Whole blood for hemostatic resuscitation of major bleeding.
Transfusion 56 Suppl 2:S190 (2016)
Recent combat experience reignited interest in transfusing whole blood (WB) for patients with life-threatening bleeding. US Army data indicate that WB transfusion is associated with improved or comparable survival compared to resuscitation with blood components. These data complement randomized ...
Survival after ultramassive transfusion: a review of 1360 cases.
Transfusion 56(3):558 (2016)
Information about patient survival after transfusion of multiple blood volumes is limited, and most reports have focused on trauma patients.
Retrospective study of blood use and survival at 11 hospitals in six nations between 2009 and 2013. Ultramassive transfusion (UMT) was defined as transfusi...
A study protocol for a randomised controlled trial evaluating clinical effects of platelet transfusion products: the Pathogen Reduction Evaluation and Predictive Analytical Rating Score (PREPAReS) trial.
BMJ Open 6(1):e010156 (2016)
Patients with chemotherapy-induced thrombocytopaenia frequently experience minor and sometimes severe bleeding complications. Unrestrictive availability of safe and effective blood products is presumed by treating physicians as well as patients. Pathogen reduction technology potentially offers t...
Immunomodulation Induced by Stem Cell Mobilization and Harvesting in Healthy Donors: Increased Systemic Osteopontin Levels after Treatment with Granulocyte Colony-Stimulating Factor.
International Journal of Molecular Sciences 17(7) (2016)
Peripheral blood stem cells from healthy donors mobilized by granulocyte colony-stimulating factor (G-CSF) and harvested by leukapheresis are commonly used for allogeneic stem cell transplantation. The frequency of severe graft versus host disease is similar for patients receiving peripheral blo...
The Role of Recent Admixture in Forming the Contemporary West Eurasian Genomic Landscape
Current Biology 25(21):2878 (2015)
The Role of Recent Admixture in Forming the Contemporary West Eurasian Genomic Landscape.
Current Biology 25(19):2518 (2015)
Over the past few years, studies of DNA isolated from human fossils and archaeological remains have generated considerable novel insight into the history of our species. Several landmark papers have described the genomes of ancient humans across West Eurasia, demonstrating the presence of large-...
Global diversity, population stratification, and selection of human copy-number variation.
Science 349(6253):aab3761 (2015)
In order to explore the diversity and selective signatures of duplication and deletion human copy-number variants (CNVs), we sequenced 236 individuals from 125 distinct human populations. We observed that duplications exhibit fundamentally different population genetic and selective signatures th...
Storage and handling of blood components – perspectives.
Transfusion and Apheresis Science 51(2):103 (2014)
The storage and handling conditions of cellular blood components and plasma are often rigorous, which is causing extensive discard of components that may be of acceptable quality as the rules for “out of optimal storage conditions” seem to be based more on tradition than scientific investigation...
Effects of the Sangvia blood collection system on patients undergoing elective hip surgery.
Transfusion and Apheresis Science 51(2):91 (2014)
We have conducted a randomized controlled study where 164 patients were randomized to receive autologous salvaged blood collected by Sangvia™ Blood Salvage System or allogeneic red cell concentrates if transfusion was indicated by clinical judgement. The study was powered to detect if transfusio...
Bacterial contamination of blood components: Norwegian strategies in identifying donors with higher risk of inducing septic transfusion reactions in recipients.
Transfusion and Apheresis Science 51(2):97 (2014)
Bacterial contamination of blood and its cellular components remains the most common microbiological cause of transfusion associated morbidity and mortality, even in developed countries. This yet unresolved complication is seen more often in platelet transfusions, as platelet concentrates are st...
Ancient human genomes suggest three ancestral populations for present-day Europeans.
Nature 513(7518):409 (2014)
We sequenced the genomes of a ∼7,000-year-old farmer from Germany and eight ∼8,000-year-old hunter-gatherers from Luxembourg and Sweden. We analysed these and other ancient genomes with 2,345 contemporary humans to show that most present-day Europeans derive from at least three highly differenti...
Prehospital use of plasma: the blood bankers' perspective.
Shock 41 Suppl 1:39 (2014)
At the 2013 Traumatic Hemostasis and Oxygenation Research Network's Remote Damage Control Resuscitation symposium, a panel of senior blood bankers with both civilian and military background was invited to discuss their willingness and ability to supply prehospital plasma for resuscitation of mas...
Refrigerated platelets for the treatment of acute bleeding: a review of the literature and reexamination of current standards.
Shock 41 Suppl 1:51 (2014)
This review is a synopsis of the decisions that shaped global policy on platelet (PLT) storage temperature and a focused appraisal of the literature on which those discussions were based. We hypothesize that choices were centered on optimization of preventive PLT transfusion strategies, possibly...
Whole blood: the future of traumatic hemorrhagic shock resuscitation.
Shock 41 Suppl 1:62 (2014)
Toward the end of World War I and during World War II, whole-blood transfusions were the primary agent in the treatment of military traumatic hemorrhage. However, after World War II, the fractionation of whole blood into its components became widely accepted and replaced whole-blood transfusion ...
Trauma hemostasis and oxygenation research position paper on remote damage control resuscitation: definitions, current practice, and knowledge gaps.
Shock 41 Suppl 1:3 (2014)
The Trauma Hemostasis and Oxygenation Research Network held its third annual Remote Damage Control Resuscitation Symposium in June 2013 in Bergen, Norway. The Trauma Hemostasis and Oxygenation Research Network is a multidisciplinary group of investigators with a common interest in improving outc...
Low titer group O whole blood in emergency situations.
Shock 41 Suppl 1:70 (2014)
In past and ongoing military conflicts, the use of whole blood (WB) as a resuscitative product to treat trauma-induced shock and coagulopathy has been widely accepted as an alternative when availability of a balanced component-based transfusion strategy is restricted or lacking. In previous mili...
Norwegian red cross – 80 years in service for blood donors
Transfusion and Apheresis Science 50(1):136 (2014)
The voluntary, non-remunerated blood donation organization is the important part of the International Red Cross movement. Historically the Red Cross Blood Program was established in Oslo with the main objectives to recruit new donors, support the blood banks with recruiting materials a...
Erythrocytapheresis compared with whole blood phlebotomy for the treatment of hereditary haemochromatosis.
Blood transfusion = Trasfusione del sangue 12 Suppl 1:s84 (2014)
Hereditary haemochromatosis may result in severe organ damage which can be prevented by therapy. We studied the possible advantages and disadvantages of erythrocytapheresis as compared with phlebotomy in patients with hereditary haemochromatosis.
In a prospective, randomised, open-label study, p...
Blood doping: the flip side of transfusion and transfusion alternatives.
Transfusion and Apheresis Science 49(1):90 (2013)
Blood doping in sports has been a hot topic of present. Longitudinal follow up of hematological parameters in different endurance sports, during the 1990s and early 2000s, has provided considerable suspicions about extensive blood manipulation, with performance enhancing effects. Recent doping r...
Stem cell mobilization and harvesting by leukapheresis alters systemic cytokine levels in patients with multiple myeloma.
Cytotherapy 15(7):850 (2013)
Stem cell mobilization and harvesting by peripheral blood leukapheresis in patients with myeloma can alter plasma levels of certain cytokines. In the present study, we investigated the effects of these interventions on a larger group of cytokines.
Plasma cytokine levels were determined in 15 pat...