenes and their host-guest properties with dibromoalkanes.

    Organic & Biomolecular Chemistry 9(20):7007 (2011) PMID 21870001

    An efficient method for the synthesis of copillar[5]arenes was developed with FeCl(3) as catalyst and different 1,4-dialkoxybenzenes and paraformaldehyde as reactants (yields: 50-85%). The host-guest property of (co)pillar[5]arenes and terminal dibromoalkanes was investigated by (1)H NMR measure...
  20. Influence of different distal nerve degeneration period on peripheral nerve collateral sprouts regeneration.

    Artificial Cells, Blood Substitutes and Biotech... 39(4):223 (2011) PMID 21117869

    The effects of the distal nerve degeneration on the regeneration of the collateral sprouts from the proximal nerve stump have been examined. The delayed cross-suture anastomosis technique was used in which the tibial nerve was denervated for 0-8 weeks before cross-suture of the freshly axotomize...