1. The role of extracellular matrix in age-related conduction disorders: a forgotten player?

    Journal of Geriatric Cardiology 12(1):76 (2015) PMID 25678907 PMCID PMC4308461

    Cardiovascular aging is a physiological process gradually leading to structural degeneration and functional loss of all the cardiac and vascular components. Conduction system is also deeply influenced by the aging process with relevant reflexes in the clinical side. Age-related arrhythmias carry...
  2. A primer of statistical methods for correlating parameters and properties of electrospun poly(l-lactide) scaffolds for tissue engineering-PART 2: Regression.

    Journal of Biomedical Materials Research, Part A 103(1):103 (2015) PMID 24668730

    This two-articles series presents an in-depth discussion of electrospun poly-l-lactide scaffolds for tissue engineering by means of statistical methodologies that can be used, in general, to gain a quantitative and systematic insight about effects and interactions between a handful of key scaffo...
  3. The role of extracellular matrix in age-related conduction disorders: a forgotten player?

    Journal of Geriatric Cardiology 12(1):76 (2015) PMID 25678907

    Cardiovascular aging is a physiological process gradually leading to structural degeneration and functional loss of all the cardiac and vascular components. Conduction system is also deeply influenced by the aging process with relevant reflexes in the clinical side. Age-related arrhythmias carry...
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  4. A primer of statistical methods for correlating parameters and properties of electrospun poly(L-lactide) scaffolds for tissue engineering--PART 1: design of experiments.

    Journal of Biomedical Materials Research, Part A 103(1):91 (2015) PMID 24616399

    Tissue engineering scaffolds produced by electrospinning are of enormous interest, but still lack a true understanding about the fundamental connection between the outstanding functional properties, the architecture, the mechanical properties, and the process parameters. Fragmentary results from...
  5. Evaluation of the radiotherapy treatment planning in the presence of a magnetic valve tissue expander.

    PLoS ONE 10(2):e0117548 (2015) PMID 25679529

    The combination of radiotherapy treatments and breast reconstruction, using temporary tissue expanders, generates several concerns due to the presence of a magnetic valve inside the radiation field. The objective of this work is to evaluate a radiotherapy treatment planning for a patient using a...
  6. In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9.

    Nature Biotechnology 33(1):102 (2015) PMID 25326897

    Probing gene function in the mammalian brain can be greatly assisted with methods to manipulate the genome of neurons in vivo. The clustered, regularly interspaced, short palindromic repeats (CRISPR)-associated endonuclease (Cas)9 from Streptococcus pyogenes (SpCas9) can be used to edit single o...
  7. Evaluation of the radiotherapy treatment planning in the presence of a magnetic valve tissue expander.

    PLoS ONE 10(2):e0117548 (2015) PMID 25679529 PMCID PMC4334510

    The combination of radiotherapy treatments and breast reconstruction, using temporary tissue expanders, generates several concerns due to the presence of a magnetic valve inside the radiation field. The objective of this work is to evaluate a radiotherapy treatment planning for a patient using a...
  8. A primer of statistical methods for correlating parameters and properties of electrospun poly(l-lactide) scaffolds for tissue engineering-PART 1: Design of experiments.

    Journal of Biomedical Materials Research, Part A 103(1):91 (2015) PMID 24616399

    Tissue engineering scaffolds produced by electrospinning are of enormous interest, but still lack a true understanding about the fundamental connection between the outstanding functional properties, the architecture, the mechanical properties, and the process parameters. Fragmentary results from...
  9. Evaluation of the radiotherapy treatment planning in the presence of a magnetic valve tissue expander.

    PLoS ONE 10(2):e0117548 (2015) PMID 25679529 PMCID PMC4334510

    The combination of radiotherapy treatments and breast reconstruction, using temporary tissue expanders, generates several concerns due to the presence of a magnetic valve inside the radiation field. The objective of this work is to evaluate a radiotherapy treatment planning for a patient using a...
  10. In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9.

    Nature Biotechnology 33(1):102 (2015) PMID 25326897

    Probing gene function in the mammalian brain can be greatly assisted with methods to manipulate the genome of neurons in vivo. The clustered, regularly interspaced, short palindromic repeats (CRISPR)-associated endonuclease (Cas)9 from Streptococcus pyogenes (SpCas9) can be used to edit single o...
  11. A primer of statistical methods for correlating parameters and properties of electrospun poly(L-lactide) scaffolds for tissue engineering--PART 2: regression.

    Journal of Biomedical Materials Research, Part A 103(1):103 (2015) PMID 24668730

    This two-articles series presents an in-depth discussion of electrospun poly-L-lactide scaffolds for tissue engineering by means of statistical methodologies that can be used, in general, to gain a quantitative and systematic insight about effects and interactions between a handful of key scaffo...
  12. Activation of Toll-like Receptor-2 by Endogenous Matrix Metalloproteinase-2 Modulates Dendritic-Cell-Mediated Inflammatory Responses.

    Cell Reports 9(5):1856 (2014) PMID 25466255

    Matrix metalloproteinase-2 (MMP-2) is involved in several physiological mechanisms, including wound healing and tumor progression. We show that MMP-2 directly stimulates dendritic cells (DCs) to both upregulate OX40L on the cell surface and secrete inflammatory cytokines. The mechanism underlyin...
  13. Activation of Toll-like Receptor-2 by Endogenous Matrix Metalloproteinase-2 Modulates Dendritic-Cell-Mediated Inflammatory Responses.

    Cell Reports 9(5):1856 (2014) PMID 25466255

    Matrix metalloproteinase-2 (MMP-2) is involved in several physiological mechanisms, including wound healing and tumor progression. We show that MMP-2 directly stimulates dendritic cells (DCs) to both upregulate OX40L on the cell surface and secrete inflammatory cytokines. The mechanism underlyin...
  14. Activation of toll-like receptor-2 by endogenous matrix metalloproteinase-2 modulates dendritic-cell-mediated inflammatory responses.

    Cell Reports 9(5):1856 (2014) PMID 25466255 PMCID PMC4336179

    Matrix metalloproteinase-2 (MMP-2) is involved in several physiological mechanisms, including wound healing and tumor progression. We show that MMP-2 directly stimulates dendritic cells (DCs) to both upregulate OX40L on the cell surface and secrete inflammatory cytokines. The mechanism underlyin...
  15. Activation of Toll-like Receptor-2 by Endogenous Matrix Metalloproteinase-2 Modulates Dendritic-Cell-Mediated Inflammatory Responses

    Cell Reports 9(5):1856 (2014)

    Matrix metalloproteinase-2 (MMP-2) is involved in several physiological mechanisms, including wound healing and tumor progression. We show that MMP-2 directly stimulates dendritic cells (DCs) to both upregulate OX40L on the cell surface and secrete inflammatory cytokines. The mechanism...
  16. Activation of toll-like receptor-2 by endogenous matrix metalloproteinase-2 modulates dendritic-cell-mediated inflammatory responses.

    Cell Reports 9(5):1856 (2014) PMID 25466255 PMCID PMC4336179

    Matrix metalloproteinase-2 (MMP-2) is involved in several physiological mechanisms, including wound healing and tumor progression. We show that MMP-2 directly stimulates dendritic cells (DCs) to both upregulate OX40L on the cell surface and secrete inflammatory cytokines. The mechanism underlyin...
  17. Activation of toll-like receptor-2 by endogenous matrix metalloproteinase-2 modulates dendritic-cell-mediated inflammatory responses.

    Cell Reports 9(5):1856 (2014) PMID 25466255

    Matrix metalloproteinase-2 (MMP-2) is involved in several physiological mechanisms, including wound healing and tumor progression. We show that MMP-2 directly stimulates dendritic cells (DCs) to both upregulate OX40L on the cell surface and secrete inflammatory cytokines. The mechanism underlyin...
  18. Activation of toll-like receptor-2 by endogenous matrix metalloproteinase-2 modulates dendritic-cell-mediated inflammatory responses.

    Cell Reports 9(5):1856 (2014) PMID 25466255 PMCID PMC4336179

    Matrix metalloproteinase-2 (MMP-2) is involved in several physiological mechanisms, including wound healing and tumor progression. We show that MMP-2 directly stimulates dendritic cells (DCs) to both upregulate OX40L on the cell surface and secrete inflammatory cytokines. The mechanism underlyin...
  19. Deconstructing transcriptional heterogeneity in pluripotent stem cells.

    Nature 516(7529):56 (2014) PMID 25471879 PMCID PMC4256722

    Pluripotent stem cells (PSCs) are capable of dynamic interconversion between distinct substates; however, the regulatory circuits specifying these states and enabling transitions between them are not well understood. Here we set out to characterize transcriptional heterogeneity in mouse PSCs by ...
  20. Biological response of human mesenchymal stromal cells to titanium grade 4 implants coated with PCL/ZrO2 hybrid materials synthesized by sol-gel route: in vitro evaluation.

    Materials Science and Engineering: C 45:395 (2014) PMID 25491844

    The surface modification of implantable materials in order to improve their biological proprieties, including tissue tolerance and osseointegration ability, by means of functional coating deposition is a promising strategy to provide a firm fixation of the implants. In this study, organic/inorga...