1. Latent TGF-β binding protein-2 is essential for the development of ciliary zonule microfibrils.

    Human Molecular Genetics 23(21):5672 (2014) PMID 24908666 PMCID PMC4189902

    Latent TGF-β-binding protein-2 (LTBP-2) is an extracellular matrix protein associated with microfibrils. Homozygous mutations in LTBP2 have been found in humans with genetic eye diseases such as congenital glaucoma and microspherophakia, indicating a critical role of the protein in eye developme...
  2. Latent TGF-β binding protein-2 is essential for the development of ciliary zonule microfibrils.

    Human Molecular Genetics 23(21):5672 (2014) PMID 24908666 PMCID PMC4189902

    Latent TGF-β-binding protein-2 (LTBP-2) is an extracellular matrix protein associated with microfibrils. Homozygous mutations in LTBP2 have been found in humans with genetic eye diseases such as congenital glaucoma and microspherophakia, indicating a critical role of the protein in eye developme...
  3. Attenuation of fibroblast growth factor signaling by poly-N-acetyllactosamine type glycans

    FEBS Letters 587(19):3195 (2013)

    • We found that human sperm treated with endo-β-galactosidase enhanced motility. • Sperm-associated poly-N-acetyllactosamine type glycans are heavily fucosylated. ...
  4. Attenuation of fibroblast growth factor signaling by poly-N-acetyllactosamine type glycans.

    FEBS Letters 587(19):3195 (2013) PMID 23968720 PMCID PMC4029356

    Fibroblast growth factors (FGFs) and their receptors are expressed in a variety of mammalian tissues, playing a role in development and cell proliferation. While analyzing human sperm motility, we found that sperm treated with endo-β-galactosidase (EBG), which specifically hydrolyzes poly-N-acet...
  5. Latent TGF-β binding protein 4 promotes elastic fiber assembly by interacting with fibulin-5.

    PNAS 110(8):2852 (2013) PMID 23382201 PMCID PMC3581912

    Elastic fiber assembly requires deposition of elastin monomers onto microfibrils, the mechanism of which is incompletely understood. Here we show that latent TGF-β binding protein 4 (LTBP-4) potentiates formation of elastic fibers through interacting with fibulin-5, a tropoelastin-binding protei...
  6. Latent TGF-β binding protein 4 promotes elastic fiber assembly by interacting with fibulin-5.

    PNAS 110(8):2852 (2013) PMID 23382201 PMCID PMC3581912

    Elastic fiber assembly requires deposition of elastin monomers onto microfibrils, the mechanism of which is incompletely understood. Here we show that latent TGF-β binding protein 4 (LTBP-4) potentiates formation of elastic fibers through interacting with fibulin-5, a tropoelastin-binding protei...
  7. In vivo regulation of steroid hormones by the Chst10 sulfotransferase in mouse.

    Journal of Biological Chemistry 288(7):5007 (2013) PMID 23269668 PMCID PMC3576103

    Chst10 adds sulfate to glucuronic acid to form a carbohydrate antigen, HNK-1, in glycoproteins and glycolipids. To determine the role of Chst10 in vivo, we generated systemic Chst10-deficient mutant mice. Although Chst10(-/-) mice were born and grew to adulthood with no gross defects, they were ...
  8. In vivo regulation of steroid hormones by the Chst10 sulfotransferase in mouse.

    Journal of Biological Chemistry 288(7):5007 (2013) PMID 23269668 PMCID PMC3576103

    Chst10 adds sulfate to glucuronic acid to form a carbohydrate antigen, HNK-1, in glycoproteins and glycolipids. To determine the role of Chst10 in vivo, we generated systemic Chst10-deficient mutant mice. Although Chst10(-/-) mice were born and grew to adulthood with no gross defects, they were ...
  9. Identification of mono- and disulfated N-acetyl-lactosaminyl Oligosaccharide structures as epitopes specifically recognized by humanized monoclonal antibody HMOCC-1 raised against ovarian cancer.

    Journal of Biological Chemistry 287(9):6592 (2012) PMID 22194598 PMCID PMC3307324

    A humanized monoclonal antibody raised against human ovarian cancer RMG-I cells and designated as HMOCC-1 (Suzuki, N., Aoki, D., Tamada, Y., Susumu, N., Orikawa, K., Tsukazaki, K., Sakayori, M., Suzuki, A., Fukuchi, T., Mukai, M., Kojima-Aikawa, K., Ishida, I., and Nozawa, S. (2004) Gynecol. Onc...
  10. Identification of mono- and disulfated N-acetyl-lactosaminyl Oligosaccharide structures as epitopes specifically recognized by humanized monoclonal antibody HMOCC-1 raised against ovarian cancer.

    Journal of Biological Chemistry 287(9):6592 (2012) PMID 22194598 PMCID PMC3307324

    A humanized monoclonal antibody raised against human ovarian cancer RMG-I cells and designated as HMOCC-1 (Suzuki, N., Aoki, D., Tamada, Y., Susumu, N., Orikawa, K., Tsukazaki, K., Sakayori, M., Suzuki, A., Fukuchi, T., Mukai, M., Kojima-Aikawa, K., Ishida, I., and Nozawa, S. (2004) Gynecol. Onc...
  11. Targeted drug delivery to tumor vasculature by a carbohydrate mimetic peptide.

    PNAS 108(49):19587 (2011) PMID 22114188 PMCID PMC3241764

    Although numerous carbohydrates play significant roles in mammalian cells, carbohydrate-based drug discovery has not been explored due to the technical difficulty of chemically synthesizing complex carbohydrate structures. Previously, we identified a series of carbohydrate mimetic peptides and f...
  12. Targeted drug delivery to tumor vasculature by a carbohydrate mimetic peptide.

    PNAS 108(49):19587 (2011) PMID 22114188 PMCID PMC3241764

    Although numerous carbohydrates play significant roles in mammalian cells, carbohydrate-based drug discovery has not been explored due to the technical difficulty of chemically synthesizing complex carbohydrate structures. Previously, we identified a series of carbohydrate mimetic peptides and f...
  13. Electron tomography reveals multiple self-association of chondroitin sulphate/dermatan sulphate proteoglycans in Chst5-null mouse corneas.

    Journal of Structural Biology 174(3):536 (2011) PMID 21440637

    The spatial distribution of collagen fibrils in the corneal stroma is essential for corneal transparency and is primarily regulated by extrafibrillar proteoglycans, which are multi-functional polymers that interact with hybrid type I/V collagen fibrils. In order to understand more about proteogl...
  14. Electron tomography reveals multiple self-association of chondroitin sulphate/dermatan sulphate proteoglycans in Chst5-null mouse corneas.

    Journal of Structural Biology 174(3):536 (2011) PMID 21440637

    The spatial distribution of collagen fibrils in the corneal stroma is essential for corneal transparency and is primarily regulated by extrafibrillar proteoglycans, which are multi-functional polymers that interact with hybrid type I/V collagen fibrils. In order to understand more about proteogl...
  15. Trophinin-mediated cell adhesion induces apoptosis of human endometrial epithelial cells through PKC-δ.

    Cell Cycle 10(1):135 (2011) PMID 21191175 PMCID PMC3048080

    Trophinin is an intrinsic membrane protein expressed in trophectoderm cells of embryos and in uterine epithelial cells. Trophinin potentially mediates apical cell adhesion at human embryo implantation sites through trophinin-trophinin binding in these two cell types. Trophinin-mediated cell adhe...
  16. Electron tomography reveals multiple self-association of chondroitin sulphate/dermatan sulphate proteoglycans inChst5-null mouse corneas

    Journal of Structural Biology 174(3):536 (2011)

    The spatial distribution of collagen fibrils in the corneal stroma is essential for corneal transparency and is primarily regulated by extrafibrillar proteoglycans, which are multi-functional polymers that interact with hybrid type I/V collagen fibrils. In order to understand more about pro...
  17. Trophinin-mediated cell adhesion induces apoptosis of human endometrial epithelial cells through PKC-δ.

    Cell Cycle 10(1):135 (2011) PMID 21191175 PMCID PMC3048080

    Trophinin is an intrinsic membrane protein expressed in trophectoderm cells of embryos and in uterine epithelial cells. Trophinin potentially mediates apical cell adhesion at human embryo implantation sites through trophinin-trophinin binding in these two cell types. Trophinin-mediated cell adhe...
  18. Structural collagen alterations in macular corneal dystrophy occur mainly in the posterior stroma.

    Current Eye Research 35(7):580 (2010) PMID 20597644

    Collagen fibrils in the corneal stroma in macular corneal dystrophy, on average, are more closely spaced than in the normal cornea. This study was conducted to investigate if this occurs uniformly across the stroma or is more prevalent at certain stromal depths. Microbeam synchrotron X-ray fiber...
  19. Structural collagen alterations in macular corneal dystrophy occur mainly in the posterior stroma.

    Current Eye Research 35(7):580 (2010) PMID 20597644

    Collagen fibrils in the corneal stroma in macular corneal dystrophy, on average, are more closely spaced than in the normal cornea. This study was conducted to investigate if this occurs uniformly across the stroma or is more prevalent at certain stromal depths. Microbeam synchrotron X-ray fiber...
  20. Structural and biochemical aspects of keratan sulphate in the cornea.

    Experientia. Basel 67(6):891 (2010) PMID 20213925

    Keratan sulphate (KS) is the predominant glycosaminoglycan (GAG) in the cornea of the eye, where it exists in proteoglycan (PG) form. KS-PGs have long been thought to play a pivotal role in the establishment and maintenance of the array of regularly-spaced and uniformly- thin collagen fibrils wh...