1. Identification of lamin B-regulated chromatin regions based on chromatin landscapes.

    Molecular Biology of the Cell 26(14):2685 (2015) PMID 25995381 PMCID PMC4501365

    Lamins, the major structural components of the nuclear lamina (NL) found beneath the nuclear envelope, are known to interact with most of the nuclear peripheral chromatin in metazoan cells. Although NL-chromatin associations correlate with a repressive chromatin state, the role of lamins in teth...
  2. Lamin-B in systemic inflammation, tissue homeostasis, and aging.

    Nucleus (Austin, Tex. : Print) 6(3):183 (2015) PMID 25875575

    Gradual loss of tissue function (or homeostasis) is a natural process of aging and is believed to cause many age-associated diseases. In human epidemiology studies, the low-grade and chronic systemic inflammation in elderly has been correlated with the development of aging related pathologies. A...
  3. Splicing function of mitotic regulators links R-loop-mediated DNA damage to tumor cell killing.

    Journal of Cell Biology 209(2):235 (2015) PMID 25918225 PMCID PMC4411280

    Although studies suggest that perturbing mitotic progression leads to DNA damage and p53 activation, which in turn lead to either cell apoptosis or senescence, it remains unclear how mitotic defects trigger p53 activation. We show that BuGZ and Bub3, which are two mitotic regulators localized in...
  4. Estrogen receptor α inhibitor activates the unfolded protein response, blocks protein synthesis, and induces tumor regression.

    PNAS 112(15):4737 (2015) PMID 25825714 PMCID PMC4403155

    Recurrent estrogen receptor α (ERα)-positive breast and ovarian cancers are often therapy resistant. Using screening and functional validation, we identified BHPI, a potent noncompetitive small molecule ERα biomodulator that selectively blocks proliferation of drug-resistant ERα-positive breast ...
  5. Gas1 is a receptor for sonic hedgehog to repel enteric axons.

    PNAS 112(1):E73 (2015) PMID 25535338 PMCID PMC4291612

    The myenteric plexus of the enteric nervous system controls the movement of smooth muscles in the gastrointestinal system. They extend their axons between two peripheral smooth muscle layers to form a tubular meshwork arborizing the gut wall. How a tubular axonal meshwork becomes established wit...
  6. Gas1 is a receptor for sonic hedgehog to repel enteric axons.

    PNAS 112(1):E73 (2015) PMID 25535338

    The myenteric plexus of the enteric nervous system controls the movement of smooth muscles in the gastrointestinal system. They extend their axons between two peripheral smooth muscle layers to form a tubular meshwork arborizing the gut wall. How a tubular axonal meshwork becomes established wit...
  7. Gas1 is a receptor for sonic hedgehog to repel enteric axons.

    PNAS 112(1):E73 (2015) PMID 25535338 PMCID PMC4291612

    The myenteric plexus of the enteric nervous system controls the movement of smooth muscles in the gastrointestinal system. They extend their axons between two peripheral smooth muscle layers to form a tubular meshwork arborizing the gut wall. How a tubular axonal meshwork becomes established wit...
  8. Gas1 is a receptor for sonic hedgehog to repel enteric axons.

    PNAS 112(1):E73 (2015) PMID 25535338 PMCID PMC4291612

    The myenteric plexus of the enteric nervous system controls the movement of smooth muscles in the gastrointestinal system. They extend their axons between two peripheral smooth muscle layers to form a tubular meshwork arborizing the gut wall. How a tubular axonal meshwork becomes established wit...
  9. Age-associated loss of lamin-B leads to systemic inflammation and gut hyperplasia.

    Cell 159(4):829 (2014) PMID 25417159 PMCID PMC4243052

    Aging of immune organs, termed as immunosenescence, is suspected to promote systemic inflammation and age-associated disease. The cause of immunosenescence and how it promotes disease, however, has remained unclear. We report that the Drosophila fat body, a major immune organ, undergoes immunose...
  10. Age-associated loss of lamin-B leads to systemic inflammation and gut hyperplasia.

    Cell 159(4):829 (2014) PMID 25417159 PMCID PMC4243052

    Aging of immune organs, termed as immunosenescence, is suspected to promote systemic inflammation and age-associated disease. The cause of immunosenescence and how it promotes disease, however, has remained unclear. We report that the Drosophila fat body, a major immune organ, undergoes immunose...
  11. Age-Associated Loss of Lamin-B Leads to Systemic Inflammation and Gut Hyperplasia

    Cell 159(4):829 (2014) PMID 25417159 PMCID PMC4243052

    Aging of immune organs, termed as immunosenescence, is suspected to promote systemic inflammation and age-associated disease. The cause of immunosenescence and how it promotes disease, however, has remained unclear. We report that the Drosophila fat body, a major immune organ, undergoe...
  12. SIRT1 mediates the effect of GLP-1 receptor agonist exenatide on ameliorating hepatic steatosis.

    Diabetes 63(11):3637 (2014) PMID 24947350

    GLP-1 and incretin mimetics, such as exenatide, have been shown to attenuate hepatocyte steatosis in vivo and in vitro, but the specific underlying mechanism is unclear. SIRT1, an NAD(+)-dependent protein deacetylase, has been considered as a crucial regulator in hepatic lipid homeostasis by acc...
  13. SIRT1 mediates the effect of GLP-1 receptor agonist exenatide on ameliorating hepatic steatosis.

    Diabetes 63(11):3637 (2014) PMID 24947350

    GLP-1 and incretin mimetics, such as exenatide, have been shown to attenuate hepatocyte steatosis in vivo and in vitro, but the specific underlying mechanism is unclear. SIRT1, an NAD(+)-dependent protein deacetylase, has been considered as a crucial regulator in hepatic lipid homeostasis by acc...
  14. SIRT1 mediates the effect of GLP-1 receptor agonist exenatide on ameliorating hepatic steatosis.

    Diabetes 63(11):3637 (2014) PMID 24947350

    GLP-1 and incretin mimetics, such as exenatide, have been shown to attenuate hepatocyte steatosis in vivo and in vitro, but the specific underlying mechanism is unclear. SIRT1, an NAD(+)-dependent protein deacetylase, has been considered as a crucial regulator in hepatic lipid homeostasis by acc...
  15. A movable microelectrode array for chronic basal ganglia single-unit electrocorticogram co-recording in freely behaving rats.

    Neurological Sciences 35(9):1429 (2014) PMID 24838541

    The basal ganglia-cortical circuits are important for information process to brain function. However, chronic recording of single-unit activities in the basal ganglia nucleus has not yet been well established. We present a movable bundled microwire array for chronic subthalamic nucleus (STN) sin...
  16. A movable microelectrode array for chronic basal ganglia single-unit electrocorticogram co-recording in freely behaving rats.

    Neurological Sciences 35(9):1429 (2014) PMID 24838541

    The basal ganglia-cortical circuits are important for information process to brain function. However, chronic recording of single-unit activities in the basal ganglia nucleus has not yet been well established. We present a movable bundled microwire array for chronic subthalamic nucleus (STN) sin...
  17. Proliferation and differentiation of mouse embryonic stem cells lacking all lamins.

    Cell Research 23(12):1420 (2013) PMID 23979018 PMCID PMC3847566

  18. Proliferation and differentiation of mouse embryonic stem cells lacking all lamins.

    Cell Research 23(12):1420 (2013) PMID 23979018 PMCID PMC3847566

  19. Proliferation and differentiation of mouse embryonic stem cells lacking all lamins.

    Cell Research 23(12):1420 (2013) PMID 23979018 PMCID PMC3847566

  20. Hybrid DNA virus in Chinese patients with seronegative hepatitis discovered by deep sequencing.

    PNAS 110(25):10264 (2013) PMID 23716702 PMCID PMC3690853

    Seronegative hepatitis--non-A, non-B, non-C, non-D, non-E hepatitis--is poorly characterized but strongly associated with serious complications. We collected 92 sera specimens from patients with non-A-E hepatitis in Chongqing, China between 1999 and 2007. Ten sera pools were screened by Solexa d...