1. Loss of N-Cadherin Expression in Tumor Transplants Produced From As+3- and Cd+2-Transformed Human Urothelial (UROtsa) Cell Lines.

    PLoS ONE 11(5):e0156310 (2016) PMID 27224422 PMCID PMC4880289

    Epithelial to mesenchymal transition is a process in which a cell experiences a loss of epithelial cell characteristics and acquires a more mesenchymal cell phenotype. In cancer, epithelial to mesenchymal transition has been proposed to play an important role during specific stages of tumor prog...
  2. SPARC Expression Is Selectively Suppressed in Tumor Initiating Urospheres Isolated from As+3- and Cd+2-Transformed Human Urothelial Cells (UROtsa) Stably Transfected with SPARC.

    PLoS ONE 11(1):e0147362 (2016) PMID 26783756 PMCID PMC4718619

    This laboratory previously analyzed the expression of SPARC in the parental UROtsa cells, their arsenite (As(+3)) and cadmium (Cd(+2))-transformed cell lines, and tumor transplants generated from the transformed cells. It was demonstrated that SPARC expression was down-regulated to background le...
  3. Metallothionein isoform 3 expression in human skin, related cancers and human skin derived cell cultures.

    Toxicology Letters 232(1):141 (2015) PMID 25290577

    Human skin is a well known target site of inorganic arsenic with effects ranging from hyperkeratosis to dermal malignancies. The current study characterizes the expression of a protein known to bind inorganic, As(3+), metallothionein 3 (MT-3). Expression of this protein was assessed immunohistoc...
  4. Cadherin expression, vectorial active transport, and metallothionein isoform 3 mediated EMT/MET responses in cultured primary and immortalized human proximal tubule cells.

    PLoS ONE 10(3):e0120132 (2015) PMID 25803827 PMCID PMC4372585

    Cultures of human proximal tubule cells have been widely utilized to study the role of EMT in renal disease. The goal of this study was to define the role of growth media composition on classic EMT responses, define the expression of E- and N-cadherin, and define the functional epitope of MT-3 t...
  5. Health system reform in rural China: voices of healthworkers and service-users.

    Social Science & Medicine 117:134 (2014) PMID 25063969

    Like many other countries China is undergoing major health system reforms, with the aim of providing universal health coverage, and addressing problems of low efficiency and inequity. The first phase of the reforms has focused on strengthening primary care and improving health insurance coverage...
  6. Sociosexuality in mainland China.

    Archives of Sexual Behavior 43(3):621 (2014) PMID 23740470

    The construct of sociosexuality or sociosexual orientation describes the extent to which people will have casual, uncommitted sexual relationships. The Sociosexual Orientation Inventory (SOI) has been used to measure sociosexuality in many countries, but not in China. The aims of this study were...
  7. Long-term α1B-adrenergic receptor activation shortens lifespan, while α1A-adrenergic receptor stimulation prolongs lifespan in association with decreased cancer incidence.

    Age 36(4):9675 (2014) PMID 24994537 PMCID PMC4150908

    The α1-adrenergic receptor (α1AR) subtypes, α1AAR and α1BAR, have differential effects in the heart and central nervous system. Long-term stimulation of the α1AAR subtype prolongs lifespan and provides cardio- and neuro-protective effects. We examined the lifespan of constitutively active mutant...
  8. High sex ratio as a correlate of depression in Chinese men.

    Journal of Affective Disorders 144(1-2):79 (2013) PMID 22840624

    There is a large and increasing excess of men in China, especially in poor rural areas, with millions now unable to marry. The study aimed to determine whether these high sex ratios influence the prevalence of depression. The study was a cross-sectional survey, using a self-completion questionna...
  9. Increased neuron specific enolase expression by urothelial cells exposed to or malignantly transformed by exposure to Cd²⁺ or As³⁺.

    Toxicology Letters 212(1):66 (2012) PMID 22613180 PMCID PMC3390755

    Neuron specific enolase (ENO2, γ-enolase) is a biomarker used to help identify neuroendocrine differentiation in tumors. This laboratory has shown that ENO2 might be a biomarker for exposure to cadmium and arsenite. In this study these observations are extended to the urothelial cell, where envi...
  10. Son preference and sex-selective abortion in China: informing policy options.

    International Journal of Public Health 57(3):459 (2012) PMID 21681450

    There is growing evidence in China that son preference is on the decline, but the sex ratio at birth is still the highest in the world at around 120 male births to 100 females. The aim of the study was to explore attitudes towards gender preference among people of reproductive age, to determine ...
  11. ZIP8 expression in human proximal tubule cells, human urothelial cells transformed by Cd+2 and As+3 and in specimens of normal human urothelium and urothelial cancer.

    Cancer Cell International 12(1):16 (2012) PMID 22550998 PMCID PMC3390278

    ZIP8 functions endogenously as a Zn+2/HCO3- symporter that can also bring cadmium (Cd+2) into the cell. It has also been proposed that ZIP8 participates in Cd-induced testicular necrosis and renal disease. In this study real-time PCR, western analysis, immunostaining and fluorescent localization...
  12. Comparison of expression patterns of keratin 6, 7, 16, 17, and 19 within multiple independent isolates of As(+3)- and Cd (+2)-induced bladder cancer : keratin 6, 7, 16, 17, and 19 in bladder cancer.

    Cell Biology and Toxicology 27(6):381 (2011) PMID 21927821

    This laboratory has generated a series of seven cadmium (Cd(+2))- and six arsenite (As(+3))-transformed urothelial cancer cell lines by exposure of parental UROtsa cells to each agent under similar conditions of exposure. In this study, the seven Cd(+2)-transformed cell lines were characterized ...
  13. The very high sex ratio in rural China: impact on the psychosocial wellbeing of unmarried men.

    Social Science & Medicine 73(9):1422 (2011) PMID 21907478

    China has the highest male to female sex ratio at birth (SRB) in the world, with levels highest in poor rural areas. Rural-to-urban migration also occurs on a huge scale, but household registration regulations prevent rural-dwellers from settling permanently in cities. However, urban registratio...
  14. Arsenic, cadmium and neuron specific enolase (ENO2, γ-enolase) expression in breast cancer.

    Cancer Cell International 11(1):41 (2011) PMID 22098917 PMCID PMC3233504

    Neuron specific enolase (ENO2, γ-enolase) has been used as a biomarker to help identify neuroendocrine differentiation in breast cancer. The goal of the present study was to determine if ENO2 expression in the breast epithelial cell is influenced by the environmental pollutants, arsenite and cad...
  15. Kindlin-2 Expression in Arsenite- and Cadmium-transformed Bladder Cancer Cell Lines and in Archival Specimens of Human Bladder Cancer

    Urology 77(6):1507.e1 (2011) PMID 21624607 PMCID PMC3105253

    Objective To confirm a microarray study that suggested that Kindlin-2 might play a role in the development and progression of bladder cancer. There has been no previous examination of Kindlin-2 expression in human bladder cancer.
  16. Differences in the epigenetic regulation of MT-3 gene expression between parental and Cd+2 or As+3 transformed human urothelial cells.

    Cancer Cell International 11(1):2 (2011) PMID 21303554 PMCID PMC3041731

    Studies have shown that metallothionein 3 (MT-3) is not expressed in normal urothelium or in the UROtsa cell line, but is expressed in urothelial cancer and in tumors generated from the UROtsa cells that have been transformed by cadmium (Cd+2) or arsenite (As+3).The present study had two major g...
  17. Kindlin-2 Expression in Arsenite- and Cadmium-transformed Bladder Cancer Cell Lines and in Archival Specimens of Human Bladder Cancer

    Urology 77(6):1507.e1 (2011) PMID 21624607 PMCID PMC3105253

    Objective To confirm a microarray study that suggested that Kindlin-2 might play a role in the development and progression of bladder cancer. There has been no previous examination of Kindlin-2 expression in human bladder cancer.
  18. Kindlin-2 Expression in Arsenite- and Cadmium-transformed Bladder Cancer Cell Lines and in Archival Specimens of Human Bladder Cancer

    Urology 77(6):1507.e1 (2011) PMID 21624607 PMCID PMC3105253

    Objective To confirm a microarray study that suggested that Kindlin-2 might play a role in the development and progression of bladder cancer. There has been no previous examination of Kindlin-2 expression in human bladder cancer.
  19. Kindlin-2 Expression in Arsenite- and Cadmium-transformed Bladder Cancer Cell Lines and in Archival Specimens of Human Bladder Cancer

    Urology 77(6):1507.e1 (2011) PMID 21624607 PMCID PMC3105253

    Objective To confirm a microarray study that suggested that Kindlin-2 might play a role in the development and progression of bladder cancer. There has been no previous examination of Kindlin-2 expression in human bladder cancer.
  20. SPARC gene expression is repressed in human urothelial cells (UROtsa) exposed to or malignantly transformed by cadmium or arsenite.

    Toxicology Letters 199(2):166 (2010) PMID 20837119 PMCID PMC2956785

    SPARC belongs to a class of extracellular matrix-associated proteins that have counteradhesive properties. The ability of SPARC to modulate cell-cell and cell-matrix interactions provides a strong rationale for studies designed to determine its expression in cancer. The objective of this study w...