1. Cell Division: A New Role for the Kinetochore in Central Spindle Assembly.

    Current Biology 25(13):R554 (2015) PMID 26126279

    The central spindle, which is formed between segregating chromosomes, is a critical structure for cell division. However, it was unclear how the central spindle is assembled at anaphase onset. A recent study reveals that a conserved kinetochore protein network plays an essential role in initiati...
  2. CENP-32 is required to maintain centrosomal dominance in bipolar spindle assembly.

    Molecular Biology of the Cell 26(7):1225 (2015) PMID 25657325 PMCID PMC4454171

    Centrosomes nucleate spindle formation, direct spindle pole positioning, and are important for proper chromosome segregation during mitosis in most animal cells. We previously reported that centromere protein 32 (CENP-32) is required for centrosome association with spindle poles during metaphase...
  3. Neocentromeres.

    Current Biology 24(19):R946 (2014) PMID 25291631

  4. Neocentromeres

    Current Biology 24(19):R946 (2014)

    Neocentromeres are formed at new positions on a chromosome, and offer unique opportunities to study the regulation of centromere formation.
  5. Neocentromeres.

    Current Biology 24(19):R946 (2014) PMID 25291631

  6. Neocentromeres.

    Current Biology 24(19):R946 (2014) PMID 25291631

  7. Neocentromeres.

    Current Biology 24(19):R946 (2014) PMID 25291631

    Neocentromeres are formed at new positions on a chromosome, and offer unique opportunities to study the regulation of centromere formation.
  8. The centromere: chromatin foundation for the kinetochore machinery.

    Developmental Cell 30(5):496 (2014) PMID 25203206 PMCID PMC4160344

    Since discovery of the centromere-specific histone H3 variant CENP-A, centromeres have come to be defined as chromatin structures that establish the assembly site for the complex kinetochore machinery. In most organisms, centromere activity is defined epigenetically, rather than by specific DNA ...
  9. The Centromere: Chromatin Foundation for the Kinetochore Machinery

    Developmental Cell 30(5):496 (2014)

    Since discovery of the centromere-specific histone H3 variant CENP-A, centromeres have come to be defined as chromatin structures that establish the assembly site for the complex kinetochore machinery. In most organisms, centromere activity is defined epigenetically, rather than by spe...
  10. The centromere: chromatin foundation for the kinetochore machinery.

    Developmental Cell 30(5):496 (2014) PMID 25203206 PMCID PMC4160344

    Since discovery of the centromere-specific histone H3 variant CENP-A, centromeres have come to be defined as chromatin structures that establish the assembly site for the complex kinetochore machinery. In most organisms, centromere activity is defined epigenetically, rather than by specific DNA ...
  11. The Centromere: Chromatin Foundation for the Kinetochore Machinery

    Developmental Cell 30(5):496 (2014) PMID 25203206 PMCID PMC4160344

    Since discovery of the centromere-specific histone H3 variant CENP-A, centromeres have come to be defined as chromatin structures that establish the assembly site for the complex kinetochore machinery. In most organisms, centromere activity is defined epigenetically, rather than by spe...
  12. The CENP-O complex requirement varies among different cell types.

    Chromosome Research 22(3):293 (2014) PMID 24481920 PMCID PMC4129241

    CENP-U (CENP-50) is a component of the CENP-O complex, which includes CENP-O, CENP-P, CENP-Q, CENP-R, and CENP-U and is constitutively localized at kinetochores throughout the cell cycle in vertebrates. Although CENP-U deficiency results in some mitotic defects in chicken DT40 cells, CENP-U-defi...
  13. The CENP-O complex requirement varies among different cell types.

    Chromosome Research 22(3):293 (2014) PMID 24481920 PMCID PMC4129241

    CENP-U (CENP-50) is a component of the CENP-O complex, which includes CENP-O, CENP-P, CENP-Q, CENP-R, and CENP-U and is constitutively localized at kinetochores throughout the cell cycle in vertebrates. Although CENP-U deficiency results in some mitotic defects in chicken DT40 cells, CENP-U-defi...
  14. Reorganization of damaged chromatin by the exchange of histone variant H2A.Z-2.

    International Journal of Radiation Oncology*Bio... 89(4):736 (2014) PMID 24969791

    The reorganization of damaged chromatin plays an important role in the regulation of the DNA damage response. A recent study revealed the presence of 2 vertebrate H2A.Z isoforms, H2A.Z-1 and H2A.Z-2. However, the roles of the vertebrate H2A.Z isoforms are still unclear. Thus, in this study we ex...
  15. Reorganization of Damaged Chromatin by the Exchange of Histone Variant H2A.Z-2

    International Journal of Radiation Oncology*Bio... 89(4):736 (2014)

    Purpose The reorganization of damaged chromatin plays an important role in the regulation of the DNA damage response. A recent study revealed the presence of 2 vertebrate H2A.Z isoforms, H2A.Z-1 and H2A.Z-2. However, the roles of the vertebrate H2A.Z isoforms are still unclea...
  16. Histone H4 Lys 20 Monomethylation of the CENP-A Nucleosome Is Essential for Kinetochore Assembly

    Developmental Cell 29(6):740 (2014) PMID 24960696 PMCID PMC4081567

    In vertebrate cells, centromeres are specified epigenetically through the deposition of the centromere-specific histone CENP-A. Following CENP-A deposition, additional proteins are assembled on centromeric chromatin. However, it remains unknown whether additional epigenetic features of...
  17. Histone H4 Lys 20 monomethylation of the CENP-A nucleosome is essential for kinetochore assembly.

    Developmental Cell 29(6):740 (2014) PMID 24960696 PMCID PMC4081567

    In vertebrate cells, centromeres are specified epigenetically through the deposition of the centromere-specific histone CENP-A. Following CENP-A deposition, additional proteins are assembled on centromeric chromatin. However, it remains unknown whether additional epigenetic features of centromer...
  18. Histone H4 Lys 20 monomethylation of the CENP-A nucleosome is essential for kinetochore assembly.

    Developmental Cell 29(6):740 (2014) PMID 24960696 PMCID PMC4081567

    In vertebrate cells, centromeres are specified epigenetically through the deposition of the centromere-specific histone CENP-A. Following CENP-A deposition, additional proteins are assembled on centromeric chromatin. However, it remains unknown whether additional epigenetic features of centromer...
  19. The histone-fold complex MHF is remodeled by FANCM to recognize branched DNA and protect genome stability.

    Cell Research 24(5):560 (2014) PMID 24699063 PMCID PMC4011343

    Histone-fold proteins typically assemble in multiprotein complexes to bind duplex DNA. However, one histone-fold complex, MHF, associates with Fanconi anemia (FA) protein FANCM to form a branched DNA remodeling complex that senses and repairs stalled replication forks and activates FA DNA damage...
  20. The histone-fold complex MHF is remodeled by FANCM to recognize branched DNA and protect genome stability.

    Cell Research 24(5):560 (2014) PMID 24699063 PMCID PMC4011343

    Histone-fold proteins typically assemble in multiprotein complexes to bind duplex DNA. However, one histone-fold complex, MHF, associates with Fanconi anemia (FA) protein FANCM to form a branched DNA remodeling complex that senses and repairs stalled replication forks and activates FA DNA damage...