1. Evolution of the Telomere-Associated Protein POT1a in Arabidopsis thaliana Is Characterized by Positive Selection to Reinforce Protein-Protein Interaction.

    Molecular Biology and Evolution 32(5):1329 (2015) PMID 25697340 PMCID PMC4408415

    Gene duplication is a major driving force in genome evolution. Here, we explore the nature and origin of the POT1 gene duplication in Arabidopsis thaliana. Protection of Telomeres (POT1) is a conserved multifunctional protein that modulates telomerase activity and its engagement with telomeres. ...
  2. Drosophila Sugar Receptors in Sweet Taste Perception, Olfaction, and Internal Nutrient Sensing

    Current Biology 25(5):621 (2015) PMID 25702577

    Identification of nutritious compounds is dependent on expression of specific taste receptors in appropriate taste-cell types [1]. In contrast to mammals, which rely on a single, broadly tuned heterodimeric sugar receptor [2], the Drosophila genome harbors a small subfamily of eight, c...
  3. Drosophila sugar receptors in sweet taste perception, olfaction, and internal nutrient sensing.

    Current Biology 25(5):621 (2015) PMID 25702577

    Identification of nutritious compounds is dependent on expression of specific taste receptors in appropriate taste-cell types [1]. In contrast to mammals, which rely on a single, broadly tuned heterodimeric sugar receptor [2], the Drosophila genome harbors a small subfamily of eight, closely rel...
  4. POT1a and components of CST engage telomerase and regulate its activity in Arabidopsis.

    PLoS Genetics 10(10):e1004738 (2014) PMID 25329641 PMCID PMC4199523

    Protection of Telomeres 1 (POT1) is a conserved nucleic acid binding protein implicated in both telomere replication and chromosome end protection. We previously showed that Arabidopsis thaliana POT1a associates with the TER1 telomerase RNP, and is required for telomere length maintenance in viv...
  5. POT1a and components of CST engage telomerase and regulate its activity in Arabidopsis.

    PLoS Genetics 10(10):e1004738 (2014) PMID 25329641 PMCID PMC4199523

    Protection of Telomeres 1 (POT1) is a conserved nucleic acid binding protein implicated in both telomere replication and chromosome end protection. We previously showed that Arabidopsis thaliana POT1a associates with the TER1 telomerase RNP, and is required for telomere length maintenance in viv...
  6. POT1a and components of CST engage telomerase and regulate its activity in Arabidopsis.

    PLoS Genetics 10(10):e1004738 (2014) PMID 25329641 PMCID PMC4199523

    Protection of Telomeres 1 (POT1) is a conserved nucleic acid binding protein implicated in both telomere replication and chromosome end protection. We previously showed that Arabidopsis thaliana POT1a associates with the TER1 telomerase RNP, and is required for telomere length maintenance in viv...
  7. MERISTEM DISORGANIZATION1 encodes TEN1, an essential telomere protein that modulates telomerase processivity in Arabidopsis.

    Plant Cell 25(4):1343 (2013) PMID 23572541 PMCID PMC3663272

    Telomeres protect chromosome ends from being recognized as DNA damage, and they facilitate the complete replication of linear chromosomes. CST [for CTC1(Cdc13)/STN1/TEN1] is a trimeric chromosome end binding complex implicated in both aspects of telomere function. Here, we characterize TEN1 in t...
  8. Aquimarina longa sp. nov., isolated from seawater, and emended description of Aquimarina muelleri.

    International Journal of Systematic and Evoluti... 63(Pt 4):1235 (2013) PMID 22771683

    A novel Gram-stain-negative, rod-shaped, non-flagellated, strictly aerobic strain with gliding motility, designated SW024(T), was isolated from surface seawater of the South Pacific Gyre (26° 29' S 137° 56' W) during the Integrated Ocean Drilling Program Expedition 329. Phylogenetic analyses bas...
  9. MERISTEM DISORGANIZATION1 encodes TEN1, an essential telomere protein that modulates telomerase processivity in Arabidopsis.

    Plant Cell 25(4):1343 (2013) PMID 23572541 PMCID PMC3663272

    Telomeres protect chromosome ends from being recognized as DNA damage, and they facilitate the complete replication of linear chromosomes. CST [for CTC1(Cdc13)/STN1/TEN1] is a trimeric chromosome end binding complex implicated in both aspects of telomere function. Here, we characterize TEN1 in t...
  10. Aquimarina longa sp. nov., isolated from seawater, and emended description of Aquimarina muelleri.

    International Journal of Systematic and Evoluti... 63(Pt 4):1235 (2013) PMID 22771683

    A novel Gram-stain-negative, rod-shaped, non-flagellated, strictly aerobic strain with gliding motility, designated SW024(T), was isolated from surface seawater of the South Pacific Gyre (26° 29' S 137° 56' W) during the Integrated Ocean Drilling Program Expedition 329. Phylogenetic analyses bas...
  11. A Fructose Receptor Functions as a Nutrient Sensor in theDrosophilaBrain

    Cell 151(5):1113 (2012) PMID 23178127 PMCID PMC3509419

    Internal nutrient sensors play important roles in feeding behavior, yet their molecular structure and mechanism of action are poorly understood. Using Ca2+ imaging and behavioral assays, we show that the gustatory receptor 43a (Gr43a) functions as a narrowly tuned fructose receptor in ...
  12. A Fructose Receptor Functions as a Nutrient Sensor in the Drosophila Brain

    Cell 151(5):1113 (2012)

    Internal nutrient sensors play important roles in feeding behavior, yet their molecular structure and mechanism of action are poorly understood. Using Ca2+ imaging and behavioral assays, we show that the gustatory receptor 43a (Gr43a) functions as a narrowly tuned fructose receptor in ...
  13. A fructose receptor functions as a nutrient sensor in the Drosophila brain.

    Cell 151(5):1113 (2012) PMID 23178127 PMCID PMC3509419

    Internal nutrient sensors play important roles in feeding behavior, yet their molecular structure and mechanism of action are poorly understood. Using Ca(2+) imaging and behavioral assays, we show that the gustatory receptor 43a (Gr43a) functions as a narrowly tuned fructose receptor in taste ne...
  14. ATR cooperates with CTC1 and STN1 to maintain telomeres and genome integrity in Arabidopsis.

    Molecular Biology of the Cell 23(8):1558 (2012) PMID 22357613 PMCID PMC3327312

    The CTC1/STN1/TEN1 (CST) complex is an essential constituent of plant and vertebrate telomeres. Here we show that CST and ATR (ataxia telangiectasia mutated [ATM] and Rad3-related) act synergistically to maintain telomere length and genome stability in Arabidopsis. Inactivation of ATR, but not A...
  15. ATR cooperates with CTC1 and STN1 to maintain telomeres and genome integrity in Arabidopsis.

    Molecular Biology of the Cell 23(8):1558 (2012) PMID 22357613 PMCID PMC3327312

    The CTC1/STN1/TEN1 (CST) complex is an essential constituent of plant and vertebrate telomeres. Here we show that CST and ATR (ataxia telangiectasia mutated [ATM] and Rad3-related) act synergistically to maintain telomere length and genome stability in Arabidopsis. Inactivation of ATR, but not A...
  16. Discovery of 2-oxo-1,2-dihydrobenzo[cd]indole-6-sulfonamide derivatives as new RORγ inhibitors using virtual screening, synthesis and biological evaluation

    European Journal of Medicinal Chemistry (2010)

    Retinoic acid-related orphan receptor γ (RORγ), a member of the nuclear hormone receptor superfamily, is a promising therapeutic target for treating Th17-mediated autoimmune diseases. We performed structure-based virtual screening targeting the RORγ ligand-binding domain. Among the tes...
  17. Discovery of 2-oxo-1,2-dihydrobenzo[cd]indole-6-sulfonamide derivatives as new RORγ inhibitors using virtual screening, synthesis and biological evaluation

    European Journal of Medicinal Chemistry (2010)

    Retinoic acid-related orphan receptor γ (RORγ), a member of the nuclear hormone receptor superfamily, is a promising therapeutic target for treating Th17-mediated autoimmune diseases. We performed structure-based virtual screening targeting the RORγ ligand-binding domain. Among the tes...
  18. Discovery of 2-oxo-1,2-dihydrobenzo[cd]indole-6-sulfonamide derivatives as new RORγ inhibitors using virtual screening, synthesis and biological evaluation

    European Journal of Medicinal Chemistry (2010)

    Retinoic acid-related orphan receptor γ (RORγ), a member of the nuclear hormone receptor superfamily, is a promising therapeutic target for treating Th17-mediated autoimmune diseases. We performed structure-based virtual screening targeting the RORγ ligand-binding domain. Among the tes...
  19. Discovery of 2-oxo-1,2-dihydrobenzo[cd]indole-6-sulfonamide derivatives as new RORγ inhibitors using virtual screening, synthesis and biological evaluation

    European Journal of Medicinal Chemistry (2010)

    Retinoic acid-related orphan receptor γ (RORγ), a member of the nuclear hormone receptor superfamily, is a promising therapeutic target for treating Th17-mediated autoimmune diseases. We performed structure-based virtual screening targeting the RORγ ligand-binding domain. Among the tes...
  20. POT1 proteins in green algae and land plants: DNA-binding properties and evidence of co-evolution with telomeric DNA.

    Nucleic Acids Research 37(22):7455 (2009) PMID 19783822 PMCID PMC2794166

    Telomeric DNA terminates with a single-stranded 3' G-overhang that in vertebrates and fission yeast is bound by POT1 (Protection Of Telomeres). However, no in vitro telomeric DNA binding is associated with Arabidopsis POT1 paralogs. To further investigate POT1-DNA interaction in plants, we clone...