1. S-7 : A new cytokine receptor activation paradigm: Activation of JAK2 by the growth hormone receptor

    Cytokine 70(1):22 (2014)

    The conformational changes required to transmit the GH binding signal from the extracellular domain of the GH receptor to its intracellular domain resulting in activation of JAK2 has been enigmatic. We have recently defined the first complete mechanistic model for JAK2 activation based...
  2. A new mechanism for growth hormone receptor activation of JAK2, and implications for related cytokine receptors.

    JAK-STAT 3:e29569 (2014) PMID 25101218 PMCID PMC4119067

    The growth hormone receptor was the first cytokine receptor to be cloned and crystallized, and provides a valuable exemplar for activation of its cognate kinase, JAK2. We review progress in understanding its activation mechanism, in particular the molecular movements made by this constitutively ...
  3. Differential response to sustained stimulation by hCG & LH on goat ovarian granulosa cells.

    Indian Journal of Medical Research 135:331 (2012) PMID 22561619 PMCID PMC3361869

    Chapekar established a model of ovarian tumourigenesis in mice by splenic transplantation of ovaries, resulting in sustained luteinizing hormone (LH) levels because of absence of feedback inhibition. There is increasing evidence of the differential response to LH or hCG under various experimenta...