1. Netrin 1 regulates blood-brain barrier function and neuroinflammation.

    Brain 138(Pt 6):1598 (2015) PMID 25903786

    Blood-brain barrier function is driven by the influence of astrocyte-secreted factors. During neuroinflammatory responses the blood-brain barrier is compromised resulting in central nervous system damage and exacerbated pathology. Here, we identified endothelial netrin 1 induction as a vascular ...
  2. Robo3: the road taken.

    Developmental Cell 32(1):3 (2015) PMID 25584792

    Although axon guidance mechanisms are well conserved across the animal kingdom, neuronal circuit complexity increases dramatically in evolution. Reporting recently in Neuron, Zelina et al. (2014) uncover mammalian-specific changes in Robo3 that result in a switch from repellent to attractive sig...
  3. Robo3: the road taken.

    Developmental Cell 32(1):3 (2015) PMID 25584792

    Although axon guidance mechanisms are well conserved across the animal kingdom, neuronal circuit complexity increases dramatically in evolution. Reporting recently in Neuron, Zelina et al. (2014) uncover mammalian-specific changes in Robo3 that result in a switch from repellent to attractive sig...
  4. Substrate-bound protein gradients to study haptotaxis.

    Frontiers in bioengineering and biotechnology 3:40 (2015) PMID 25870855 PMCID PMC4378366

    Cells navigate in response to inhomogeneous distributions of extracellular guidance cues. The cellular and molecular mechanisms underlying migration in response to gradients of chemical cues have been investigated for over a century. Following the introduction of micropipettes and more recently ...
  5. Humidified microcontact printing of proteins: universal patterning of proteins on both low and high energy surfaces.

    Langmuir 30(40):12002 (2014) PMID 25222734

    Microcontact printing (μCP) of proteins is widely used for biosensors and cell biology but is constrained to printing proteins adsorbed to a low free energy, hydrophobic surface to a high free energy, hydrophilic surface. This strongly limits μCP as harsh chemical treatments are required to form...
  6. Humidified microcontact printing of proteins: universal patterning of proteins on both low and high energy surfaces.

    Langmuir 30(40):12002 (2014) PMID 25222734

    Microcontact printing (μCP) of proteins is widely used for biosensors and cell biology but is constrained to printing proteins adsorbed to a low free energy, hydrophobic surface to a high free energy, hydrophilic surface. This strongly limits μCP as harsh chemical treatments are required to form...
  7. Early netrin-1 expression impairs central nervous system remyelination.

    Annals of Neurology 76(2):252 (2014) PMID 24942777

    Chronically demyelinated multiple sclerosis (MS) lesions are frequently characterized by scarce undifferentiated oligodendrocyte progenitor cells (OPCs), suggesting the exhaustion of a local OPC pool followed by failure of recruitment and differentiation. Stimulating prompt OPC recruitment follo...
  8. Early netrin-1 expression impairs central nervous system remyelination.

    Annals of Neurology 76(2):252 (2014) PMID 24942777

    Chronically demyelinated multiple sclerosis (MS) lesions are frequently characterized by scarce undifferentiated oligodendrocyte progenitor cells (OPCs), suggesting the exhaustion of a local OPC pool followed by failure of recruitment and differentiation. Stimulating prompt OPC recruitment follo...
  9. Role of p38MAPK in S1P receptor-mediated differentiation of human oligodendrocyte progenitors.

    Glia 62(8):1361 (2014) PMID 24810969

    FTY720 is a sphingosine 1-phosphate receptor (S1PR) modulator used as a daily therapy to reduce disease activity in the relapsing form of multiple sclerosis (MS). FTY720 readily accesses the CNS. Previous studies have shown that phosphorylated FTY720 (FTY720-p) enhances oligodendrocyte progenito...
  10. Role of p38MAPK in S1P receptor-mediated differentiation of human oligodendrocyte progenitors.

    Glia 62(8):1361 (2014) PMID 24810969

    FTY720 is a sphingosine 1-phosphate receptor (S1PR) modulator used as a daily therapy to reduce disease activity in the relapsing form of multiple sclerosis (MS). FTY720 readily accesses the CNS. Previous studies have shown that phosphorylated FTY720 (FTY720-p) enhances oligodendrocyte progenito...
  11. Role of p38MAPK in S1P receptor-mediated differentiation of human oligodendrocyte progenitors.

    Glia 62(8):1361 (2014) PMID 24810969

    FTY720 is a sphingosine 1-phosphate receptor (S1PR) modulator used as a daily therapy to reduce disease activity in the relapsing form of multiple sclerosis (MS). FTY720 readily accesses the CNS. Previous studies have shown that phosphorylated FTY720 (FTY720-p) enhances oligodendrocyte progenito...
  12. Early netrin-1 expression impairs central nervous system remyelination.

    Annals of Neurology 76(2):252 (2014) PMID 24942777

    Chronically demyelinated multiple sclerosis (MS) lesions are frequently characterized by scarce undifferentiated oligodendrocyte progenitor cells (OPCs), suggesting the exhaustion of a local OPC pool followed by failure of recruitment and differentiation. Stimulating prompt OPC recruitment follo...
  13. Progressive disorganization of paranodal junctions and compact myelin due to loss of DCC expression by oligodendrocytes.

    Journal of Neuroscience 34(29):9768 (2014) PMID 25031414

    Paranodal axoglial junctions are critical for maintaining the segregation of axonal domains along myelinated axons; however, the proteins required to organize and maintain this structure are not fully understood. Netrin-1 and its receptor Deleted in Colorectal Cancer (DCC) are proteins enriched ...
  14. Progressive disorganization of paranodal junctions and compact myelin due to loss of DCC expression by oligodendrocytes.

    Journal of Neuroscience 34(29):9768 (2014) PMID 25031414

    Paranodal axoglial junctions are critical for maintaining the segregation of axonal domains along myelinated axons; however, the proteins required to organize and maintain this structure are not fully understood. Netrin-1 and its receptor Deleted in Colorectal Cancer (DCC) are proteins enriched ...
  15. Netrin-1 controls sympathetic arterial innervation.

    Journal of Clinical Investigation 124(7):3230 (2014) PMID 24937433 PMCID PMC4071369

    Autonomic sympathetic nerves innervate peripheral resistance arteries, thereby regulating vascular tone and controlling blood supply to organs. Despite the fundamental importance of blood flow control, how sympathetic arterial innervation develops remains largely unknown. Here, we identified the...
  16. Netrin-1 controls sympathetic arterial innervation.

    Journal of Clinical Investigation 124(7):3230 (2014) PMID 24937433 PMCID PMC4071369

    Autonomic sympathetic nerves innervate peripheral resistance arteries, thereby regulating vascular tone and controlling blood supply to organs. Despite the fundamental importance of blood flow control, how sympathetic arterial innervation develops remains largely unknown. Here, we identified the...
  17. Heterogeneity of oligodendrocyte progenitor cells in adult human brain.

    Annals of clinical and translational neurology 1(4):272 (2014) PMID 25590039 PMCID PMC4292744

    Remyelination in multiple sclerosis has been attributed to the presence of oligodendrocyte progenitor cells (OPCs) in brain parenchyma. However, the precise identity of these progenitors is poorly defined. Here, we characterized populations of OPCs in the adult human brain and examined their mye...
  18. Heterogeneity of oligodendrocyte progenitor cells in adult human brain.

    Annals of clinical and translational neurology 1(4):272 (2014) PMID 25590039

    Remyelination in multiple sclerosis has been attributed to the presence of oligodendrocyte progenitor cells (OPCs) in brain parenchyma. However, the precise identity of these progenitors is poorly defined. Here, we characterized populations of OPCs in the adult human brain and examined their mye...
  19. Heterogeneity of oligodendrocyte progenitor cells in adult human brain.

    Annals of clinical and translational neurology 1(4):272 (2014) PMID 25590039 PMCID PMC4292744

    Remyelination in multiple sclerosis has been attributed to the presence of oligodendrocyte progenitor cells (OPCs) in brain parenchyma. However, the precise identity of these progenitors is poorly defined. Here, we characterized populations of OPCs in the adult human brain and examined their mye...
  20. Maintaining and modifying connections: roles for axon guidance cues in the mature nervous system.

    PMID 24317322 PMCID PMC3857654