1. A platform for rapid exploration of aging and diseases in a naturally short-lived vertebrate.

    Cell 160(5):1013 (2015) PMID 25684364 PMCID PMC4344913

    Aging is a complex process that affects multiple organs. Modeling aging and age-related diseases in the lab is challenging because classical vertebrate models have relatively long lifespans. Here, we develop the first platform for rapid exploration of age-dependent traits and diseases in vertebr...
  2. A platform for rapid exploration of aging and diseases in a naturally short-lived vertebrate.

    Cell 160(5):1013 (2015) PMID 25684364 PMCID PMC4344913

    Aging is a complex process that affects multiple organs. Modeling aging and age-related diseases in the lab is challenging because classical vertebrate models have relatively long lifespans. Here, we develop the first platform for rapid exploration of age-dependent traits and diseases in vertebr...
  3. A Platform for Rapid Exploration of Aging and Diseases in a Naturally Short-Lived Vertebrate

    Cell 160(5):1013 (2015)

    Aging is a complex process that affects multiple organs. Modeling aging and age-related diseases in the lab is challenging because classical vertebrate models have relatively long lifespans. Here, we develop the first platform for rapid exploration of age-dependent traits and diseases ...
  4. A platform for rapid exploration of aging and diseases in a naturally short-lived vertebrate.

    Cell 160(5):1013 (2015) PMID 25684364

    Aging is a complex process that affects multiple organs. Modeling aging and age-related diseases in the lab is challenging because classical vertebrate models have relatively long lifespans. Here, we develop the first platform for rapid exploration of age-dependent traits and diseases in vertebr...
  5. Inhibition of pluripotency networks by the rb tumor suppressor restricts reprogramming and tumorigenesis.

    Cell Stem Cell 16(1):39 (2015) PMID 25467916

    Mutations in the retinoblastoma tumor suppressor gene Rb are involved in many forms of human cancer. In this study, we investigated the early consequences of inactivating Rb in the context of cellular reprogramming. We found that Rb inactivation promotes the reprogramming of differentiated cells...
  6. Inhibition of pluripotency networks by the rb tumor suppressor restricts reprogramming and tumorigenesis.

    Cell Stem Cell 16(1):39 (2015) PMID 25467916

    Mutations in the retinoblastoma tumor suppressor gene Rb are involved in many forms of human cancer. In this study, we investigated the early consequences of inactivating Rb in the context of cellular reprogramming. We found that Rb inactivation promotes the reprogramming of differentiated cells...
  7. Inhibition of pluripotency networks by the Rb tumor suppressor restricts reprogramming and tumorigenesis.

    Cell Stem Cell 16(1):39 (2015) PMID 25467916

    Mutations in the retinoblastoma tumor suppressor gene Rb are involved in many forms of human cancer. In this study, we investigated the early consequences of inactivating Rb in the context of cellular reprogramming. We found that Rb inactivation promotes the reprogramming of differentiated cells...
  8. Inhibition of pluripotency networks by the Rb tumor suppressor restricts reprogramming and tumorigenesis.

    Cell Stem Cell 16(1):39 (2015) PMID 25467916

    Mutations in the retinoblastoma tumor suppressor gene Rb are involved in many forms of human cancer. In this study, we investigated the early consequences of inactivating Rb in the context of cellular reprogramming. We found that Rb inactivation promotes the reprogramming of differentiated cells...
  9. Inhibition of pluripotency networks by the Rb tumor suppressor restricts reprogramming and tumorigenesis.

    Cell Stem Cell 16(1):39 (2015) PMID 25467916 PMCID PMC4389904

    Mutations in the retinoblastoma tumor suppressor gene Rb are involved in many forms of human cancer. In this study, we investigated the early consequences of inactivating Rb in the context of cellular reprogramming. We found that Rb inactivation promotes the reprogramming of differentiated cells...
  10. Inhibition of pluripotency networks by the rb tumor suppressor restricts reprogramming and tumorigenesis.

    Cell Stem Cell 16(1):39 (2015) PMID 25467916

    Mutations in the retinoblastoma tumor suppressor gene Rb are involved in many forms of human cancer. In this study, we investigated the early consequences of inactivating Rb in the context of cellular reprogramming. We found that Rb inactivation promotes the reprogramming of differentiated cells...
  11. Reversibility of Defective Hematopoiesis Caused by Telomere Shortening in Telomerase Knockout Mice.

    PLoS ONE 10(7):e0131722 (2015) PMID 26133370 PMCID PMC4489842

    Telomere shortening is common in bone marrow failure syndromes such as dyskeratosis congenita (DC), aplastic anemia (AA) and myelodysplastic syndromes (MDS). However, improved knowledge of the lineage-specific consequences of telomere erosion and restoration of telomere length in hematopoietic p...
  12. Proteostatic Control of Telomerase Function through TRiC-Mediated Folding of TCAB1

    Cell 159(6):1389 (2014)

    Telomere maintenance by telomerase is impaired in the stem cell disease dyskeratosis congenita and during human aging. Telomerase depends upon a complex pathway for enzyme assembly, localization in Cajal bodies, and association with telomeres. Here, we identify the chaperonin CCT/TRiC ...
  13. Proteostatic control of telomerase function through TRiC-mediated folding of TCAB1.

    Cell 159(6):1389 (2014) PMID 25467444

    Telomere maintenance by telomerase is impaired in the stem cell disease dyskeratosis congenita and during human aging. Telomerase depends upon a complex pathway for enzyme assembly, localization in Cajal bodies, and association with telomeres. Here, we identify the chaperonin CCT/TRiC as a criti...
  14. Proteostatic control of telomerase function through TRiC-mediated folding of TCAB1.

    Cell 159(6):1389 (2014) PMID 25467444

    Telomere maintenance by telomerase is impaired in the stem cell disease dyskeratosis congenita and during human aging. Telomerase depends upon a complex pathway for enzyme assembly, localization in Cajal bodies, and association with telomeres. Here, we identify the chaperonin CCT/TRiC as a criti...
  15. Proteostatic control of telomerase function through TRiC-mediated folding of TCAB1.

    Cell 159(6):1389 (2014) PMID 25467444

    Telomere maintenance by telomerase is impaired in the stem cell disease dyskeratosis congenita and during human aging. Telomerase depends upon a complex pathway for enzyme assembly, localization in Cajal bodies, and association with telomeres. Here, we identify the chaperonin CCT/TRiC as a criti...
  16. Proteostatic control of telomerase function through TRiC-mediated folding of TCAB1.

    Cell 159(6):1389 (2014) PMID 25467444

    Telomere maintenance by telomerase is impaired in the stem cell disease dyskeratosis congenita and during human aging. Telomerase depends upon a complex pathway for enzyme assembly, localization in Cajal bodies, and association with telomeres. Here, we identify the chaperonin CCT/TRiC as a criti...
  17. Proteostatic Control of Telomerase Function through TRiC-Mediated Folding of TCAB1.

    Cell 159(6):1389 (2014) PMID 25467444

    Telomere maintenance by telomerase is impaired in the stem cell disease dyskeratosis congenita and during human aging. Telomerase depends upon a complex pathway for enzyme assembly, localization in Cajal bodies, and association with telomeres. Here, we identify the chaperonin CCT/TRiC as a criti...
  18. Proteostatic control of telomerase function through TRiC-mediated folding of TCAB1.

    Cell 159(6):1389 (2014) PMID 25467444 PMCID PMC4329143

    Telomere maintenance by telomerase is impaired in the stem cell disease dyskeratosis congenita and during human aging. Telomerase depends upon a complex pathway for enzyme assembly, localization in Cajal bodies, and association with telomeres. Here, we identify the chaperonin CCT/TRiC as a criti...
  19. Proteostatic control of telomerase function through TRiC-mediated folding of TCAB1.

    Cell 159(6):1389 (2014) PMID 25467444

    Telomere maintenance by telomerase is impaired in the stem cell disease dyskeratosis congenita and during human aging. Telomerase depends upon a complex pathway for enzyme assembly, localization in Cajal bodies, and association with telomeres. Here, we identify the chaperonin CCT/TRiC as a criti...
  20. Proteostatic control of telomerase function through TRiC-mediated folding of TCAB1.

    Cell 159(6):1389 (2014) PMID 25467444 PMCID PMC4329143

    Telomere maintenance by telomerase is impaired in the stem cell disease dyskeratosis congenita and during human aging. Telomerase depends upon a complex pathway for enzyme assembly, localization in Cajal bodies, and association with telomeres. Here, we identify the chaperonin CCT/TRiC as a criti...