1. Macitentan reverses early obstructive pulmonary vasculopathy in rats: early intervention in overcoming the survivin-mediated resistance to apoptosis.

    American Journal of Physiology - Lung Cellular ... 308(6):L523 (2015) PMID 25539851

    It remains unknown whether current disease-targeting therapy can histologically reverse obstructive pulmonary vasculopathy and how the timing of the therapy influences the antiremodeling effects of the compound. We test the hypothesis that a novel endothelin receptor antagonist macitentan revers...
  2. Potential contribution of phenotypically modulated smooth muscle cells and related inflammation in the development of experimental obstructive pulmonary vasculopathy in rats.

    PLoS ONE 10(2):e0118655 (2015) PMID 25714834 PMCID PMC4340876

    We tested the hypothesis that phenotypically modulated smooth muscle cells (SMCs) and related inflammation are associated with the progression of experimental occlusive pulmonary vascular disease (PVD). Occlusive PVD was induced by combined exposure to a vascular endothelial growth factor recept...
  3. Potential contribution of phenotypically modulated smooth muscle cells and related inflammation in the development of experimental obstructive pulmonary vasculopathy in rats.

    PLoS ONE 10(2):e0118655 (2015) PMID 25714834 PMCID PMC4340876

    We tested the hypothesis that phenotypically modulated smooth muscle cells (SMCs) and related inflammation are associated with the progression of experimental occlusive pulmonary vascular disease (PVD). Occlusive PVD was induced by combined exposure to a vascular endothelial growth factor recept...
  4. Lack of CD4⁺CD25⁺FOXP3⁺ regulatory T cells is associated with resistance to intravenous immunoglobulin therapy in patients with Kawasaki disease.

    European Journal of Pediatrics 172(6):833 (2013) PMID 23340699

    The aim of this study was to investigate changes in CD4(+)CD25(+)FOXP3(+) regulatory T cells (Tregs) throughout the clinical course of Kawasaki disease (KD) and correlations with response to intravenous immunoglobulin (IVIg) therapy. Participants comprised 18 patients who fulfilled the diagnosti...
  5. The diameter of the inferior vena cava provides a noninvasive way of calculating central venous pressure in neonates.

    Acta Paediatrica 102(6):e241 (2013) PMID 23586684

    To explore a less invasive way of assessing preload in neonates than fitting catheters to measure central venous pressure (CVP). This study evaluated the relationship between inferior vena cava (IVC) measurements and gestational age (GA) or body weight (BW) in term and premature infants and the ...
  6. The diameter of the inferior vena cava provides a noninvasive way of calculating central venous pressure in neonates.

    Acta Paediatrica 102(6):e241 (2013) PMID 23586684

    To explore a less invasive way of assessing preload in neonates than fitting catheters to measure central venous pressure (CVP). This study evaluated the relationship between inferior vena cava (IVC) measurements and gestational age (GA) or body weight (BW) in term and premature infants and the ...
  7. Lack of CD4⁺CD25⁺FOXP3⁺ regulatory T cells is associated with resistance to intravenous immunoglobulin therapy in patients with Kawasaki disease.

    European Journal of Pediatrics 172(6):833 (2013) PMID 23340699

    The aim of this study was to investigate changes in CD4(+)CD25(+)FOXP3(+) regulatory T cells (Tregs) throughout the clinical course of Kawasaki disease (KD) and correlations with response to intravenous immunoglobulin (IVIg) therapy. Participants comprised 18 patients who fulfilled the diagnosti...
  8. Efficacy of immunoglobulin plus prednisolone for prevention of coronary artery abnormalities in severe Kawasaki disease (RAISE study): a randomised, open-label, blinded-endpoints trial.

    The Lancet 379(9826):1613 (2012) PMID 22405251

    Evidence indicates that corticosteroid therapy might be beneficial for the primary treatment of severe Kawasaki disease. We assessed whether addition of prednisolone to intravenous immunoglobulin with aspirin would reduce the incidence of coronary artery abnormalities in patients with severe Kaw...
  9. Efficacy of immunoglobulin plus prednisolone for prevention of coronary artery abnormalities in severe Kawasaki disease (RAISE study): a randomised, open-label, blinded-endpoints trial

    The Lancet 379(9826):1613 (2012)

    Background Evidence indicates that corticosteroid therapy might be beneficial for the primary treatment of severe Kawasaki disease. We assessed whether addition of prednisolone to intravenous immunoglobulin with aspirin would reduce the incidence of coronary artery abnormalit...
  10. Efficacy of immunoglobulin plus prednisolone for prevention of coronary artery abnormalities in severe Kawasaki disease (RAISE study): a randomised, open-label, blinded-endpoints trial.

    The Lancet 379(9826):1613 (2012) PMID 22405251

    Evidence indicates that corticosteroid therapy might be beneficial for the primary treatment of severe Kawasaki disease. We assessed whether addition of prednisolone to intravenous immunoglobulin with aspirin would reduce the incidence of coronary artery abnormalities in patients with severe Kaw...
  11. Estrogen-like activity and dual roles in cell signaling of anAgaricus blazeiMurrill mycelia-dikaryon extract

    Microbiological Research 167(4):231 (2012) PMID 22015258

    Agaricus blazei (A. blazei) Murrill mycelia-dikaryon has attracted the attention of scientists and clinicians worldwide owing to its potential for the treatment of cancer. However, little is known about its effect on other pathologies. This study sought to extend the potential medical ...
  12. Estrogen-like activity and dual roles in cell signaling of an Agaricus blazei Murrill mycelia-dikaryon extract.

    Microbiological Research 167(4):231 (2012) PMID 22015258

    Agaricus blazei (A. blazei) Murrill mycelia-dikaryon has attracted the attention of scientists and clinicians worldwide owing to its potential for the treatment of cancer. However, little is known about its effect on other pathologies. This study sought to extend the potential medical usefulness...
  13. Estrogen-like activity and dual roles in cell signaling of anAgaricus blazeiMurrill mycelia-dikaryon extract

    Microbiological Research 167(4):231 (2012)

    Agaricus blazei (A. blazei) Murrill mycelia-dikaryon has attracted the attention of scientists and clinicians worldwide owing to its potential for the treatment of cancer. However, little is known about its effect on other pathologies. This study sought to extend the potential medical ...
  14. Estrogen-like activity and dual roles in cell signaling of an Agaricus blazei Murrill mycelia-dikaryon extract.

    Microbiological Research 167(4):231 (2012) PMID 22015258

    Agaricus blazei (A. blazei) Murrill mycelia-dikaryon has attracted the attention of scientists and clinicians worldwide owing to its potential for the treatment of cancer. However, little is known about its effect on other pathologies. This study sought to extend the potential medical usefulness...
  15. Estrogen-like activity and dual roles in cell signaling of an Agaricus blazei Murrill mycelia-dikaryon extract.

    Microbiological Research 167(4):231 (2012) PMID 22015258

    Agaricus blazei (A. blazei) Murrill mycelia-dikaryon has attracted the attention of scientists and clinicians worldwide owing to its potential for the treatment of cancer. However, little is known about its effect on other pathologies. This study sought to extend the potential medical usefulness...
  16. Coronary arterial ectasia in a 2-year-old boy showing two symptoms of Kawasaki disease without manifesting fever.

    Rheumatology International 32(4):1101 (2012) PMID 21431942

  17. Coronary arterial ectasia in a 2-year-old boy showing two symptoms of Kawasaki disease without manifesting fever.

    Rheumatology International 32(4):1101 (2012) PMID 21431942

  18. Captive rearing and release of Bar-headed Geese (Anser indicus) in China: a possible HPAI H5N1 virus infection route to wild birds.

    Journal of Wildlife Diseases 46(4):1340 (2010) PMID 20966292

  19. Captive rearing and release of Bar-headed Geese (Anser indicus) in China: a possible HPAI H5N1 virus infection route to wild birds.

    Journal of Wildlife Diseases 46(4):1340 (2010) PMID 20966292

  20. The autoregulation of nodulation mechanism is related to leaf development.

    Plant and Cell Physiology 49(1):121 (2008) PMID 18029379

    To understand the autoregulation of nodulation (AON) system, in which leguminous plants control the nodule number, we examined the details of the characteristics of hypernodulation soybean mutants NOD1-3 and NOD3-7. A microscopic study showed that NOD1-3 and NOD3-7 produced small-size leaves due...