1. Real-time intravital imaging establishes tumor-associated macrophages as the extraskeletal target of bisphosphonate action in cancer.

    Cancer Discovery 5(1):35 (2015) PMID 25312016 PMCID PMC4293349

    Recent clinical trials have shown that bisphosphonate drugs improve breast cancer patient survival independent of their antiresorptive effects on the skeleton. However, because bisphosphonates bind rapidly to bone mineral, the exact mechanisms of their antitumor action, particularly on cells out...
  2. Real-time intravital imaging establishes tumor-associated macrophages as the extraskeletal target of bisphosphonate action in cancer.

    Cancer Discovery 5(1):35 (2015) PMID 25312016

    Recent clinical trials have shown that bisphosphonate drugs improve breast cancer patient survival independent of their antiresorptive effects on the skeleton. However, because bisphosphonates bind rapidly to bone mineral, the exact mechanisms of their antitumor action, particularly on cells out...
  3. Real-time intravital imaging establishes tumor-associated macrophages as the extraskeletal target of bisphosphonate action in cancer.

    Cancer Discovery 5(1):35 (2015) PMID 25312016 PMCID PMC4293349

    Recent clinical trials have shown that bisphosphonate drugs improve breast cancer patient survival independent of their antiresorptive effects on the skeleton. However, because bisphosphonates bind rapidly to bone mineral, the exact mechanisms of their antitumor action, particularly on cells out...
  4. Real-time intravital imaging establishes tumor-associated macrophages as the extraskeletal target of bisphosphonate action in cancer.

    Cancer Discovery 5(1):35 (2015) PMID 25312016

    Recent clinical trials have shown that bisphosphonate drugs improve breast cancer patient survival independent of their antiresorptive effects on the skeleton. However, because bisphosphonates bind rapidly to bone mineral, the exact mechanisms of their antitumor action, particularly on cells out...
  5. Real-time intravital imaging establishes tumor-associated macrophages as the extraskeletal target of bisphosphonate action in cancer.

    Cancer Discovery 5(1):35 (2015) PMID 25312016

    Recent clinical trials have shown that bisphosphonate drugs improve breast cancer patient survival independent of their antiresorptive effects on the skeleton. However, because bisphosphonates bind rapidly to bone mineral, the exact mechanisms of their antitumor action, particularly on cells out...
  6. ID4 controls mammary stem cells and marks breast cancers with a stem cell-like phenotype.

    Nature Communications 6:6548 (2015) PMID 25813983

    Basal-like breast cancer (BLBC) is a heterogeneous disease with poor prognosis; however, its cellular origins and aetiology are poorly understood. In this study, we show that inhibitor of differentiation 4 (ID4) is a key regulator of mammary stem cell self-renewal and marks a subset of BLBC with...
  7. Real-time intravital imaging establishes tumor-associated macrophages as the extraskeletal target of bisphosphonate action in cancer.

    Cancer Discovery 5(1):35 (2015) PMID 25312016 PMCID PMC4293349

    Recent clinical trials have shown that bisphosphonate drugs improve breast cancer patient survival independent of their antiresorptive effects on the skeleton. However, because bisphosphonates bind rapidly to bone mineral, the exact mechanisms of their antitumor action, particularly on cells out...
  8. Cathepsin C is a tissue-specific regulator of squamous carcinogenesis.

    Genes & Development 27(19):2086 (2013) PMID 24065739 PMCID PMC3850093

    Serine and cysteine cathepsin (Cts) proteases are an important class of intracellular and pericellular enzymes mediating multiple aspects of tumor development. Emblematic of these is CtsB, reported to play functionally significant roles during pancreatic islet and mammary carcinogenesis. CtsC, o...
  9. Cathepsin C is a tissue-specific regulator of squamous carcinogenesis.

    Genes & Development 27(19):2086 (2013) PMID 24065739 PMCID PMC3850093

    Serine and cysteine cathepsin (Cts) proteases are an important class of intracellular and pericellular enzymes mediating multiple aspects of tumor development. Emblematic of these is CtsB, reported to play functionally significant roles during pancreatic islet and mammary carcinogenesis. CtsC, o...
  10. FcRgamma activation regulates inflammation-associated squamous carcinogenesis.

    Cancer Cell 17(2):121 (2010) PMID 20138013 PMCID PMC3082507

    Chronically activated leukocytes recruited to premalignant tissues functionally contribute to cancer development; however, mechanisms underlying pro- versus anti-tumor programming of neoplastic tissues by immune cells remain obscure. Using the K14-HPV16 mouse model of squamous carcinogenesis, we...
  11. FcRgamma activation regulates inflammation-associated squamous carcinogenesis.

    Cancer Cell 17(2):121 (2010) PMID 20138013 PMCID PMC3082507

    Chronically activated leukocytes recruited to premalignant tissues functionally contribute to cancer development; however, mechanisms underlying pro- versus anti-tumor programming of neoplastic tissues by immune cells remain obscure. Using the K14-HPV16 mouse model of squamous carcinogenesis, we...
  12. Stromal regulation of vessel stability by MMP14 and TGFbeta.

    Disease Models & Mechanisms 3(5-6):317 (2010) PMID 20223936 PMCID PMC2860851

    Innate regulatory networks within organs maintain tissue homeostasis and facilitate rapid responses to damage. We identified a novel pathway regulating vessel stability in tissues that involves matrix metalloproteinase 14 (MMP14) and transforming growth factor beta 1 (TGFbeta(1)). Whereas plasma...
  13. FcRγ Activation Regulates Inflammation-Associated Squamous Carcinogenesis

    Cancer Cell 17(2):121 (2010)

    Chronically activated leukocytes recruited to premalignant tissues functionally contribute to cancer development; however, mechanisms underlying pro- versus anti-tumor programming of neoplastic tissues by immune cells remain obscure. Using the K14-HPV16 mouse model of squamous carcinogenesi...
  14. Redefining the expression and function of the inhibitor of differentiation 1 in mammary gland development.

    PLoS ONE 5(8):e11947 (2010) PMID 20689821 PMCID PMC2914758

    The accumulation of poorly differentiated cells is a hallmark of breast neoplasia and progression. Thus an understanding of the factors controlling mammary differentiation is critical to a proper understanding of breast tumourigenesis. The Inhibitor of Differentiation 1 (Id1) protein has well do...
  15. FcRγ Activation Regulates Inflammation-Associated Squamous Carcinogenesis

    Cancer Cell 17(2):121 (2010) PMID 20138013 PMCID PMC3082507

    Chronically activated leukocytes recruited to premalignant tissues functionally contribute to cancer development; however, mechanisms underlying pro- versus anti-tumor programming of neoplastic tissues by immune cells remain obscure. Using the K14-HPV16 mouse model of squamous carcinogenesi...
  16. Redefining the expression and function of the inhibitor of differentiation 1 in mammary gland development.

    PLoS ONE 5(8):e11947 (2010) PMID 20689821 PMCID PMC2914758

    The accumulation of poorly differentiated cells is a hallmark of breast neoplasia and progression. Thus an understanding of the factors controlling mammary differentiation is critical to a proper understanding of breast tumourigenesis. The Inhibitor of Differentiation 1 (Id1) protein has well do...
  17. Tumor-induced anorexia and weight loss are mediated by the TGF-beta superfamily cytokine MIC-1.

    Nature Medicine 13(11):1333 (2007) PMID 17982462

    Anorexia and weight loss are part of the wasting syndrome of late-stage cancer, are a major cause of morbidity and mortality in cancer, and are thought to be cytokine mediated. Macrophage inhibitory cytokine-1 (MIC-1) is produced by many cancers. Examination of sera from individuals with advance...
  18. Tumor-induced anorexia and weight loss are mediated by the TGF-beta superfamily cytokine MIC-1.

    Nature Medicine 13(11):1333 (2007) PMID 17982462

    Anorexia and weight loss are part of the wasting syndrome of late-stage cancer, are a major cause of morbidity and mortality in cancer, and are thought to be cytokine mediated. Macrophage inhibitory cytokine-1 (MIC-1) is produced by many cancers. Examination of sera from individuals with advance...
  19. The propeptide mediates formation of stromal stores of PROMIC-1: role in determining prostate cancer outcome.

    Cancer Research 65(6):2330 (2005) PMID 15781647

    The extracellular matrix (ECM) is a reservoir of cellular binding proteins and growth factors that are critical for normal cell behavior, and aberrations in the ECM invariably accompany malignancies such as prostate cancer. Carcinomas commonly overexpress macrophage inhibitory cytokine 1 (MIC-1)...
  20. The propeptide mediates formation of stromal stores of PROMIC-1: role in determining prostate cancer outcome.

    Cancer Research 65(6):2330 (2005) PMID 15781647

    The extracellular matrix (ECM) is a reservoir of cellular binding proteins and growth factors that are critical for normal cell behavior, and aberrations in the ECM invariably accompany malignancies such as prostate cancer. Carcinomas commonly overexpress macrophage inhibitory cytokine 1 (MIC-1)...