1. Ube3a imprinting impairs circadian robustness in angelman syndrome models.

    Current Biology 25(5):537 (2015) PMID 25660546 PMCID PMC4348236

    The paternal allele of Ube3a is silenced by imprinting in neurons, and Angelman syndrome (AS) is a disorder arising from a deletion or mutation of the maternal Ube3a allele, which thereby eliminates Ube3a neuronal expression. Sleep disorders such as short sleep duration and increased sleep onset...
  2. Circadian disruption leads to insulin resistance and obesity.

    Current Biology 23(5):372 (2013) PMID 23434278 PMCID PMC3595381

    Disruption of circadian (daily) timekeeping enhances the risk of metabolic syndrome, obesity, and type 2 diabetes. While clinical observations have suggested that insulin action is not constant throughout the 24 hr cycle, its magnitude and periodicity have not been assessed. Moreover, when circa...
  3. Circadian Disruption Leads to Insulin Resistance and Obesity

    Current Biology 23(5):372 (2013)

    Background Disruption of circadian (daily) timekeeping enhances the risk of metabolic syndrome, obesity, and type 2 diabetes. While clinical observations have suggested that insulin action is not constant throughout the 24 hr cycle, its magnitude and periodicity have not been...
  4. Immunogenicity of four complementary deoxyribonucleic acid fragments from rabbit zona pellucida 3 and their effects on fertility.

    Fertility and Sterility 87(2):381 (2007) PMID 17113087

    To evaluate the exact region in different exons of rabbit zona pellucida (ZP)3 involved in recognition and binding between sperm and the ZP. Prospective study of a female immunocontraceptive. State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences. BALB/C ...
  5. Immunogenicity of four complementary deoxyribonucleic acid fragments from rabbit zona pellucida 3 and their effects on fertility

    Fertility and Sterility 87(2):381 (2007)

    Objective To evaluate the exact region in different exons of rabbit zona pellucida (ZP)3 involved in recognition and binding between sperm and the ZP.
  6. Apoptosis and tumor inhibition induced by human chorionic gonadotropin beta in mouse breast carcinoma.

    Journal of Molecular Medicine (Berlin, Germany) 84(11):933 (2006) PMID 16924466

    For many breast cancer patients, human chorionic gonadotropin beta (hCGbeta), which is a subunit of a hormone produced by the trophoblast and is essential for maintaining pregnancy, is expressed in the breast cancer cells. However, the mechanism as to how the CGbeta in cell affects the cancer de...
  7. M and N proteins of SARS coronavirus induce apoptosis in HPF cells.

    Cell Biology and Toxicology 22(5):313 (2006) PMID 16845612

    SARS-associated coronavirus (SARS-CoV) induced cell apoptosis and its structural proteins may play a role in this process. To determine whether the structural proteins M and N of SARS-CoV induce apoptosis. We investigated human pulmonary fibroblast (HPF) cells, were transfected with plasmids con...
  8. The expression of membrane protein augments the specific responses induced by SARS-CoV nucleocapsid DNA immunization.

    Molecular Immunology 43(11):1791 (2006) PMID 16423399

    Nucleocapsid protein plays a critical role in SARS-CoV pathogenesis, and high-level anti-nucleocapsid antibodies are detected in the patients infected by severe acute respiratory syndrome-associated coronavirus (SARS-CoV). Several studies have shown that there exists an interaction between nucle...
  9. Evaluation of the contraceptive potential of brZPCp vaccine in BALB/c mice: their safety and efficacy.

    DNA and Cell Biology 25(2):87 (2006) PMID 16460232

    In this study we have examined the potential ability of Microtus branditi partial ZPC (brZPCp) cDNA sequence (436-1150 nt) as a target for immunocontraception. Immunogenicity studies and fertility trials were performed in BALB/c mice using recombinant construction pCR3.1-brZPC(p). ELISA outcome ...
  10. The expression of membrane protein augments the specific responses induced by SARS-CoV nucleocapsid DNA immunization

    Molecular Immunology 43(11):1791 (2006)

    Nucleocapsid protein plays a critical role in SARS-CoV pathogenesis, and high-level anti-nucleocapsid antibodies are detected in the patients infected by severe acute respiratory syndrome-associated coronavirus (SARS-CoV). Several studies have shown that there exists an interaction between ...
  11. Oral feeding and nasal instillation immunization with Microtus brandti lactate dehydrogenase C epitope DNA vaccine reduces fertility in mice via specific antibody responses.

    Fertility and Sterility 84(3):781 (2005) PMID 16169425

    The immune responses induced by Microtus brandti lactate dehydrogenase C4 DNA vaccine via oral feeding and nasal instillation in mouse were investigated. The number of newborns of the vaccinated mice was statistically significantly reduced compared with the control mice, but the vaccine failed t...
  12. The mouse chorionic gonadotropin beta-subunit-like (muCG beta l) molecule produced by tumor cells elicits the switch of T-cell immunity response from TH2 to TH1 in mice immunized with DNA vaccine based on rhesus monkey homologous CG beta (rmCG beta).

    Journal of Gene Medicine 7(1):87 (2005) PMID 15517553

    CG beta is expressed not only in placenta, but also in a wide range of tumors. To study DNA vaccine based on xenogeneic CG beta for cancer immuno-therapy, we investigated whether rhesus monkey CG beta (rmCG beta) DNA vaccine could induce protective T-cell responses and humoral responses in mouse...
  13. Oral feeding and nasal instillation immunization withMicrotus brandtilactate dehydrogenase c epitope DNA vaccine reduces fertility in mice via specific antibody responses

    Fertility and Sterility 84(3):781 (2005)

    The immune responses induced by Microtus brandti lactate dehydrogenase C4 DNA vaccine via oral feeding and nasal instillation in mouse were investigated. The number of newborns of the vaccinated mice was statistically significantly reduced compared with the control mice, but the vacc...