1. Success Factors of Laparoscopic Nerve-sparing Radical Hysterectomy for Preserving Bladder Function in Patients with Cervical Cancer: A Protocol-Based Prospective Cohort Study.

    Annals of Surgical Oncology 22(6):1987 (2015) PMID 25465377

    Success factors of laparoscopic nerve-sparing radical hysterectomy (LNRH) to preserve bladder function are little known despite its widespread use. Thus, we conducted a protocol-based prospective cohort study to evaluate clinicopathologic factors for preserving autonomic nerves and its impact on...
  2. Structural Insights into the Dynamic Process of β2-Adrenergic Receptor Signaling.

    Cell 161(5):1101 (2015) PMID 25981665 PMCID PMC4441853

    G-protein-coupled receptors (GPCRs) transduce signals from the extracellular environment to intracellular proteins. To gain structural insight into the regulation of receptor cytoplasmic conformations by extracellular ligands during signaling, we examine the structural dynamics of the cytoplasmi...
  3. Safety of fertility-sparing surgery in primary mucinous carcinoma of the ovary.

    Cancer Research and Treatment 47(2):290 (2015) PMID 25287480 PMCID PMC4398117

    The aim of this study is to evaluate the safety of fertility-sparing surgery as the treatment for patients with primary mucinous epithelial ovarian cancer. A retrospective study of patients with mucinous ovarian cancer between 1991 and 2010 was performed. The demographics and survival outcomes w...
  4. Design and synthesis of novel 2-(indol-5-yl)thiazole derivatives as xanthine oxidase inhibitors.

    Bioorganic & Medicinal Chemistry Letters 25(6):1254 (2015) PMID 25704891

    Xanthine oxidase (XO) inhibitors have been widely used for the treatment of gout. Indole rings are frequently used as active scaffold in designing inhibitors for enzymes. Herein, we describe the structure-activity relationship for novel xanthine oxidase inhibitors based on indole scaffold. A ser...
  5. Design and synthesis of novel 2-(indol-5-yl)thiazole derivatives as xanthine oxidase inhibitors.

    Bioorganic & Medicinal Chemistry Letters 25(6):1254 (2015) PMID 25704891

    Xanthine oxidase (XO) inhibitors have been widely used for the treatment of gout. Indole rings are frequently used as active scaffold in designing inhibitors for enzymes. Herein, we describe the structure-activity relationship for novel xanthine oxidase inhibitors based on indole scaffold. A ser...
  6. Clinical Implication of p16, Ki-67, and Proliferating Cell Nuclear Antigen Expression in Cervical Neoplasia: Improvement of Diagnostic Accuracy for High-grade Squamous Intraepithelial Lesion and Prediction of Resection Margin Involvement on Conization Specimen.

    Journal of cancer prevention 20(1):70 (2015) PMID 25853106 PMCID PMC4384717

    Cervical intraepithelial neoplasia (CIN) grading is subjective and affected by substantial rates of discordance among pathologists. Although the use of p16INK4a (p16) staining has been proven to improve diagnostic accuracy for high-grade squamous intraepithelial lesion (HSIL), the clinical evide...
  7. Photolytic degradation of sulfamethoxazole and trimethoprim using UV-A, UV-C and vacuum-UV (VUV).

    Journal of Environmental Science and Health, Pa... 50(3):292 (2015) PMID 25594122

    The photolytic degradation of the non-degradable pharmaceuticals sulfamethoxazole (SMX) and trimethoprim (TMP) in an aqueous solution was investigated using three kinds of low-pressure mercury lamp UV-A (352 nm), UV-C (254 nm), and vacuum-UV (VUV, 185 nm and 254 nm). The degradation rates were h...
  8. Identifying a low-risk group for parametrial involvement in microscopic Stage IB1 cervical cancer using criteria from ongoing studies and a new MRI criterion.

    BMC Cancer 15(1):167 (2015) PMID 25885786 PMCID PMC4374417

    There are currently three ongoing studies on less radical surgery in cervical cancer: ConCerv, GOG-278, and SHAPE. The aim of this study was to evaluate the performance of the criteria used in ongoing studies retrospectively and suggest a new, simplified criterion in microscopic Stage IB1 cervic...
  9. Clinical characteristics, management, and outcome of 22 cases of primary hypophysitis.

    Endocrinology and Metabolism 29(4):470 (2014) PMID 25325267

    Primary hypophysitis causes varying degrees of endocrine dysfunction and mass effect. The natural course and best treatment have not been well established. Medical records of 22 patients who had been diagnosed with primary hypophysitis between January 2001 and March 2013 were retrospectively rev...
  10. Clinical characteristics, management, and outcome of 22 cases of primary hypophysitis.

    Endocrinology and Metabolism 29(4):470 (2014) PMID 25325267 PMCID PMC4285029

    Primary hypophysitis causes varying degrees of endocrine dysfunction and mass effect. The natural course and best treatment have not been well established. Medical records of 22 patients who had been diagnosed with primary hypophysitis between January 2001 and March 2013 were retrospectively rev...
  11. Clinical characteristics, management, and outcome of 22 cases of primary hypophysitis.

    Endocrinology and Metabolism 29(4):470 (2014) PMID 25325267 PMCID PMC4285029

    Primary hypophysitis causes varying degrees of endocrine dysfunction and mass effect. The natural course and best treatment have not been well established. Medical records of 22 patients who had been diagnosed with primary hypophysitis between January 2001 and March 2013 were retrospectively rev...
  12. VCS: Tool for Visualizing Copy Number Variation and Single Nucleotide Polymorphism.

    Asian-Australasian journal of animal sciences 27(12):1691 (2014) PMID 25358361 PMCID PMC4213679

    Copy number variation (CNV) or single nucleotide phlyorphism (SNP) is useful genetic resource to aid in understanding complex phenotypes or deseases susceptibility. Although thousands of CNVs and SNPs are currently avaliable in the public databases, they are somewhat difficult to use for analyse...
  13. Genomic selection for adjacent genetic markers of yorkshire pigs using regularized regression approaches.

    Asian-Australasian journal of animal sciences 27(12):1678 (2014) PMID 25358359 PMCID PMC4213677

    This study considers a problem of genomic selection (GS) for adjacent genetic markers of Yorkshire pigs which are typically correlated. The GS has been widely used to efficiently estimate target variables such as molecular breeding values using markers across the entire genome. Recently, GS has ...
  14. Erratum to: Deodorization of pig slurry and characterization of bacterial diversity using 16S rDNA sequence analysis.

    Journal of Microbiology 52(12):1056 (2014) PMID 25363632

  15. Genomic selection for adjacent genetic markers of yorkshire pigs using regularized regression approaches.

    Asian-Australasian journal of animal sciences 27(12):1678 (2014) PMID 25358359 PMCID PMC4213677

    This study considers a problem of genomic selection (GS) for adjacent genetic markers of Yorkshire pigs which are typically correlated. The GS has been widely used to efficiently estimate target variables such as molecular breeding values using markers across the entire genome. Recently, GS has ...
  16. VCS: Tool for Visualizing Copy Number Variation and Single Nucleotide Polymorphism.

    Asian-Australasian journal of animal sciences 27(12):1691 (2014) PMID 25358361 PMCID PMC4213679

    Copy number variation (CNV) or single nucleotide phlyorphism (SNP) is useful genetic resource to aid in understanding complex phenotypes or deseases susceptibility. Although thousands of CNVs and SNPs are currently avaliable in the public databases, they are somewhat difficult to use for analyse...
  17. Deodorization of pig slurry and characterization of bacterial diversity using 16S rDNA sequence analysis.

    Journal of Microbiology 52(11):918 (2014) PMID 25359269

    The concentration of major odor-causing compounds including phenols, indoles, short-chain fatty acids (SCFAs) and branched chain fatty acids (BCFAs) in response to the addition of powdered horse radish (PHR) and spent mushroom compost (SMC) was compared with control non-treated slurry (CNS) samp...
  18. Deodorization of pig slurry and characterization of bacterial diversity using 16S rDNA sequence analysis.

    Journal of Microbiology 52(11):918 (2014) PMID 25359269

    The concentration of major odor-causing compounds including phenols, indoles, short-chain fatty acids (SCFAs) and branched chain fatty acids (BCFAs) in response to the addition of powdered horse radish (PHR) and spent mushroom compost (SMC) was compared with control non-treated slurry (CNS) samp...
  19. Effect of iodine restriction on thyroid function in subclinical hypothyroid patients in an iodine-replete area: a long period observation in a large-scale cohort.

    Thyroid 24(9):1361 (2014) PMID 24892764

    Excessive iodine intake is related to a higher prevalence of hypothyroidism, including subclinical hypothyroidism (SCH), in iodine-replete areas. This study aimed to evaluate the effect of iodine restriction on thyroid function in SCH patients in an iodine-replete area and analyze the relationsh...
  20. Genetic Structure of and Evidence for Admixture between Western and Korean Native Pig Breeds Revealed by Single Nucleotide Polymorphisms.

    Asian-Australasian journal of animal sciences 27(9):1263 (2014) PMID 25178369 PMCID PMC4150192

    Comprehensive information on genetic diversity and introgression is desirable for the design of rational breed improvement and conservation programs. Despite the concerns regarding the genetic introgression of Western pig breeds into the gene pool of the Korean native pig (KNP), the level of thi...