1. A Synergistic Interaction between Chk1- and MK2 Inhibitors in KRAS-Mutant Cancer.

    Cell 162(1):146 (2015) PMID 26140595

    KRAS is one of the most frequently mutated oncogenes in human cancer. Despite substantial efforts, no clinically applicable strategy has yet been developed to effectively treat KRAS-mutant tumors. Here, we perform a cell-line-based screen and identify strong synergistic interactions between cell...
  2. Clinical applications of adaptive servoventilation devices: part 2.

    Chest 146(3):858 (2014) PMID 25180729

    Adaptive servoventilation (ASV) is an automated treatment modality used to treat many types of sleep-disordered breathing. Although default settings are available, clinician-specified settings determined in the sleep laboratory are preferred. Depending on the device, setting choices may include ...
  3. Clinical applications of adaptive servoventilation devices: part 2.

    Chest 146(3):858 (2014) PMID 25180729

    Adaptive servoventilation (ASV) is an automated treatment modality used to treat many types of sleep-disordered breathing. Although default settings are available, clinician-specified settings determined in the sleep laboratory are preferred. Depending on the device, setting choices may include ...
  4. Clinical applications of adaptive servoventilation devices: part 2.

    Chest 146(3):858 (2014) PMID 25180729

    Adaptive servoventilation (ASV) is an automated treatment modality used to treat many types of sleep-disordered breathing. Although default settings are available, clinician-specified settings determined in the sleep laboratory are preferred. Depending on the device, setting choices may include ...
  5. Anticyclic modulated ventilation versus continuous positive airway pressure in patients with coexisting obstructive sleep apnea and Cheyne-Stokes respiration: a randomized crossover trial.

    Sleep Medicine 15(8):874 (2014) PMID 24841107

    Although coexisting obstructive sleep apnea (OSA) and Cheyne-Stokes respiration (CSR) occur frequently in patients with heart diseases, optimal treatment remains unclear. Positive airway pressure (PAP) effectively treats OSA and adaptive servo-ventilation (ASV) has been shown to improve CSR. We ...
  6. Anticyclic modulated ventilation versus continuous positive airway pressure in patients with coexisting obstructive sleep apnea and Cheyne–Stokes respiration: a randomized crossover trial

    Sleep Medicine 15(8):874 (2014)

    Background Although coexisting obstructive sleep apnea (OSA) and Cheyne–Stokes respiration (CSR) occur frequently in patients with heart diseases, optimal treatment remains unclear. Positive airway pressure (PAP) effectively treats OSA and adaptive servo-ventilation (ASV) has...
  7. Positive airway pressure therapy with adaptive servoventilation: part 1: operational algorithms.

    Chest 146(2):514 (2014) PMID 25091757

    The beginning of the 21st century witnessed the advent of new positive airway pressure (PAP) technologies for the treatment of central and complex (mixtures of obstructive and central) sleep apnea syndromes. Adaptive servoventilation (ASV) devices applied noninvasively via mask that act to maint...
  8. Positive airway pressure therapy with adaptive servoventilation: part 1: operational algorithms.

    Chest 146(2):514 (2014) PMID 25091757

    The beginning of the 21st century witnessed the advent of new positive airway pressure (PAP) technologies for the treatment of central and complex (mixtures of obstructive and central) sleep apnea syndromes. Adaptive servoventilation (ASV) devices applied noninvasively via mask that act to maint...
  9. [Sleep disorders in asthma and chronic obstructive pulmonary disease (COPD)].

    Therapeutische Umschau 71(5):301 (2014) PMID 24794341

    Sleep disturbances (SD) are a frequent finding in patients with asthma and chronic obstructive pulmonary disease (COPD) and have a negative impact on quality of life and the clinical course of the disease. The causes of SD are multiple and include for example respiratory symptoms and comorbiditi...
  10. [Sleep disorders in asthma and chronic obstructive pulmonary disease (COPD)].

    Therapeutische Umschau 71(5):301 (2014) PMID 24794341

    Sleep disturbances (SD) are a frequent finding in patients with asthma and chronic obstructive pulmonary disease (COPD) and have a negative impact on quality of life and the clinical course of the disease. The causes of SD are multiple and include for example respiratory symptoms and comorbiditi...
  11. Adaptive Servoventilation in Central Sleep Apnea

    Sleep Medicine Clinics 9(1):69 (2014)

    Adaptive servoventilation (ASV) represents the most recent advancement in the treatment of Cheyne-Stokes respiration and other forms of central sleep apnea. ASV interferes with the pathophysiologic changes of hyperventilatory breathing disturbances, and has been proved to most efficien...
  12. Opioid-Induced Central Sleep Apnea:Mechanisms and Therapies

    Sleep Medicine Clinics 9(1):49 (2014)

    Patients on chronic opioids have significant central sleep apnea (CSA) and complex sleep apnea. The mechanism of opioid-induced CSA most probably has to do with suppression of inspiration generated by the pre-Botzinger complex. The best approach for treatment of opioid-induced CSA is a...
  13. Response.

    Chest 143(6):1834 (2013) PMID 23732602

  14. Response.

    Chest 143(6):1834 (2013) PMID 23732602

  15. A novel extracorporeal CO(2) removal system: results of a pilot study of hypercapnic respiratory failure in patients with COPD.

    Chest 143(3):678 (2013) PMID 23460154 PMCID PMC3590884

    Hypercapnic respiratory failure in patients with COPD frequently requires mechanical ventilatory support. Extracorporeal CO2 removal (ECCO2R) techniques have not been systematically evaluated in these patients. This is a pilot study of a novel ECCO2R device that utilizes a single venous catheter...
  16. Evaluation of a noninvasive algorithm for differentiation of obstructive and central hypopneas.

    Sleep 36(3):363 (2013) PMID 23450252 PMCID PMC3571737

    The clear discrimination of central and obstructive hypopneas is highly relevant to avoid misinterpretation and inappropriate treatment of complicated breathing patterns. Esophageal manometry is the accepted standard for the differentiation of the phenotypes of sleep apnea. However, it is limite...
  17. A novel extracorporeal CO(2) removal system: results of a pilot study of hypercapnic respiratory failure in patients with COPD.

    Chest 143(3):678 (2013) PMID 23460154 PMCID PMC3590884

    Hypercapnic respiratory failure in patients with COPD frequently requires mechanical ventilatory support. Extracorporeal CO2 removal (ECCO2R) techniques have not been systematically evaluated in these patients. This is a pilot study of a novel ECCO2R device that utilizes a single venous catheter...
  18. Evaluation of a noninvasive algorithm for differentiation of obstructive and central hypopneas.

    Sleep 36(3):363 (2013) PMID 23450252 PMCID PMC3571737

    The clear discrimination of central and obstructive hypopneas is highly relevant to avoid misinterpretation and inappropriate treatment of complicated breathing patterns. Esophageal manometry is the accepted standard for the differentiation of the phenotypes of sleep apnea. However, it is limite...
  19. Opioid-induced sleep apnea: is it a real problem?

    Journal of clinical sleep medicine : JCSM : off... 8(5):577 (2012) PMID 23066371 PMCID PMC3459205

  20. Opioid-induced sleep apnea: is it a real problem?

    Journal of clinical sleep medicine : JCSM : off... 8(5):577 (2012) PMID 23066371 PMCID PMC3459205