1. New, recurrent, and prevalent mutations: Clinical and molecular characterization of 26 Chinese patients with 17alpha-hydroxylase/17,20-lyase deficiency

    The Journal of Steroid Biochemistry and Molecul... 150:11 (2015)

    • Twenty-five complete forms of 17OHD and one partial form were included in the study. • Three novel mutations were identified, the genotypes are well correlated w...
  2. Status of Cardiovascular Health in Chinese Adults

    Journal of the American College of Cardiology 65(10):1013 (2015)

    Background Cardiovascular disease has become the leading cause of death in China.
  3. Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.

    Human Molecular Genetics 24(6):1791 (2015) PMID 25429064 PMCID PMC4351379

    Human height is associated with risk of multiple diseases and is profoundly determined by an individual's genetic makeup and shows a high degree of ethnic heterogeneity. Large-scale genome-wide association (GWA) analyses of adult height in Europeans have identified nearly 180 genetic loci. A rec...
  4. Effects of prediabetes mellitus alone or plus hypertension on subsequent occurrence of cardiovascular disease and diabetes mellitus: longitudinal study.

    Hypertension 65(3):525 (2015) PMID 25624343

    Whether prediabetes mellitus alone or combined with other disorders means a higher risk for cardiovascular disease (CVD) is still controversial. This study aimed to investigate the association between prediabetes mellitus and CVD and diabetes mellitus and to explore whether prediabetes mellitus ...
  5. Elevated circulating microRNA-122 is associated with obesity and insulin resistance in young adults.

    European Journal of Endocrinology 172(3):291 (2015) PMID 25515554

    MicroRNAs (miRNAs) are involved in the regulation of adiposity, but functional studies have yielded inconclusive results. Examining the associations of circulating miRNAs levels with obesity and insulin sensitivity in humans may lead to improved insights. Serum samples collected from 112 obese a...
  6. Flotation behaviors of ilmenite, titanaugite, and forsterite using sodium oleate as the collector

    Minerals Engineering 72:1 (2015)

    Graphical abstract Schematic illustration of sodium oleate reacting with the different elements on the ilmenite, titanaugite, and forsterite surfaces in different pH solutions. [Display omitted]
  7. Flotation behaviors of ilmenite, titanaugite, and forsterite using sodium oleate as the collector

    Minerals Engineering 72:1 (2015)

    Graphical abstract Schematic illustration of sodium oleate reacting with the different elements on the ilmenite, titanaugite, and forsterite surfaces in different pH solutions. [Display omitted]
  8. Study on the efficacy and safety of Jinlida in patients with inadequately controlled type-2 diabetes and dyslipidemia under life style intervention (ENJOY LIFE Study) 2(ENJOY LIFE).

    Journal Of Diabetes 7(2):268 (2015) PMID 25395304

  9. Decreased miR-146 expression in peripheral blood mononuclear cells is correlated with ongoing islet autoimmunity in type 1 diabetes patients 1miR-146.

    Journal Of Diabetes 7(2):158 (2015) PMID 24796653

    Type 1 diabetes mellitus (T1D) is a common autoimmune disease mediated by autoimmune attack against pancreatic β-cells. It has been reported that dysregulation of microRNAs (miRNAs) may contribute to the pathogenesis of autoimmune diseases, including T1D. The aim of the present study was to iden...
  10. Different effects of two dipeptidyl peptidase-4 inhibitors and glimepiride on β-cell function in a newly designed two-step hyperglycemic clamp DPP-IVβ.

    Journal Of Diabetes 7(2):213 (2015) PMID 24889731

    Dipeptidyl peptidase (DPP)-4 inhibitors and sulfonylureas may have different effects on islet function. We designed a new two-step hyperglycemic clamp to further compare the effects of sitagliptin, saxagliptin, and glimepiride on β-cell function and the incretin effect. The present study was a f...
  11. Flotation behaviors of ilmenite, titanaugite, and forsterite using sodium oleate as the collector

    Minerals Engineering 72:1 (2015)

    Graphical abstract Schematic illustration of sodium oleate reacting with the different elements on the ilmenite, titanaugite, and forsterite surfaces in different pH solutions. [Display omitted]
  12. Structural insights into the interactions of xpt riboswitch with novel guanine analogues: a molecular dynamics simulation study.

    Journal of Biomolecular Structure and Dynamics 33(2):234 (2015) PMID 24404773

    Ligand recognition in purine riboswitches is a complex process requiring different levels of conformational changes. Recent efforts in the area of purine riboswitch research have focused on ligand analogue binding studies. In the case of the guanine xanthine phosphoribosyl transferase (xpt) ribo...
  13. Exome sequencing reveals mutant genes with low penetrance involved in MEN2A-associated tumorigenesis.

    Endocrine-Related Cancer 22(1):23 (2015) PMID 25404689

    Activating rearranged during transfection (RET) mutations function as the initiating causative mutation for multiple endocrine neoplasia type 2A (MEN2A). However, no conclusive findings regarding the non-RET genetic events have been reported. This is the first study, to our knowledge, examining ...
  14. Exome sequencing reveals mutant genes with low penetrance involved in MEN2A-associated tumorigenesis.

    Endocrine-Related Cancer 22(1):23 (2015) PMID 25404689

    Activating rearranged during transfection (RET) mutations function as the initiating causative mutation for multiple endocrine neoplasia type 2A (MEN2A). However, no conclusive findings regarding the non-RET genetic events have been reported. This is the first study, to our knowledge, examining ...
  15. Structural insights into the interactions of xpt riboswitch with novel guanine analogues: a molecular dynamics simulation study.

    Journal of Biomolecular Structure and Dynamics 33(2):234 (2015) PMID 24404773

    Ligand recognition in purine riboswitches is a complex process requiring different levels of conformational changes. Recent efforts in the area of purine riboswitch research have focused on ligand analogue binding studies. In the case of the guanine xanthine phosphoribosyl transferase (xpt) ribo...
  16. A novel magnetic 4A zeolite adsorbent synthesised from kaolinite type pyrite cinder (KTPC)

    Solid State Sciences 39:52 (2015)

    As a solid waste, kaolinite type pyrite cinder (KTPC) is a special pyrite cinder, its mineral components include metakaolin and magnetite, and the chemical compositions of these minerals include SiO2, Al2O3, FeO and Fe2O3. In this study, a novel magnetic 4A zeolite adsorbent was synthe...
  17. Conditional deletion of Men1 in the pancreatic β-cell leads to glucagon-expressing tumor development.

    Endocrinology 156(1):48 (2015) PMID 25343275

    The tumor suppressor menin is recognized as a key regulator of β-cell proliferation. To induce tumorigenesis within the pancreatic β-cells, floxed alleles of Men1 were selectively ablated using Cre-recombinase driven by the insulin promoter. Despite the β-cell specificity of the RipCre, glucagon...
  18. Conditional deletion of Men1 in the pancreatic β-cell leads to glucagon-expressing tumor development.

    Endocrinology 1(1):48 (2015) PMID 25343275

    The tumor suppressor menin is recognized as a key regulator of β-cell proliferation. To induce tumorigenesis within the pancreatic β-cells, floxed alleles of Men1 were selectively ablated using Cre-recombinase driven by the insulin promoter. Despite the β-cell specificity of the RipCre, glucagon...
  19. A novel magnetic 4A zeolite adsorbent synthesised from kaolinite type pyrite cinder (KTPC)

    Solid State Sciences 39:52 (2015)

    As a solid waste, kaolinite type pyrite cinder (KTPC) is a special pyrite cinder, its mineral components include metakaolin and magnetite, and the chemical compositions of these minerals include SiO2, Al2O3, FeO and Fe2O3. In this study, a novel magnetic 4A zeolite adsorbent was synthe...
  20. A novel magnetic 4A zeolite adsorbent synthesised from kaolinite type pyrite cinder (KTPC)

    Solid State Sciences 39:52 (2015)

    As a solid waste, kaolinite type pyrite cinder (KTPC) is a special pyrite cinder, its mineral components include metakaolin and magnetite, and the chemical compositions of these minerals include SiO2, Al2O3, FeO and Fe2O3. In this study, a novel magnetic 4A zeolite adsorbent was synthe...