Circulating Prolactin and Risk of Type 2 Diabetes: A Prospective Study.
American Journal of Epidemiology 184(4):295 (2016)
Prolactin plays an important role in maintaining a normal glucose homeostasis during pregnancy and beyond. Studies investigating the association between prolactin and type 2 diabetes beyond pregnancy are rare and none is prospective. We aimed to examine whether prolactin associates with type 2 d...
Liraglutide ameliorates non-alcoholic fatty liver disease by enhancing mitochondrial architecture and promoting autophagy through the SIRT1/SIRT3-FOXO3a pathway.
Hepatology Research 46(9):933 (2016)
Overwhelming oxidative stress is implicated as crucial in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Liraglutide, a well-established antidiabetes drug, was recently reported to ameliorate NAFLD with an elusive mechanism. We used a mouse model to examine whether liraglutide co...
Factors affecting parathyroid hormone levels in different types of primary aldosteronism.
Clinical Endocrinology 85(2):267 (2016)
Recent studies have found that mild secondary hyperparathyroidism might be another clinical feature of patients with primary aldosteronims (PA), but whether serum parathyroid hormone level (PTH) is correlated with subtypes of PA and what contributes to the elevated PTH level remains unclear.
Ethanol extracts of chickpeas alter the total lipid content and expression levels of genes related to fatty acid metabolism in mouse 3T3-L1 adipocytes.
International Journal of Molecular Medicine 38(2):574 (2016)
Desi-type chickpeas, which have long been used as a natural treatment for diabetes, have been reported to lower visceral adiposity, dyslipidemia and insulin resistance induced by a chronic high-fat diet in rats. In this study, in order to examine the effects of chickpeas of this type in an in vi...
HLA-A*33-DR3 and A*33-DR9 haplotypes enhance the risk of type 1 diabetes in Han Chinese.
Journal Of Diabetes Investigation 7(4):514 (2016)
To investigate the typing for human leukocyte antigen (HLA) class I in Chinese patients with type 1 diabetes as a complement screening for HLA class II.
A total of 212 type 1 diabetic patients and 200 healthy controls were enrolled. The genetic polymorphisms of HLA class I and II were examined w...
ERBB-2 overexpression as a risk factor for malignant phaeochromocytomas and paraganglinomas.
Clinical Endocrinology 84(6):822 (2016)
There are currently no good histological or molecular markers to differentiate benign from malignant phaeochromocytomas and paraganglinomas (PPGLs). Our previous cross-sectional study observed that ERBB-2 overexpression was associated with malignant PPGLs. This study aimed to evaluate the predic...
Diabetes and Risk of Arterial Stiffness: A Mendelian Randomization Analysis.
Diabetes 65(6):1731 (2016)
We aimed to explore the causal association between type 2 diabetes (T2D) and increased arterial stiffness. We performed a Mendelian randomization (MR) analysis in 11,385 participants from a well-defined community study in Shanghai during 2011-2013. We genotyped 34 T2D-associated common variants ...
Plasma glucose and hemoglobin A1c for the detection of diabetes in Chinese adults.
Journal Of Diabetes 8(3):378 (2016)
The aim of the present study was to evaluate the performance of plasma glucose (PG) and HbA1c for the detection of diabetes in the general population in China.
A cross-sectional analysis was conducted in a nationally representative sample of 98,658 Chinese adults aged ≥18 years. Fasting plasma g...
Associations of smoking and alcohol consumption with impaired β-cell function in Chinese men.
Journal Of Diabetes 8(3):434 (2016)
The aims of the present study were to examine the association of cigarette smoking and alcohol consumption with impaired β-cell function in Chinese men, particularly the interaction of smoking and alcohol consumption on impaired insulin secretion.
A population-based cross-sectional study was per...
Vildagliptin as add-on therapy to insulin improves glycemic control without increasing risk of hypoglycemia in Asian, predominantly Chinese, patients with type 2 diabetes mellitus.
Journal Of Diabetes 8(3):345 (2016)
The aim of the present study was to investigate the efficacy and safety of vildagliptin added onto insulin with or without metformin in an Asian, predominantly Chinese, population with type 2 diabetes mellitus (T2DM).
In this 24-week, multicenter, double-blind, placebo-controlled trial, patients...
Relationship between glycated albumin and glycated hemoglobin according to glucose tolerance status: A multicenter study.
Diabetes Research and Clinical Practice 115:17 (2016)
To determine the relationship between glycated albumin (GA) and glycated hemoglobin (HbA1c) and to explore the association of glycated albumin/glycated hemoglobin (GA/HbA1c) ratio with glucose indices in Chinese subjects with varying glucose tolerance status.
This hospital-based, cross-sectional...
Type 2 Diabetes, Diabetes Genetic Score and Risk of Decreased Renal Function and Albuminuria: A Mendelian Randomization Study.
EBioMedicine 6:162 (2016)
Type 2 diabetes (T2D) is a risk factor for dysregulation of glomerular filtration rate (GFR) and albuminuria. However, whether the association is causal remains unestablished.
We performed a Mendelian Randomization (MR) analysis in 11,502 participants aged 40 and above, from a well-defined commu...
Obesity and peripheral arterial disease: A Mendelian Randomization analysis.
Atherosclerosis 247:218 (2016)
Observational studies showed that obesity is a major risk factor for peripheral arterial disease (PAD). However, conventional epidemiology studies are vulnerable to residual bias from confounding factors. We aimed to explore the causality of obesity in development of PAD using Mendelian Randomiz...
[Minimally invasive bi-endoscopic treatment of deep submandibular gland calculu].
West China Journal of Stomatology 34(2):169 (2016)
A study was conducted to evaluate the clinical application of sialendoscopy combined with conven tional laparoscopy in a 30 degree angle in depth salivary calculus of submandibular glands.
A total of seventeen patients were presented with repeated swelling in the unilateral submandibular area fr...
Association between the change in body mass index from early adulthood to midlife and subsequent type 2 diabetes mellitus.
Obesity 24(3):703 (2016)
To clarify the quantitative relationship of body mass index (BMI) change from early adulthood to midlife with presence of type 2 diabetes mellitus (T2DM) after midlife.
This study included 120,666 middle-aged and elderly, whose retrospectively self-reported body weight at 20 and 40 years and mea...
Efficacy and safety of linagliptin in Asian patients with type 2 diabetes mellitus inadequately controlled by metformin: A multinational 24-week, randomized clinical trial.
Journal Of Diabetes 8(2):229 (2016)
Despite the increasing prevalence of type 2 diabetes mellitus (T2DM) in Asia, clinical trials for glucose-lowering therapies are often dominated by Caucasian and/or Western populations. The present Phase III randomized placebo-controlled double-blind, 24-week study evaluated the efficacy and saf...
Association of Serum Fetuin-A Levels With the Risk of Albuminuria in Middle-Aged and Elderly Chinese.
Journal of Clinical Endocrinology & Metabolism 101(3):1235 (2016)
Fetuin-A is an important hepatokine associated with many cardiometabolic abnormities. The association between fetuin-A and albuminuria has not been investigated in a prospective cohort.
The objective of the study was to prospectively investigate whether serum fetuin-A levels were associated with...
Cold inducible RNA binding protein upregulation in pituitary corticotroph adenoma induces corticotroph cell proliferation via Erk signaling pathway.
Oncotarget 7(8):9175 (2016)
Cushing's disease is caused by pituitary corticotroph adenoma, and the pathogenesis of it has remained obscure. Here, we showed that cold inducible RNA binding protein (CIRP) was markedly elevated in corticotroph tumors. Forced overexpression of CIRP in murine AtT20 pituitary corticotroph cell l...
Discrete associations of the GCKR variant with metabolic risk in a Chinese population: longitudinal change analysis.
Diabetologia 59(2):307 (2016)
Glucokinase regulatory protein gene (GCKR) variant rs780092 is a novel genetic variant associated with serum triacylglycerol (TG) identified in a genome-wide association study in East Asians. We aimed to investigate associations of rs780092 with incident type 2 diabetes and dyslipidaemia, and th...
Diabetes-related metabolic risk factors in internal migrant workers in China: a national surveillance study.
The lancet. Diabetes & endocrinology 4(2):125 (2016)
Little is known about the cardiometabolic health of internal migrant workers in China. We aimed to examine the prevalence of diabetes-related cardiometabolic risk factors in this large, but little-studied population.
We did this national surveillance study within the Chinese Center for Disease C...