Intratumoral oxygen gradients mediate sarcoma cell invasion.
PNAS 113(33):9292 (2016)
Hypoxia is a critical factor in the progression and metastasis of many cancers, including soft tissue sarcomas. Frequently, oxygen (O2) gradients develop in tumors as they grow beyond their vascular supply, leading to heterogeneous areas of O2 depletion. Here, we report the impact of hypoxic O2 ...
Circulating Prolactin and Risk of Type 2 Diabetes: A Prospective Study.
American Journal of Epidemiology 184(4):295 (2016)
Prolactin plays an important role in maintaining a normal glucose homeostasis during pregnancy and beyond. Studies investigating the association between prolactin and type 2 diabetes beyond pregnancy are rare and none is prospective. We aimed to examine whether prolactin associates with type 2 d...
Layered bismuth oxyhalide nanomaterials for highly efficient tumor photodynamic therapy.
Nanoscale 8(25):12715 (2016)
Layered bismuth oxyhalide nanomaterials have received much more interest as promising photocatalysts because of their unique layered structures and high photocatalytic performance, which can be used as potential inorganic photosensitizers in tumor photodynamic therapy (PDT). In recent years, pho...
Correction: Layered bismuth oxyhalide nanomaterials for highly efficient tumor photodynamic therapy.
Nanoscale 8(25):12844 (2016)
Correction for 'Layered bismuth oxyhalide nanomaterials for highly efficient tumor photodynamic therapy' by Yu Xu, et al., Nanoscale, 2016, DOI: 10.1039/c5nr04540a.
Deep sequencing of the MHC region in the Chinese population contributes to studies of complex disease.
Nature Genetics 48(7):740 (2016)
The human major histocompatibility complex (MHC) region has been shown to be associated with numerous diseases. However, it remains a challenge to pinpoint the causal variants for these associations because of the extreme complexity of the region. We thus sequenced the entire 5-Mb MHC region in ...
MicroRNA-23b regulates nasopharyngeal carcinoma cell proliferation and metastasis by targeting E-cadherin.
Molecular Medicine Reports 14(1):537 (2016)
MicroRNA-23b (miR-23b) is important in tumor proliferation and metastasis. In this study, it was suggested that the levels of miR-23b were increased in nasopharyngeal carcinoma (NPC) tissues compared with the adjacent normal tissues. The present study aimed to explore the role of miR‑23b upregul...
The whole mitochondrial genome of the Lesser Kestrel (Falco naumanni).
Mitochondrial DNA Part A 27(4):2385 (2016)
Falconiformes include most of the predatory birds, they play crucial role in maintaining the balance of ecology system. To further illustrate the phylogenetic status for the species of Falconiformes, the entire mitochondrial DNA (mtDNA) genome of Falco naumanni was amplified and sequenced, furth...
Impact of Age on the Prognosis of Operable Gastric Cancer Patients: An Analysis Based on SEER Database.
Medicine (Baltimore) 95(24):e3944 (2016)
To investigate the impact of age on the clinicopathological features and survival of patients with gastric cancer (GC), and hope to better define age-specific patterns of GC and possible associated risk factors.Using the surveillance, epidemiology, and end results (SEER) database to search the p...
Plasma glucose and hemoglobin A1c for the detection of diabetes in Chinese adults.
Journal Of Diabetes 8(3):378 (2016)
The aim of the present study was to evaluate the performance of plasma glucose (PG) and HbA1c for the detection of diabetes in the general population in China.
A cross-sectional analysis was conducted in a nationally representative sample of 98,658 Chinese adults aged ≥18 years. Fasting plasma g...
Complete mitochondrial genome of Chinese bamboo rat, Rhizomys sinensis and species divergence comparison.
Mitochondrial DNA Part A 27(3):1773 (2016)
The Chinese bamboo rat Rhizomys sinensis belongs to family Spalacidae, and is distributed in China, Myanmar, and Vietnam. In this study, the entire mitochondrial genome of R. sinensis was firstly determined. The genome is 16,564 bases in length, containing 13 protein coding genes, 22 transfer RN...
Mitochondrial DNA Haplogroup A may confer a genetic susceptibility to AIDS group from Southwest China.
Mitochondrial DNA Part A 27(3):2221 (2016)
The acquired immunodeficiency syndrome (AIDS) in humans was one of the chronic infections caused by human immunodeficiency virus (HIV), and the interactions between viral infection and mitochondrial energetic implicated that mitochondrial DNA (mtDNA) variation(s) may effect genetic susceptibilit...
Description of the mitogenome of Gansu mole (Scapanulus oweni).
Mitochondrial DNA Part A 27(3):2083 (2016)
The Gansu mole Scapanulus oweni belongs to family Talpidae, and is distributed in the Central and Southwest China. In this study, the total mitochondrial genome of S. oweni was firstly determined. The genome is 16,826 bases in length and contains 13 protein-coding genes, 22 transfer RNA genes, 2...
Knockdown of asparagine synthetase by RNAi suppresses cell growth in human melanoma cells and epidermoid carcinoma cells.
Biotechnology and Applied Biochemistry 63(3):328 (2016)
Melanoma, the most aggressive form of skin cancer, causes more than 40,000 deaths each year worldwide. And epidermoid carcinoma is another major form of skin cancer, which could be studied together with melanoma in several aspects. Asparagine synthetase (ASNS) gene encodes an enzyme that catalyz...
Type 2 Diabetes, Diabetes Genetic Score and Risk of Decreased Renal Function and Albuminuria: A Mendelian Randomization Study.
EBioMedicine 6:162 (2016)
Type 2 diabetes (T2D) is a risk factor for dysregulation of glomerular filtration rate (GFR) and albuminuria. However, whether the association is causal remains unestablished.
We performed a Mendelian Randomization (MR) analysis in 11,502 participants aged 40 and above, from a well-defined commu...
Plant-Microbe Communication Enhances Auxin Biosynthesis by a Root-Associated Bacterium, Bacillus amyloliquefaciens SQR9.
Molecular Plant-Microbe Interactions 29(4):324 (2016)
Mechanisms by which beneficial rhizobacteria promote plant growth include tryptophan-dependent indole-3-acetic acid (IAA) synthesis. The abundance of tryptophan in the rhizosphere, however, may influence the level of benefit provided by IAA-producing rhizobacteria. This study examined the cucumb...
Coordinative Modulation of Chlorothricin Biosynthesis by Binding of the Glycosylated Intermediates and End Product to a Responsive Regulator ChlF1.
Journal of Biological Chemistry 291(10):5406 (2016)
Chlorothricin, isolated from Streptomyces antibioticus, is a parent member of spirotetronate family of antibiotics that have long been appreciated for their remarkable biological activities. ChlF1 plays bifunctional roles in chlorothricin biosynthesis by binding to its target genes (chlJ, chlF1,...
[CT and MRI manifestations of the axial area primary peripheral primitive neuroectodermal tumors].
Zhongguo gu shang = China journal of orthopaedi... 29(3):252 (2016)
To explore CT and MRI manifestations of the axial area peripheral primitive neuroectodermal tumors (pPNETs) in order to improve the knowledge of this disease.
The clinical data of 10 patients with pPNETs underwent pathologically confirmed were retrospectively analyzed from October 2008 to May 20...
Association between the change in body mass index from early adulthood to midlife and subsequent type 2 diabetes mellitus.
Obesity 24(3):703 (2016)
To clarify the quantitative relationship of body mass index (BMI) change from early adulthood to midlife with presence of type 2 diabetes mellitus (T2DM) after midlife.
This study included 120,666 middle-aged and elderly, whose retrospectively self-reported body weight at 20 and 40 years and mea...
Low pretreatment serum globulin may predict favorable prognosis for gastric cancer patients.
Tumor Biology 37(3):3905 (2016)
An elevated serum albumin (ALB) and albumin/globulin ratio (AGR) have been reported to be associated with a favorable prognosis for several types of cancer. However, little is known about prognostic significance of globulin (GLB) in gastric cancer patients. The purpose of this study was to evalu...
Association of Serum Fetuin-A Levels With the Risk of Albuminuria in Middle-Aged and Elderly Chinese.
Journal of Clinical Endocrinology & Metabolism 101(3):1235 (2016)
Fetuin-A is an important hepatokine associated with many cardiometabolic abnormities. The association between fetuin-A and albuminuria has not been investigated in a prospective cohort.
The objective of the study was to prospectively investigate whether serum fetuin-A levels were associated with...