1. Bayesian inference for improved single molecule fluorescence tracking.

    Biophysical Journal 94(12):4932 (2008) PMID 18339757 PMCID PMC2397372

    Single molecule tracking is widely used to monitor the change in position of lipids and proteins in living cells. In many experiments in which molecules are tagged with a single or small number of fluorophores, the signal/noise ratio may be limiting, the number of molecules is not known, and flu...
  2. Automated analysis of the architecture of receptors, imaged by atomic force microscopy.

    Micron 39(2):101 (2008) PMID 17296302

    Fast neurotransmission involves the operation of ionotropic receptors, which are multi-subunit proteins that respond to activation by opening an integral ion channel. Examples of such channels include the GABA(A) receptor, the 5-HT(3) receptor and the P2X receptor for ATP. These receptors contai...
  3. Single-molecule level analysis of the subunit composition of the T cell receptor on live T cells.

    PNAS 104(45):17662 (2007) PMID 17971442 PMCID PMC2077052

    The T cell receptor (TCR) expressed on most T cells is a protein complex consisting of TCRalphabeta heterodimers that bind antigen and cluster of differentiation (CD) 3epsilondelta, epsilongamma, and zetazeta dimers that initiate signaling. A long-standing controversy concerns whether there is o...
  4. A sequential Monte Carlo EM approach to the transcription factor binding site identification problem.

    PMID 17387112

    A significant and stubbornly intractable problem in genome sequence analysis has been the de novo identification of transcription factor binding sites in promoter regions. Although theoretically pleasing, probabilistic methods have faced difficulties due to model mismatch and the nature of the b...
  5. Atomic force microscopy study of the structural effects induced by echinomycin binding to DNA.

    Journal of Molecular Biology 345(4):745 (2005) PMID 15588823

    Atomic force microscopy (AFM) has been used to examine the conformational effects of echinomycin, a DNA bis-intercalating antibiotic, on linear and circular DNA. Four different 398 bp DNA fragments were synthesized, comprising a combination of normal and/or modified bases including 2,6-diaminopu...
  6. Bayesian estimation of quantum optical phase by photon counting

    Signal Processing 84(8):1461 (2004)

    Photon count distributions at the outputs of a Mach–Zehnder interferometer are highly dependent on the phase difference between the two arms of the apparatus. Experimental results have shown that phase information can be inferred from the data even at low mean intensities of ≲10 photons. He...
  7. Kernel estimates for one- and two-dimensional ion channel dwell-time densities.

    Biophysical Journal 82(1 Pt 1):29 (2002) PMID 11751293 PMCID PMC1302446

    In this paper, we compare nonparametric kernel estimates with smoothed histograms as methods for displaying logarithmically transformed dwell-time distributions. Kernel density plots provide a simpler means for producing estimates of the probability density function (pdf) and they have the advan...
  8. List of Contributors

  9. 4 - Information theory

    This chapter discusses the concepts of information and the related quantity entropy. Mutual and self-information concepts are applied to various models for communications channels. In nature, it is found that self-contained systems change from more highly organized structures to less org...
  10. Using axial dimensions to determine the proportions of line drawings in computer graphics

    Computer-Aided Design 13(6):377 (1981)

    The axial dimensions in an engineering drawing can be used to determine line length so that the drawing will be to scale unless out of scale dimensions are explicitly used. In addition, over and under dimensioning can be detected. Therefore changes can be made to the dimensions and the draw...