N-methylation of a bactericidal compound as a resistance mechanism in Mycobacterium tuberculosis.
PNAS 113(31):E4523 (2016)
The rising incidence of antimicrobial resistance (AMR) makes it imperative to understand the underlying mechanisms. Mycobacterium tuberculosis (Mtb) is the single leading cause of death from a bacterial pathogen and estimated to be the leading cause of death from AMR. A pyrido-benzimidazole, 14,...
Novel Cephalosporins Selectively Active on Nonreplicating Mycobacterium tuberculosis.
Journal of medicinal and pharmaceutical chemistry 59(13):6027 (2016)
We report two series of novel cephalosporins that are bactericidal to Mycobacterium tuberculosis alone of the pathogens tested, which only kill M. tuberculosis when its replication is halted by conditions resembling those believed to pertain in the host, and whose bactericidal activity is not de...
Cdx-2 polymorphism in Vitamin D Receptor gene was associated with serum 25-hydroxyvitamin D levels, bone mineral density and fracture in middle-aged and elderly Chinese women.
Molecular and Cellular Endocrinology 427:155 (2016)
The aim of the current study was to examine the relationship between Cdx-2 polymorphism in the promoter region of the VDR gene and serum 25-hydroxyvitamin D (25(OH)D) levels, bone mineral density (BMD) and fracture in Chinese population. This was a cross-sectional study, which included 738 indiv...
Erratum to: A novel APOC2 gene mutation identified in a Chinese patient with severe hypertriglyceridemia and recurrent pancreatitis.
Lipids in Health and Disease 15(1):42 (2016)
A novel APOC2 gene mutation identified in a Chinese patient with severe hypertriglyceridemia and recurrent pancreatitis.
Lipids in Health and Disease 15(1):12 (2016)
The severe forms of hypertriglyceridemia are usually caused by genetic defects. In this study, we described a Chinese female with severe hypertriglyceridemia caused by a novel homozygous mutation in the APOC2 gene.
Lipid profiles of the pedigree were studied in detail. LPL and HL activity were a...
Three supplementary methods for analyzing cytotoxicity of Escherichia coli O157:H7.
Journal of Microbiological Methods 120:34 (2016)
Escherichia coli O157:H7 is an enterohemorrhagic E. coli (EHEC) strain and a major food-borne pathogen, causing severe disease in humans worldwide. Multiple sensitive, accurate, and quantitative methods are needed to provide a comprehensive analysis of cell damage caused by O157:H7. However, the...
Rapid, Semiquantitative Assay To Discriminate among Compounds with Activity against Replicating or Nonreplicating Mycobacterium tuberculosis.
Antimicrobial Agents and Chemotherapy 59(10):6521 (2015)
The search for drugs that can kill replicating and nonreplicating Mycobacterium tuberculosis faces practical bottlenecks. Measurement of CFU and discrimination of bacteriostatic from bactericidal activity are costly in compounds, supplies, labor, and time. Testing compounds against M. tuberculos...
Functional and numerical responses of Cyrtorhinus lividipennis to eggs of Nilaparvata lugens are not affected by genetically modified herbicide-tolerant rice
Journal of Integrative Agriculture 14(10):2019 (2015)
To safely and sustainably utilize genetic breeding techniques for crop production, greater understanding of the potential effects of genetically modified herbicide-tolerant (GMHT) crops on the ecological functions of predators is required. In the laboratory, we examined the functional ...
Competing in China: Introduction to the special section
Journal of Business Research 68(6) (2015)
This introduction is a guide to the reader through the papers in the special section on “Competing in China: Local Firms, Multinationals, and Alliances”. These papers develop useful insights for business scholars and practitioners, based on the analysis of problems and situations that ...
p53 inhibition provides a pivotal protective effect against ischemia-reperfusion injury in vitro via mTOR signaling.
Brain research 1605:31 (2015)
Tumor suppressor p53 has recently been reported to have numerous functions independent of tumorigenesis, including neuronal survival during ischemia. The mammalian target of rapamycin (mTOR) signaling pathway plays a central role in the regulation of metabolism, cell growth, development, and cel...
Heparin inhibits the inflammatory response induced by LPS and HMGB1 by blocking the binding of HMGB1 to the surface of macrophages.
Cytokine 72(1):36 (2015)
High mobility group box 1 protein (HMGB1), a nuclear non-histone DNA-binding protein, is secreted extracellularly during inflammation and is a late mediator of inflammatory responses. The pro-inflammatory activity of recombinant HMGB1 proteins is dependent upon the formation of complexes with ot...
Von Hippel-Lindau disease type 2 in a Chinese family with a VHL p.W88X truncation.
Endocrine 48(1):83 (2015)
Von Hippel-Lindau (VHL) disease is an autosomal dominant syndrome caused by germline mutations in the synonymous VHL gene encoding a tumor suppressor. Affected individuals are susceptible to various benign and malignant tumors. Based on the phenotypes, VHL disease is classified as type 1 and typ...
Identification of Rv3852 as an Agrimophol-Binding Protein in Mycobacterium tuberculosis.
PLoS ONE 10(5):e0126211 (2015)
Mycobacterial tuberculosis (Mtb) is able to preserve its intrabacterial pH (pHIB) near neutrality in the acidic phagosomes of immunologically activated macrophages and to cause lethal pathology in immunocompetent mice. In contrast, when its ability to maintain pHIB homeostasis is genetically com...
Argonaute 2 and nasopharyngeal carcinoma: a genetic association study and functional analysis.
BMC Cancer 15:862 (2015)
Argonaute 2 (AGO2), a central component of RNA-induced silencing complex, plays critical roles in cancer. We examined whether the single nucleotide polymorphisms (SNPs) of AGO2 were related to the risk of nasopharyngeal carcinoma (NPC).
Twenty-five tag SNPs within AGO2 were genotyped in Guangxi ...
Thyroid Function, Prevalent Coronary Heart Disease, and Severity of Coronary Atherosclerosis in Patients Undergoing Coronary Angiography.
International Journal of Endocrinology 2015:708272 (2015)
This study investigated if free T4 and TSH concentrations or thyroid function categories were associated with prevalent CHD and the severity of coronary atherosclerosis in a population undergoing coronary angiography. This was a cross-sectional study including 1799 patients who were consecutivel...
Gene polymorphism of IL-6 and MMP-3 decreases passive range of motion after rotator cuff repair.
International journal of clinical and experimen... 8(5):5709 (2015)
Post-operative stiffness is common after rotator cuff repair, given the difference in susceptibility and severity, the genetic factors may be involved. Interleukin 6 (IL-6) and Matrix metalloproteinases 3 (MMP-3) were previous found as key cytokines in the pathologies of adhesive capsulitis. The...
Iron porphyrin carbenes as catalytic intermediates: structures, Mössbauer and NMR spectroscopic properties, and bonding.
Angewandte Chemie. International edition in Eng... 53(29):7574 (2014)
Iron porphyrin carbenes (IPCs) are thought to be intermediates involved in the metabolism of various xenobiotics by cytochrome P450, as well as in chemical reactions catalyzed by metalloporphyrins and engineered P450s. While early work proposed IPCs to contain Fe(II), more recent work invokes a ...
A new mutation in the CSB gene in a Chinese patient with mild Cockayne syndrome.
Clinical Case Reports 2(2):33 (2014)
Cockayne syndrome (CS) is a rare autosomal recessive genetic disease characterized by growth failure and progressive neurological degeneration. Here we report a mild form of CS patient who was homozygous for the C526T transition resulting in a new nonsense mutation, which converts Arg176 to a st...
Daptomycin exerts rapid bactericidal activity against Bacillus anthracis without disrupting membrane integrity.
Acta Pharmacologica Sinica 35(2):211 (2014)
To examine whether the novel cyclic lipopeptide antibiotic daptomycin could be used to treat anthrax and to study the mechanisms underlying its bactericidal action against Bacillus anthracis.
Spore-forming B anthracis AP422 was tested. MIC values of antibiotics were determined. Cell membrane pot...
Platelets promote tumour metastasis via interaction between TLR4 and tumour cell-released high-mobility group box1 protein.
Nature Communications 5:5256 (2014)
Increasing evidence suggests that TLR4 expression by tumour cells promotes tumour progression, but it is unclear whether TLR4 is involved in metastasis. Here we show that TLR4 deficiency significantly diminishes experimental lung metastasis without affecting primary tumour growth. Bone marrow tr...