1. Evaluating Approaches for the Diagnosis of Hemodialysis Catheter-Related Bloodstream Infections.

    Clinical Journal of the American Society of Nep... 11(5):847 (2016) PMID 27037271 PMCID PMC4858483

    Guideline-recommended diagnostic criteria for hemodialysis (HD) catheter-related bloodstream infections (CRBSIs) are based on data from indwelling central catheters in patients not on HD and non-HD situations, and upon which peripheral vein cultures are the gold standard. We aimed to examine the...
  2. What Is the Appropriate Meropenem MIC for Screening of Carbapenemase-Producing Enterobacteriaceae in Low-Prevalence Settings?

    Antimicrobial Agents and Chemotherapy 60(3):1556 (2016) PMID 26711746 PMCID PMC4776007

    Infection with carbapenemase-producing Enterobacteriaceae (CPE) has been shown to cause significant illness among hospitalized patients. Given the paucity of treatment options, there is a critical need to stop the spread of CPE. However, screening for the presence of CPE in laboratory settings h...
  3. Cost-Effectiveness Analysis of Six Strategies to Treat Recurrent Clostridium difficile Infection.

    PLoS ONE 11(2):e0149521 (2016) PMID 26901316 PMCID PMC4769325

    To assess the cost-effectiveness of six treatment strategies for patients diagnosed with recurrent Clostridium difficile infection (CDI) in Canada: 1. oral metronidazole; 2. oral vancomycin; 3.oral fidaxomicin; 4. fecal transplantation by enema; 5. fecal transplantation by nasogastric tube; and ...
  4. Vancomycin-variable Enterococcus faecium: in vivo emergence of vancomycin resistance in a vancomycin-susceptible isolate.

    Journal of Clinical Microbiology 52(5):1766 (2014) PMID 24523476 PMCID PMC3993649

    We report the emergence of vancomycin resistance in a patient colonized with a vanA-containing, vanRS-negative isolate of Enterococcus faecium which was initially vancomycin susceptible. This is a previously undescribed mechanism of drug resistance with diagnostic and therapeutic implications.
  5. Reducing antimicrobial therapy for asymptomatic bacteriuria among noncatheterized inpatients: a proof-of-concept study.

    Clinical Infectious Diseases 58(7):980 (2014) PMID 24577290

    This proof-of-concept study demonstrates that no longer routinely reporting urine culture results from noncatheterized medical and surgical inpatients can greatly reduce unnecessary antimicrobial therapy for asymptomatic bacteriuria without significant additional laboratory workload. Larger stud...
  6. A case of rabies encephalitis: new dog, old tricks.

    Neurology 82(12):1101 (2014) PMID 24663232 PMCID PMC3962988

  7. Use of MALDI-TOF for diagnosis of microbial infections.

    Clinical Chemistry 59(10):1435 (2013) PMID 23695295

  8. Indeterminate tcdB using a Clostridium difficile PCR assay: a retrospective cohort study.

    BMC Infectious Diseases 13:324 (2013) PMID 23865713 PMCID PMC3718660

    C. difficile (CD) real-time polymerase chain reaction (PCR) for toxin B gene (tcdB) is more sensitive, and reduces turnaround time when compared to toxin immunoassay. We noted typical amplification curves with high tcdB cycle thresholds (Ct) and low endpoints (Ept) that are labeled negative by t...
  9. Carbapenem-hydrolyzing oxacillinase-48 and oxacillinase-181 in Canada, 2011.

    Emerging Infectious Diseases 19(1):157 (2013) PMID 23261038 PMCID PMC3557990

  10. Pleurostomophora richardsiae - an insidious fungus presenting in a man 44 years after initial inoculation: A case report and review of the literature.

    The Canadian journal of infectious diseases = J... 23(3):110 (2012) PMID 23997775 PMCID PMC3476552

  11. Global analysis of the evolution and mechanism of echinocandin resistance in Candida glabrata.

    PLoS Pathogens 8(5):e1002718 (2012) PMID 22615574 PMCID PMC3355103

    The evolution of drug resistance has a profound impact on human health. Candida glabrata is a leading human fungal pathogen that can rapidly evolve resistance to echinocandins, which target cell wall biosynthesis and are front-line therapeutics for Candida infections. Here, we provide the first ...
  12. New Delhi metallo-β-lactamase-1: local acquisition in Ontario, Canada, and challenges in detection.

    Canadian Medical Association Journal 183(11):1257 (2011) PMID 21624908 PMCID PMC3153514

    New Delhi metallo-β-lactamase-1 (NDM-1) is a recently identified metallo-β-lactamase that confers resistance to carbapenems and all other β-lactam antibiotics, with the exception of aztreonam. NDM-1 is also associated with resistance to many other classes of antibiotics. The enzyme was first ide...
  13. Development of a molecular-beacon-based multi-allelic real-time RT-PCR assay for the detection of human coronavirus causing severe acute respiratory syndrome (SARS-CoV): a general methodology for detecting rapidly mutating viruses.

    Archives of Virology 156(4):671 (2011) PMID 21221674

    Emerging infectious diseases have caused a global effort for development of fast and accurate detection techniques. The rapidly mutating nature of viruses presents a major difficulty, highlighting the need for specific detection of genetically diverse strains. One such infectious agent is SARS-a...
  14. In vitro activity of dalbavancin and telavancin against staphylococci and streptococci isolated from patients in Canadian hospitals: results of the CANWARD 2007-2009 study.

    Diagnostic Microbiology and Infectious Disease 69(3):342 (2011) PMID 21353963

    Two novel lipoglycopeptides, dalbavancin and telavancin, and relevant comparative agents were tested for in vitro activity against clinical isolates of staphylococci and streptococci collected in the cross-Canada surveillance study, CANWARD, in 2007-2009. The rank order of potency (based on MIC(...
  15. The utility of prolonged culture of peritoneal dialysis effluent in the diagnosis and management of peritonitis.

    Advances in peritoneal dialysis. Conference on ... 27:43 (2011) PMID 22073827

    In this prospective study we examined the effect of prolonging cultures of peritoneal dialysis fluid to 21 days. The extended culture period did not lead to any new or clinically important findings, although late culture findings were obtained in a small number of cases. Prolonged culture of the...
  16. A new twist on an old problem. A case of pediatric meningitis caused by multidrug-resistant Streptococcus pneumoniae serotype 19 A.

    Pediatric Infectious Disease Journal 28(1):74 (2009) PMID 19057453

  17. Narrow-spectrum cephalosporin susceptibility testing of Escherichia coli with the BD Phoenix automated system: questionable utility of cephalothin as a predictor of cephalexin susceptibility.

    Journal of Clinical Microbiology 45(11):3762 (2007) PMID 17728468 PMCID PMC2168537

    The resistance of Escherichia coli to cephalothin was found to be overestimated when the Phoenix automated susceptibility system was used to determine resistance compared to reference broth microdilution, a finding that jeopardized the use of cephalexin for first-line treatment of urinary tract ...
  18. Interferon-mediated immunopathological events are associated with atypical innate and adaptive immune responses in patients with severe acute respiratory syndrome.

    Journal of Virology 81(16):8692 (2007) PMID 17537853 PMCID PMC1951379

    It is not understood how immune inflammation influences the pathogenesis of severe acute respiratory syndrome (SARS). One area of strong controversy is the role of interferon (IFN) responses in the natural history of SARS. The fact that the majority of SARS patients recover after relatively mode...
  19. Do your biohazard, bioterror, and emergency planning NOW.

    Medical Laboratory Observer 39(2):38, 40 (2007) PMID 17375845

  20. Bilateral simultaneous Achromobacter xylosoxidans keratitis following penetrating keratoplasty.

    Journal of Cataract & Refractive Surgery 32(12):2149 (2006) PMID 17138001

    We report a case of severe bilateral simultaneous Achromobacter xylosoxidans keratitis following penetrating keratoplasty (PKP) in a patient with graft-versus-host disease. The predisposing factors, clinical features, treatment options, and final visual outcome are reviewed. To our knowledge, th...