1. Regulation of Gene Transcription by Voltage-gated L-type Calcium Channel, Cav1.3.

    Journal of Biological Chemistry 290(8):4663 (2015) PMID 25538241

    Cav1.3 L-type Ca(2+) channel is known to be highly expressed in neurons and neuroendocrine cells. However, we have previously demonstrated that the Cav1.3 channel is also expressed in atria and pacemaking cells in the heart. The significance of the tissue-specific expression of the channel is un...
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  2. Regulation of Gene Transcription by Voltage-gated L-type Calcium Channel, Cav1.3.

    Journal of Biological Chemistry 290(8):4663 (2015) PMID 25538241 PMCID PMC4335206

    Cav1.3 L-type Ca(2+) channel is known to be highly expressed in neurons and neuroendocrine cells. However, we have previously demonstrated that the Cav1.3 channel is also expressed in atria and pacemaking cells in the heart. The significance of the tissue-specific expression of the channel is un...
  3. Regulation of gene transcription by voltage-gated L-type calcium channel, Cav1.3.

    Journal of Biological Chemistry 290(8):4663 (2015) PMID 25538241 PMCID PMC4335206

    Cav1.3 L-type Ca(2+) channel is known to be highly expressed in neurons and neuroendocrine cells. However, we have previously demonstrated that the Cav1.3 channel is also expressed in atria and pacemaking cells in the heart. The significance of the tissue-specific expression of the channel is un...
  4. Critical roles of a small conductance Ca²⁺-activated K⁺ channel (SK3) in the repolarization process of atrial myocytes.

    Cardiovascular Research 101(2):317 (2014) PMID 24282291 PMCID PMC3896251

    Small conductance Ca(2+)-activated K(+) channels (K(Ca)2 or SK channels) have been reported in excitable cells, where they aid in integrating changes in intracellular Ca(2+) (Ca(i)²⁺) with membrane potentials. We have recently reported the functional expression of SK channels in human and mouse ...
  5. Critical roles of a small conductance Ca²⁺-activated K⁺ channel (SK3) in the repolarization process of atrial myocytes.

    Cardiovascular Research 101(2):317 (2014) PMID 24282291 PMCID PMC3896251

    Small conductance Ca(2+)-activated K(+) channels (K(Ca)2 or SK channels) have been reported in excitable cells, where they aid in integrating changes in intracellular Ca(2+) (Ca(i)²⁺) with membrane potentials. We have recently reported the functional expression of SK channels in human and mouse ...
  6. Critical roles of a small conductance Ca²⁺-activated K⁺ channel (SK3) in the repolarization process of atrial myocytes.

    Cardiovascular Research 101(2):317 (2014) PMID 24282291 PMCID PMC3896251

    Small conductance Ca(2+)-activated K(+) channels (K(Ca)2 or SK channels) have been reported in excitable cells, where they aid in integrating changes in intracellular Ca(2+) (Ca(i)²⁺) with membrane potentials. We have recently reported the functional expression of SK channels in human and mouse ...
  7. Critical roles of a small conductance Ca²⁺-activated K⁺ channel (SK3) in the repolarization process of atrial myocytes.

    Cardiovascular Research 101(2):317 (2014) PMID 24282291 PMCID PMC3896251

    Small conductance Ca(2+)-activated K(+) channels (K(Ca)2 or SK channels) have been reported in excitable cells, where they aid in integrating changes in intracellular Ca(2+) (Ca(i)²⁺) with membrane potentials. We have recently reported the functional expression of SK channels in human and mouse ...
  8. Critical roles of a small conductance Ca²⁺-activated K⁺ channel (SK3) in the repolarization process of atrial myocytes.

    Cardiovascular Research 101(2):317 (2014) PMID 24282291 PMCID PMC3896251

    Small conductance Ca(2+)-activated K(+) channels (K(Ca)2 or SK channels) have been reported in excitable cells, where they aid in integrating changes in intracellular Ca(2+) (Ca(i)²⁺) with membrane potentials. We have recently reported the functional expression of SK channels in human and mouse ...
  9. Critical Roles of SK3 Calcium-Activated Potassium Channels in the Repolarization of Atrial Myocytes

    Biophysical Journal 106(2):118a (2014)

  10. Critical Roles of SK3 Calcium-Activated Potassium Channels in the Repolarization of Atrial Myocytes

    Biophysical Journal 106(2):118a (2014)

  11. Adenylyl cyclase subtype-specific compartmentalization: differential regulation of L-type Ca2+ current in ventricular myocytes.

    Circulation Research 112(12):1567 (2013) PMID 23609114 PMCID PMC3751398

    Adenylyl cyclase (AC) represents one of the principal molecules in the β-adrenergic receptor signaling pathway, responsible for the conversion of ATP to the second messenger, cAMP. AC types 5 (ACV) and 6 (ACVI) are the 2 main isoforms in the heart. Although highly homologous in sequence, these 2...
  12. Adenylyl cyclase subtype-specific compartmentalization: differential regulation of L-type Ca2+ current in ventricular myocytes.

    Circulation Research 112(12):1567 (2013) PMID 23609114 PMCID PMC3751398

    Adenylyl cyclase (AC) represents one of the principal molecules in the β-adrenergic receptor signaling pathway, responsible for the conversion of ATP to the second messenger, cAMP. AC types 5 (ACV) and 6 (ACVI) are the 2 main isoforms in the heart. Although highly homologous in sequence, these 2...
  13. Triclosan impairs excitation-contraction coupling and Ca2+ dynamics in striated muscle.

    PNAS 109(35):14158 (2012) PMID 22891308 PMCID PMC3435154

    Triclosan (TCS), a high-production-volume chemical used as a bactericide in personal care products, is a priority pollutant of growing concern to human and environmental health. TCS is capable of altering the activity of type 1 ryanodine receptor (RyR1), but its potential to influence physiologi...
  14. Triclosan impairs excitation-contraction coupling and Ca2+ dynamics in striated muscle.

    PNAS 109(35):14158 (2012) PMID 22891308 PMCID PMC3435154

    Triclosan (TCS), a high-production-volume chemical used as a bactericide in personal care products, is a priority pollutant of growing concern to human and environmental health. TCS is capable of altering the activity of type 1 ryanodine receptor (RyR1), but its potential to influence physiologi...
  15. Triclosan impairs excitation-contraction coupling and Ca2+ dynamics in striated muscle.

    PNAS 109(35):14158 (2012) PMID 22891308 PMCID PMC3435154

    Triclosan (TCS), a high-production-volume chemical used as a bactericide in personal care products, is a priority pollutant of growing concern to human and environmental health. TCS is capable of altering the activity of type 1 ryanodine receptor (RyR1), but its potential to influence physiologi...
  16. MicroRNA profiling predicts a variance in the proliferative potential of cardiac progenitor cells derived from neonatal and adult murine hearts.

    Journal of Molecular and Cellular Cardiology 52(1):264 (2012) PMID 22062954 PMCID PMC3362795

    Cardiac progenitor cells (CPCs) are multipotent cells that may offer tremendous potentials for the regeneration of injured myocardium. To expand the limited number of CPCs for effective clinical regeneration of myocardium, it is important to understand their proliferative potentials. Single-cell...
  17. MicroRNA profiling predicts a variance in the proliferative potential of cardiac progenitor cells derived from neonatal and adult murine hearts

    Journal of Molecular and Cellular Cardiology 52(1):264 (2012)

    Cardiac progenitor cells (CPCs) are multipotent cells that may offer tremendous potentials for the regeneration of injured myocardium. To expand the limited number of CPCs for effective clinical regeneration of myocardium, it is important to understand their proliferative potentials. Single...
  18. MicroRNA profiling predicts a variance in the proliferative potential of cardiac progenitor cells derived from neonatal and adult murine hearts.

    Journal of Molecular and Cellular Cardiology 52(1):264 (2012) PMID 22062954 PMCID PMC3362795

    Cardiac progenitor cells (CPCs) are multipotent cells that may offer tremendous potentials for the regeneration of injured myocardium. To expand the limited number of CPCs for effective clinical regeneration of myocardium, it is important to understand their proliferative potentials. Single-cell...
  19. Phorbol ester and endothelin-1 alter functional expression of Na+/Ca2+ exchange, K+, and Ca2+ currents in cultured neonatal rat myocytes.

    American Journal of Physiology - Heart and Circ... 300(2):H617 (2011) PMID 21131481 PMCID PMC3044063

    Endothelin-1 (ET-1) and activation of protein kinase C (PKC) have been implicated in alterations of myocyte function in cardiac hypertrophy and heart failure. Changes in cellular Ca2+ handling and electrophysiological properties also occur in these states and may contribute to mechanical dysfunc...
  20. Phorbol ester and endothelin-1 alter functional expression of Na+/Ca2+ exchange, K+, and Ca2+ currents in cultured neonatal rat myocytes.

    American Journal of Physiology - Heart and Circ... 300(2):H617 (2011) PMID 21131481 PMCID PMC3044063

    Endothelin-1 (ET-1) and activation of protein kinase C (PKC) have been implicated in alterations of myocyte function in cardiac hypertrophy and heart failure. Changes in cellular Ca2+ handling and electrophysiological properties also occur in these states and may contribute to mechanical dysfunc...