1. Severity and Frequency of Proximal Tubule Injury Determines Renal Prognosis.

    Journal of the American Society of Nephrology 27(8):2393 (2016) PMID 26701981 PMCID PMC4978049

    AKI increases the risk of developing CKD, but the mechanisms linking AKI to CKD remain unclear. Because proximal tubule injury is the mainstay of AKI, we postulated that proximal tubule injury triggers features of CKD. We generated a novel mouse model to induce proximal tubule-specific adjustabl...
  2. Case of lumbar disc hernia caused in the left L4 and L5 dermatomes after herpes zoster infection in the right L2 and L3 dermatomes.

    Journal of Dermatology 43(8):977 (2016) PMID 26892833

  3. Ubr3, a Novel Modulator of Hh Signaling Affects the Degradation of Costal-2 and Kif7 through Poly-ubiquitination.

    PLoS Genetics 12(5):e1006054 (2016) PMID 27195754 PMCID PMC4873228

    Hedgehog (Hh) signaling regulates multiple aspects of metazoan development and tissue homeostasis, and is constitutively active in numerous cancers. We identified Ubr3, an E3 ubiquitin ligase, as a novel, positive regulator of Hh signaling in Drosophila and vertebrates. Hh signaling regulates th...
  4. Clinical outcome of urachal cancer in Japanese patients.

    International Journal of Clinical Oncology 21(1):133 (2016) PMID 26138265

    The outcome of treatment of Japanese patients with urachal cancer is not well known. The purpose of this study is to clarify the characteristics and outcomes of Japanese patients with urachal cancer. The medical records of patients with urachal cancer who were treated in our hospital between 199...
  5. WAC Regulates mTOR Activity by Acting as an Adaptor for the TTT and Pontin/Reptin Complexes.

    Developmental Cell 36(2):139 (2016) PMID 26812014 PMCID PMC4730548

    The ability to sense energy status is crucial in the regulation of metabolism via the mechanistic Target of Rapamycin Complex 1 (mTORC1). The assembly of the TTT-Pontin/Reptin complex is responsive to changes in energy status. Under energy-sufficient conditions, the TTT-Pontin/Reptin complex pro...
  6. Clinical Value of 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Upper Tract Urothelial Carcinoma: Impact on Detection of Metastases and Patient Management.

    Urologia Internationalis 96(1):65 (2016) PMID 26044598

    To determine the diagnostic accuracy of 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) for detecting metastasis and its impact on patient management with upper tract urothelial carcinoma (UTUC). Consecutive patients with UTUC underwent 18F-FDG PET/CT a...
  7. Efficacy and Safety Profile of Enzalutamide for Japanese Patients with Castration-resistant Prostate Cancer.

    Anticancer Research 36(1):361 (2016) PMID 26722066

    Enzalutamide is a novel, non-steroidal anti-androgen that was approved for the treatment of patients with castration-resistant prostate cancer (CRPC) in 2014 in Japan. To assess the potency of enzalutamide treatment in Japan, we performed a pilot retrospective study. Among 91 patients who receiv...
  8. Loss of Frataxin induces iron toxicity, sphingolipid synthesis, and Pdk1/Mef2 activation, leading to neurodegeneration.

    eLife 5 (2016) PMID 27343351 PMCID PMC4956409

    Mutations in Frataxin (FXN) cause Friedreich's ataxia (FRDA), a recessive neurodegenerative disorder. Previous studies have proposed that loss of FXN causes mitochondrial dysfunction, which triggers elevated reactive oxygen species (ROS) and leads to the demise of neurons. Here we describe a ROS...
  9. Clinical response to induction chemotherapy predicts improved survival outcome in urothelial carcinoma with clinical lymph nodal metastasis treated by consolidative surgery.

    International Journal of Clinical Oncology 20(6):1171 (2015) PMID 25953680

    To determine the indications for post-chemotherapy consolidative surgery in patients with clinical lymph node (LN) metastatic (cN+) urothelial carcinoma (UC). Sixty UC patients with measurable cN+ but without detectable systemic visceral/bone dissemination received induction platinum-based chemo...
  10. Surveillance policy for Japanese patients with stage I testicular germ cell cancer in the multi-detector computed tomography era.

    International Journal of Clinical Oncology 20(6):1198 (2015) PMID 25893862

    The outcome of surveillance for Japanese patients with clinical stage I testicular germ cell cancer (GCC) was investigated in the multi-detector computed tomography (MDCT) era. The medical records of 92 Japanese patients with stage I GCC, who received treatment in our institution between March 1...
  11. Morgan’s Legacy: Fruit Flies and the Functional Annotation of Conserved Genes

    Cell 163(3):772 (2015)

  12. Morgan's legacy: fruit flies and the functional annotation of conserved genes.

    Cell 163(1):12 (2015) PMID 26406362 PMCID PMC4783153

    In 1915, "The Mechanism of Mendelian Heredity" was published by four prominent Drosophila geneticists. They discovered that genes form linkage groups on chromosomes inherited in a Mendelian fashion and laid the genetic foundation that promoted Drosophila as a model organism. Flies continue to of...
  13. Band-like lipoatrophy on the forearm by injected triamcinolone acetonide to wrist joint.

    Journal of Dermatology 42(9):934 (2015) PMID 25988367

  14. Pyoderma gangrenosum and annular erythema associated with Sjögren's syndrome controlled with minocycline.

    Journal of Dermatology 42(8):834 (2015) PMID 25899670

  15. Impaired Mitochondrial Energy Production Causes Light-Induced Photoreceptor Degeneration Independent of Oxidative Stress.

    PLoS Biology 13(7):e1002197 (2015) PMID 26176594 PMCID PMC4503542

    Two insults often underlie a variety of eye diseases including glaucoma, optic atrophy, and retinal degeneration--defects in mitochondrial function and aberrant Rhodopsin trafficking. Although mitochondrial defects are often associated with oxidative stress, they have not been linked to Rhodopsi...
  16. Correction: the retromer complex is required for rhodopsin recycling and its loss leads to photoreceptor degeneration.

    PLoS Biology 13(5):e1002170 (2015) PMID 26020534 PMCID PMC4447419

    [This corrects the article DOI: 10.1371/journal.pbio.1001847.].
  17. MP26-10 A PROSPECTIVE RANDOMIZED TRIAL OF INTRAVESICAL BACILLUS CALMETTE-GUERIN THERAPY WITH THE TOKYO172 VERSUS CONNAUGHT STRAIN FOR NON-MUSCLE INVASIVE BLADDER CANCER

    The Journal of Urology 193(4):e297 (2015)

  18. A voltage-gated calcium channel regulates lysosomal fusion with endosomes and autophagosomes and is required for neuronal homeostasis.

    PLoS Biology 13(3):e1002103 (2015) PMID 25811491 PMCID PMC4374850

    Autophagy helps deliver sequestered intracellular cargo to lysosomes for proteolytic degradation and thereby maintains cellular homeostasis by preventing accumulation of toxic substances in cells. In a forward mosaic screen in Drosophila designed to identify genes required for neuronal function ...
  19. Diagnostic performance and safety of a three-dimensional 14-core systematic biopsy method.

    BJU International 115(3):412 (2015) PMID 24731079

    To investigate the diagnostic performance and safety of a three-dimensional 14-core biopsy (3D14PBx) method, which is a combination of the transrectal six-core and transperineal eight-core biopsy methods. Between December 2005 and August 2010, 1103 men underwent 3D14PBx at our institutions and w...
  20. Fruit flies in biomedical research.

    Genetics 199(3):639 (2015) PMID 25624315 PMCID PMC4349060

    Many scientists complain that the current funding situation is dire. Indeed, there has been an overall decline in support in funding for research from the National Institutes of Health and the National Science Foundation. Within the Drosophila field, some of us question how long this funding cru...