1. A Massive Expansion of Effector Genes Underlies Gall-Formation in the Wheat Pest Mayetiola destructor.

    Current Biology 25(5):613 (2015) PMID 25660540

    Gall-forming arthropods are highly specialized herbivores that, in combination with their hosts, produce extended phenotypes with unique morphologies [1]. Many are economically important, and others have improved our understanding of ecology and adaptive radiation [2]. However, the mechanisms th...
  2. A Massive Expansion of Effector Genes Underlies Gall-Formation in the Wheat Pest Mayetiola destructor

    Current Biology (2014)

    • The plant galling Mayetiola destructor genome is replete with effector genes • The SSGP-71 effector gene family is the largest known arthropod gene family. ...
  3. Caudal regulates the spatiotemporal dynamics of pair-rule waves in Tribolium.

    PLoS Genetics 10(10):e1004677 (2014) PMID 25329152 PMCID PMC4199486

    In the short-germ beetle Tribolium castaneum, waves of pair-rule gene expression propagate from the posterior end of the embryo towards the anterior and eventually freeze into stable stripes, partitioning the anterior-posterior axis into segments. Similar waves in vertebrates are assumed to aris...
  4. Caudal regulates the spatiotemporal dynamics of pair-rule waves in Tribolium.

    PLoS Genetics 10(10):e1004677 (2014) PMID 25329152 PMCID PMC4199486

    In the short-germ beetle Tribolium castaneum, waves of pair-rule gene expression propagate from the posterior end of the embryo towards the anterior and eventually freeze into stable stripes, partitioning the anterior-posterior axis into segments. Similar waves in vertebrates are assumed to aris...
  5. Essential role of eIF5-mimic protein in animal development is linked to control of ATF4 expression.

    Nucleic Acids Research 42(16):10321 (2014) PMID 25147208 PMCID PMC4176352

    Translational control of transcription factor ATF4 through paired upstream ORFs (uORFs) plays an important role in eukaryotic gene regulation. While it is typically induced by phosphorylation of eIF2α, ATF4 translation can be also induced by expression of a translational inhibitor protein, eIF5-...
  6. Essential role of eIF5-mimic protein in animal development is linked to control of ATF4 expression.

    Nucleic Acids Research 42(16):10321 (2014) PMID 25147208 PMCID PMC4176352

    Translational control of transcription factor ATF4 through paired upstream ORFs (uORFs) plays an important role in eukaryotic gene regulation. While it is typically induced by phosphorylation of eIF2α, ATF4 translation can be also induced by expression of a translational inhibitor protein, eIF5-...
  7. Essential role of eIF5-mimic protein in animal development is linked to control of ATF4 expression.

    Nucleic Acids Research 42(16):10321 (2014) PMID 25147208 PMCID PMC4176352

    Translational control of transcription factor ATF4 through paired upstream ORFs (uORFs) plays an important role in eukaryotic gene regulation. While it is typically induced by phosphorylation of eIF2α, ATF4 translation can be also induced by expression of a translational inhibitor protein, eIF5-...
  8. Natural attenuation of perchlorate in denitrified groundwater.

    Ground Water 52(1):63 (2014) PMID 23448242

    Monitoring of a well-defined septic system groundwater plume and groundwater discharging to two urban streams located in southern Ontario, Canada, provided evidence of natural attenuation of background low level (ng/L) perchlorate (ClO4⁻) under denitrifying conditions in the field. The septic sy...
  9. Interaction between 25S rRNA A loop and eukaryotic translation initiation factor 5B promotes subunit joining and ensures stringent AUG selection.

    Molecular and Cellular Biology 33(18):3540 (2013) PMID 23836883 PMCID PMC3753867

    In yeast, 25S rRNA makes up the major mass and shape of the 60S ribosomal subunit. During the last step of translation initiation, eukaryotic initiation factor 5B (eIF5B) promotes the 60S subunit joining with the 40S initiation complex (IC). Malfunctional 60S subunits produced by misfolding or m...
  10. Interaction between 25S rRNA A loop and eukaryotic translation initiation factor 5B promotes subunit joining and ensures stringent AUG selection.

    Molecular and Cellular Biology 33(18):3540 (2013) PMID 23836883 PMCID PMC3753867

    In yeast, 25S rRNA makes up the major mass and shape of the 60S ribosomal subunit. During the last step of translation initiation, eukaryotic initiation factor 5B (eIF5B) promotes the 60S subunit joining with the 40S initiation complex (IC). Malfunctional 60S subunits produced by misfolding or m...
  11. Artificial sweeteners in a large Canadian river reflect human consumption in the watershed.

    PLoS ONE 8(12):e82706 (2013) PMID 24349342 PMCID PMC3859606

    Artificial sweeteners have been widely incorporated in human food products for aid in weight loss regimes, dental health protection and dietary control of diabetes. Some of these widely used compounds can pass non-degraded through wastewater treatment systems and are subsequently discharged to g...
  12. The X-Factor: an evaluation of common methods used to analyse major inter-segment kinematics during the golf swing.

    Journal of Sports Sciences 31(11):1156 (2013) PMID 23463985

    A common biomechanical feature of a golf swing, described in various ways in the literature, is the interaction between the thorax and pelvis, often termed the X-Factor. There is no consistent method used within golf biomechanics literature however to calculate these segment interactions. The pu...
  13. The X-Factor: an evaluation of common methods used to analyse major inter-segment kinematics during the golf swing.

    Journal of Sports Sciences 31(11):1156 (2013) PMID 23463985

    A common biomechanical feature of a golf swing, described in various ways in the literature, is the interaction between the thorax and pelvis, often termed the X-Factor. There is no consistent method used within golf biomechanics literature however to calculate these segment interactions. The pu...
  14. Artificial sweeteners in a large Canadian river reflect human consumption in the watershed.

    PLoS ONE 8(12):e82706 (2013) PMID 24349342 PMCID PMC3859606

    Artificial sweeteners have been widely incorporated in human food products for aid in weight loss regimes, dental health protection and dietary control of diabetes. Some of these widely used compounds can pass non-degraded through wastewater treatment systems and are subsequently discharged to g...
  15. A segmentation clock operating in blastoderm and germband stages of Tribolium development.

    Development 139(23):4341 (2012) PMID 23095886 PMCID PMC3509729

    In Drosophila, all segments form in the blastoderm where morphogen gradients spanning the entire anterior-posterior axis of the embryo provide positional information. However, in the beetle Tribolium castaneum and most other arthropods, a number of anterior segments form in the blastoderm, and t...
  16. A segmentation clock operating in blastoderm and germband stages of Tribolium development.

    Development 139(23):4341 (2012) PMID 23095886 PMCID PMC3509729

    In Drosophila, all segments form in the blastoderm where morphogen gradients spanning the entire anterior-posterior axis of the embryo provide positional information. However, in the beetle Tribolium castaneum and most other arthropods, a number of anterior segments form in the blastoderm, and t...
  17. Asymmetrically expressed axin required for anterior development in Tribolium.

    PNAS 109(20):7782 (2012) PMID 22552230 PMCID PMC3356623

    Canonical Wnt signaling has been implicated in an AP axis polarizing mechanism in most animals, despite limited evidence from arthropods. In the long-germ insect, Drosophila, Wnt signaling is not required for global AP patterning, but in short-germ insects including Tribolium castaneum, loss of ...
  18. Asymmetrically expressed axin required for anterior development in Tribolium.

    PNAS 109(20):7782 (2012) PMID 22552230 PMCID PMC3356623

    Canonical Wnt signaling has been implicated in an AP axis polarizing mechanism in most animals, despite limited evidence from arthropods. In the long-germ insect, Drosophila, Wnt signaling is not required for global AP patterning, but in short-germ insects including Tribolium castaneum, loss of ...
  19. Genomic and proteomic studies on the effects of the insect growth regulator diflubenzuron in the model beetle species Tribolium castaneum.

    Insect Biochemistry and Molecular Biology 42(4):264 (2012) PMID 22212827

    Several benzoylphenyl urea-derived insecticides such as diflubenzuron (DFB, Dimilin) are in wide use to control various insect pests. Although this class of compounds is known to disrupt molting and to affect chitin content, their precise mode of action is still not understood. To gain a broader...
  20. Genomic and proteomic studies on the effects of the insect growth regulator diflubenzuron in the model beetle species Tribolium castaneum.

    Insect Biochemistry and Molecular Biology 42(4):264 (2012) PMID 22212827

    Several benzoylphenyl urea-derived insecticides such as diflubenzuron (DFB, Dimilin) are in wide use to control various insect pests. Although this class of compounds is known to disrupt molting and to affect chitin content, their precise mode of action is still not understood. To gain a broader...