1. A mutation of the Col2a1 gene (G1170S) alters the transgenic murine phenotype and cartilage matrix homeostasis

    Journal of the Formosan Medical Association 113(11):803 (2014)

    Background/Purpose Genomic studies have revealed that there is a significant association between a point mutation of the human Col2A1 gene (G1170S) and several hip disorders. The purpose of the study was to explore the phenotype and altered cartilage matrix homeostasis of tra...
  2. A mutation of the Col2a1 gene (G1170S) alters the transgenic murine phenotype and cartilage matrix homeostasis.

    Journal of the Formosan Medical Association 113(11):803 (2014) PMID 24168833

    Genomic studies have revealed that there is a significant association between a point mutation of the human Col2A1 gene (G1170S) and several hip disorders. The purpose of the study was to explore the phenotype and altered cartilage matrix homeostasis of transgenic mice carrying this mutated Col2...
  3. A mutation of the Col2a1 gene (G1170S) alters the transgenic murine phenotype and cartilage matrix homeostasis.

    Journal of the Formosan Medical Association 113(11):803 (2014) PMID 24168833

    Genomic studies have revealed that there is a significant association between a point mutation of the human Col2A1 gene (G1170S) and several hip disorders. The purpose of the study was to explore the phenotype and altered cartilage matrix homeostasis of transgenic mice carrying this mutated Col2...
  4. Genetic variants associated with phenytoin-related severe cutaneous adverse reactions.

    JAMA 312(5):525 (2014) PMID 25096692

    The antiepileptic drug phenytoin can cause cutaneous adverse reactions, ranging from maculopapular exanthema to severe cutaneous adverse reactions, which include drug reactions with eosinophilia and systemic symptoms, Stevens-Johnson syndrome, and toxic epidermal necrolysis. The pharmacogenomic ...
  5. Genetic variants associated with phenytoin-related severe cutaneous adverse reactions.

    JAMA 312(5):525 (2014) PMID 25096692

    The antiepileptic drug phenytoin can cause cutaneous adverse reactions, ranging from maculopapular exanthema to severe cutaneous adverse reactions, which include drug reactions with eosinophilia and systemic symptoms, Stevens-Johnson syndrome, and toxic epidermal necrolysis. The pharmacogenomic ...
  6. High-throughput detection of common sequence variations of Fabry disease in Taiwan using DNA mass spectrometry

    Molecular Genetics and Metabolism 111(4):507 (2014)

    Background In view of the therapeutic benefits resulting from early intervention for Fabry disease, our team has implemented an enzyme-based newborn screening in Taiwan since 2008. However, we found that most heterozygous females cannot be detected. To improve the screening e...
  7. High-throughput detection of common sequence variations of Fabry disease in Taiwan using DNA mass spectrometry.

    Molecular Genetics and Metabolism 111(4):507 (2014) PMID 24613481

    In view of the therapeutic benefits resulting from early intervention for Fabry disease, our team has implemented an enzyme-based newborn screening in Taiwan since 2008. However, we found that most heterozygous females cannot be detected. To improve the screening efficiency, a more effective met...
  8. SitA contributes to the virulence ofKlebsiella pneumoniaein a mouse infection model

    Microbes and Infection 16(2):161 (2014)

    Klebsiella pneumoniae is an opportunistic pathogen, which causes a wide range of nosocomial infections. Recently, antibiotic resistance makes K. pneumoniae infection difficult to deal with. Investigation on virulence determinants of K. pneumoniae can provide more information about path...
  9. SitA contributes to the virulence of Klebsiella pneumoniae in a mouse infection model.

    Microbes and Infection 16(2):161 (2014) PMID 24211873

    Klebsiella pneumoniae is an opportunistic pathogen, which causes a wide range of nosocomial infections. Recently, antibiotic resistance makes K. pneumoniae infection difficult to deal with. Investigation on virulence determinants of K. pneumoniae can provide more information about pathogenesis a...
  10. Capsule deletion via a λ-Red knockout system perturbs biofilm formation and fimbriae expression in Klebsiella pneumoniae MGH 78578.

    BMC Research Notes 7:13 (2014) PMID 24398052 PMCID PMC3892127

    Klebsiella pneumoniae is a leading cause of hospital-acquired urinary tract infections and pneumonia worldwide, and is responsible for many cases of pyogenic liver abscess among diabetic patients in Asia. A defining characteristic of this pathogen is the presence of a thick, exterior capsule tha...
  11. Complete sequences of two plasmids in a blaNDM-1-positive Klebsiella oxytoca isolate from Taiwan.

    Antimicrobial Agents and Chemotherapy 57(8):4072 (2013) PMID 23752513 PMCID PMC3719732

    Genetic determinants of a bla(NDM-1)-positive, multidrug-resistant bacterial isolate that caused active infection was investigated by DNA sequencing. Two plasmids, pKOX_NDM1 and pKOX-R1, were identified for the Klebsiella oxytoca strain E718. Sequence annotation revealed a bla(NDM-1) gene in pKO...
  12. MCP-1 as an effector of IL-31 signaling in familial primary cutaneous amyloidosis.

    Journal of Investigative Dermatology 133(5):1375 (2013) PMID 23303452

  13. ALPK1 genetic regulation and risk in relation to gout.

    International Journal of Epidemiology 42(2):466 (2013) PMID 23569188 PMCID PMC3695596

    The present study investigated whether single nucleotide polymorphisms (SNPs) in the alpha-protein kinase 1 (ALPK1) gene are associated with gout in aboriginal and Han Chinese Taiwanese. A total of 1351 aborigines from the community (511 cases and 840 controls) and 511 Han people from hospital (...
  14. Identification of MCP-1 as a Key Effector of IL-31 Signaling in Familial Primary Cutaneous Amyloidosis

    Journal of Dermatological Science 69(2):e54 (2013)

  15. Decoding the disease-associated proteins encoded in the human chromosome 4.

    Journal of Proteome Research 12(1):33 (2013) PMID 23256888

    Chromosome 4 is the fourth largest chromosome, containing approximately 191 megabases (~6.4% of the human genome) with 757 protein-coding genes. A number of marker genes for many diseases have been found in this chromosome, including genetic diseases (e.g., hepatocellular carcinoma) and biomedic...
  16. Copy Number Change of the NDM-1 sequence in a multidrug-resistant Klebsiella pneumoniae clinical isolate.

    PLoS ONE 8(4):e62774 (2013) PMID 23658651 PMCID PMC3639163

    The genetic features of the antimicrobial resistance of a multidrug resistant Klebsiella pneumoniae strain harboring bla NDM-1 were investigated to increase our understanding of the evolution of NDM-1. The strain, KPX, came from a Taiwanese patient with a hospitalization history in New Delhi. Co...
  17. Generation and analysis of the expressed sequence tags from the mycelium of Ganoderma lucidum.

    PLoS ONE 8(5):e61127 (2013) PMID 23658685 PMCID PMC3642047

    Ganoderma lucidum (G. lucidum) is a medicinal mushroom renowned in East Asia for its potential biological effects. To enable a systematic exploration of the genes associated with the various phenotypes of the fungus, the genome consortium of G. lucidum has carried out an expressed sequence tag (...
  18. Complete genome sequence of Klebsiella oxytoca E718, a New Delhi metallo-β-lactamase-1-producing nosocomial strain.

    Journal of Bacteriology 194(19):5454 (2012) PMID 22965083 PMCID PMC3457199

    We report the complete genome sequence of Klebsiella oxytoca E718, a New Delhi metallo-β-lactamase-1 (NDM-1)-producing strain isolated from a renal transplant patient. The genome contains a 6,097,032-bp chromosome and two multidrug resistance plasmids with sizes of 324,906 bp and 110,781 bp.
  19. A persistent level of Cisd2 extends healthy lifespan and delays aging in mice.

    Human Molecular Genetics 21(18):3956 (2012) PMID 22661501

    The CISD2 gene, which is an evolutionarily conserved novel gene, encodes a transmembrane protein primarily associated with the mitochondrial outer membrane. Significantly, the CISD2 gene is located within the candidate region on chromosome 4q where a genetic component for human longevity has bee...
  20. Complete genome sequence of Staphylococcus aureus M013, a pvl-positive, ST59-SCCmec type V strain isolated in Taiwan.

    Journal of Bacteriology 194(5):1256 (2012) PMID 22328755 PMCID PMC3294775

    We report the complete genome sequence of M013, a representative strain of a pvl-positive, sequence type 59-staphylococcal cassette chromosome mec type V (ST59-SCCmec type V) community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) clone in Taiwan. Comparison of M013 with the g...