1. The P2Y₂ receptor promotes Wnt3a- and EGF-induced epithelial tubular formation by IEC6 cells by binding to integrins.

    Journal of Cell Science 128(11):2156 (2015) PMID 25908848

    Epithelial tubular structures are essential units in various organs. Here, we used rat intestinal epithelial IEC6 cells to investigate tubulogenesis and we found that tubular formation was induced by a combination of Wnt3a and EGF signaling during three-dimensional culture. Wnt3a and EGF induced...
  2. Drosophila Sugar Receptors in Sweet Taste Perception, Olfaction, and Internal Nutrient Sensing

    Current Biology 25(5):621 (2015) PMID 25702577

    Identification of nutritious compounds is dependent on expression of specific taste receptors in appropriate taste-cell types [1]. In contrast to mammals, which rely on a single, broadly tuned heterodimeric sugar receptor [2], the Drosophila genome harbors a small subfamily of eight, c...
  3. Drosophila sugar receptors in sweet taste perception, olfaction, and internal nutrient sensing.

    Current Biology 25(5):621 (2015) PMID 25702577

    Identification of nutritious compounds is dependent on expression of specific taste receptors in appropriate taste-cell types [1]. In contrast to mammals, which rely on a single, broadly tuned heterodimeric sugar receptor [2], the Drosophila genome harbors a small subfamily of eight, closely rel...
  4. Effect of CTGF/CCN2 on osteo/cementoblastic and fibroblastic differentiation of a human periodontal ligament stem/progenitor cell line.

    Journal Of Cellular Physiology 230(1):150 (2015) PMID 24905848

    Appropriate mechanical loading during occlusion and mastication play an important role in maintaining the homeostasis of periodontal ligament (PDL) tissue. Connective tissue growth factor (CTGF/CCN2), a matricellular protein, is known to upregulate extracellular matrix production, including coll...
  5. Effect of CTGF/CCN2 on osteo/cementoblastic and fibroblastic differentiation of a human periodontal ligament stem/progenitor cell line.

    Journal Of Cellular Physiology 230(1):150 (2015) PMID 24905848

    Appropriate mechanical loading during occlusion and mastication play an important role in maintaining the homeostasis of periodontal ligament (PDL) tissue. Connective tissue growth factor (CTGF/CCN2), a matricellular protein, is known to upregulate extracellular matrix production, including coll...
  6. Effect of CTGF/CCN2 on osteo/cementoblastic and fibroblastic differentiation of a human periodontal ligament stem/progenitor cell line.

    Journal Of Cellular Physiology 230(1):150 (2015) PMID 24905848

    Appropriate mechanical loading during occlusion and mastication play an important role in maintaining the homeostasis of periodontal ligament (PDL) tissue. Connective tissue growth factor (CTGF/CCN2), a matricellular protein, is known to upregulate extracellular matrix production, including coll...
  7. Semaphorin 3A induces mesenchymal-stem-like properties in human periodontal ligament cells.

    Stem Cells and Development 23(18):2225 (2014) PMID 24380401 PMCID PMC4155480

    Periodontal ligament stem cells (PDLSCs) have recently been proposed as a novel option in periodontal regenerative therapy. However, one of the issues is the difficulty of stably generating PDLSCs because of the variation of stem cell potential between donors. Here, we show that Semaphorin 3A (S...
  8. Semaphorin 3A induces mesenchymal-stem-like properties in human periodontal ligament cells.

    Stem Cells and Development 23(18):2225 (2014) PMID 24380401 PMCID PMC4155480

    Periodontal ligament stem cells (PDLSCs) have recently been proposed as a novel option in periodontal regenerative therapy. However, one of the issues is the difficulty of stably generating PDLSCs because of the variation of stem cell potential between donors. Here, we show that Semaphorin 3A (S...
  9. The roles of calcium-sensing receptor and calcium channel in osteogenic differentiation of undifferentiated periodontal ligament cells.

    Cell and Tissue Research 357(3):707 (2014) PMID 24842051

    Elevated extracellular calcium has been shown to promote the differentiation of osteoblasts. However, the way that calcium affects the osteogenic differentiation of human periodontal ligament stem/progenitor cells (PDLSCs) remains unclear. Our aim has been to investigate the proliferation and os...
  10. The roles of calcium-sensing receptor and calcium channel in osteogenic differentiation of undifferentiated periodontal ligament cells.

    Cell and Tissue Research 357(3):707 (2014) PMID 24842051

    Elevated extracellular calcium has been shown to promote the differentiation of osteoblasts. However, the way that calcium affects the osteogenic differentiation of human periodontal ligament stem/progenitor cells (PDLSCs) remains unclear. Our aim has been to investigate the proliferation and os...
  11. A combination of Wnt and growth factor signaling induces Arl4c expression to form epithelial tubular structures.

    EMBO Journal 33(7):702 (2014) PMID 24562386 PMCID PMC4000088

    Growth factor-dependent epithelial morphological changes and proliferation are essential for the formation of tubular structures, but the underlying molecular mechanisms are poorly understood. Co-stimulation with Wnt3a and epidermal growth factor (Wnt3a/EGF) induced development of tubes consisti...
  12. A combination of Wnt and growth factor signaling induces Arl4c expression to form epithelial tubular structures.

    EMBO Journal 33(7):702 (2014) PMID 24562386 PMCID PMC4000088

    Growth factor-dependent epithelial morphological changes and proliferation are essential for the formation of tubular structures, but the underlying molecular mechanisms are poorly understood. Co-stimulation with Wnt3a and epidermal growth factor (Wnt3a/EGF) induced development of tubes consisti...
  13. The potential role of transient receptor potential type A1 as a mechanoreceptor in human periodontal ligament cells.

    European Journal of Oral Sciences 121(6):538 (2013) PMID 24206072

    Transient receptor potential type A1 (TRPA1) is reported to be a Ca(2+) -permeable channel and is activated by cold temperatures and mechanical stimuli in the hair cells and in dorsal root ganglion. Using a DNA microarray, we found that TRPA1 was significantly up-regulated in human periodontal l...
  14. The potential role of transient receptor potential type A1 as a mechanoreceptor in human periodontal ligament cells.

    European Journal of Oral Sciences 121(6):538 (2013) PMID 24206072

    Transient receptor potential type A1 (TRPA1) is reported to be a Ca(2+) -permeable channel and is activated by cold temperatures and mechanical stimuli in the hair cells and in dorsal root ganglion. Using a DNA microarray, we found that TRPA1 was significantly up-regulated in human periodontal l...
  15. Exposure to transforming growth factor-β1 after basic fibroblast growth factor promotes the fibroblastic differentiation of human periodontal ligament stem/progenitor cell lines.

    Cell and Tissue Research 352(2):249 (2013) PMID 23324989

    Basic fibroblast growth factor (bFGF) is a cytokine that promotes the regeneration of the periodontium, the specialized tissues supporting the teeth. bFGF, does not, however, induce the synthesis of smooth muscle actin alpha 2 (ACTA2), type I collagen (COL1), or COL3, which are principal molecul...
  16. Exposure to transforming growth factor-β1 after basic fibroblast growth factor promotes the fibroblastic differentiation of human periodontal ligament stem/progenitor cell lines.

    Cell and Tissue Research 352(2):249 (2013) PMID 23324989

    Basic fibroblast growth factor (bFGF) is a cytokine that promotes the regeneration of the periodontium, the specialized tissues supporting the teeth. bFGF, does not, however, induce the synthesis of smooth muscle actin alpha 2 (ACTA2), type I collagen (COL1), or COL3, which are principal molecul...
  17. Periodontal tissue engineering: defining the triad.

    The International journal of oral & maxillofaci... 28(6):e461 (2013) PMID 24278956

    The idea that somatic stem cells are localized in periodontal ligament (PDL) tissues as PDL stem cells (PDLSCs) responsible for construction and reconstruction of the periodontium has been widely accepted. Many dental scientists have attempted to clarify the identity of these PDLSCs, but the num...
  18. Alternation of extracellular matrix remodeling and apoptosis by activation of the aryl hydrocarbon receptor pathway in human periodontal ligament cells.

    Journal of Cellular Biochemistry 113(10):3093 (2012) PMID 22581694

    It is well known that the aryl hydrocarbon receptor (AhR) is involved in the toxicity of halogenated aromatic hydrocarbons (HAH) and polycyclic aromatic hydrocarbons (PAH). Recent experiments have shown the induction of impaired tooth and hard-tissue formation by AhR pathway activation, however,...
  19. Alternation of extracellular matrix remodeling and apoptosis by activation of the aryl hydrocarbon receptor pathway in human periodontal ligament cells.

    Journal of Cellular Biochemistry 113(10):3093 (2012) PMID 22581694

    It is well known that the aryl hydrocarbon receptor (AhR) is involved in the toxicity of halogenated aromatic hydrocarbons (HAH) and polycyclic aromatic hydrocarbons (PAH). Recent experiments have shown the induction of impaired tooth and hard-tissue formation by AhR pathway activation, however,...
  20. Expression and effects of glial cell line-derived neurotrophic factor on periodontal ligament cells.

    Journal of Clinical Periodontology 39(6):556 (2012) PMID 22512503

    To investigate Glial cell line-derived neurotrophic factor (GDNF) expression in normal and wounded rat periodontal ligament (PDL) and the effects of GDNF on human PDL cells (HPDLCs) migration and extracellular matrix expression in HPDLCs. The expression of GDNF and GDNF receptors was examined by...