1. Ribosome Excursions during mRNA Translocation Mediate Broad Branching of Frameshift Pathways

    Cell 160(5):870 (2015)

    Programmed ribosomal frameshifting produces alternative proteins from a single transcript. −1 frameshifting occurs on Escherichia coli’s dnaX mRNA containing a slippery sequence AAAAAAG and peripheral mRNA structural barriers. Here, we reveal hidden aspects of the frameshifting process...
  2. Ribosome Excursions during mRNA Translocation Mediate Broad Branching of Frameshift Pathways.

    Cell 160(5):870 (2015) PMID 25703095 PMCID PMC4344849

    Programmed ribosomal frameshifting produces alternative proteins from a single transcript. -1 frameshifting occurs on Escherichia coli's dnaX mRNA containing a slippery sequence AAAAAAG and peripheral mRNA structural barriers. Here, we reveal hidden aspects of the frameshifting process, includin...
  3. Ribosome Excursions during mRNA Translocation Mediate Broad Branching of Frameshift Pathways.

    Cell 160(5):870 (2015) PMID 25703095 PMCID PMC4344849

    Programmed ribosomal frameshifting produces alternative proteins from a single transcript. -1 frameshifting occurs on Escherichia coli's dnaX mRNA containing a slippery sequence AAAAAAG and peripheral mRNA structural barriers. Here, we reveal hidden aspects of the frameshifting process, includin...
  4. Ribosome Excursions during mRNA Translocation Mediate Broad Branching of Frameshift Pathways.

    Cell 160(5):870 (2015) PMID 25703095

    Programmed ribosomal frameshifting produces alternative proteins from a single transcript. -1 frameshifting occurs on Escherichia coli's dnaX mRNA containing a slippery sequence AAAAAAG and peripheral mRNA structural barriers. Here, we reveal hidden aspects of the frameshifting process, includin...
  5. Deciphering Ribosomal Frameshifting Dynamics

    Biophysical Journal 106(2):239a (2014)

  6. Direct measurement of the mechanical work during translocation by the ribosome.

    eLife 3:e03406 (2014) PMID 25114092 PMCID PMC4126342

    A detailed understanding of tRNA/mRNA translocation requires measurement of the forces generated by the ribosome during this movement. Such measurements have so far remained elusive and, thus, little is known about the relation between force and translocation and how this reflects on its mechani...
  7. Direct measurement of the mechanical work during translocation by the ribosome.

    eLife 3:e03406 (2014) PMID 25114092 PMCID PMC4126342

    A detailed understanding of tRNA/mRNA translocation requires measurement of the forces generated by the ribosome during this movement. Such measurements have so far remained elusive and, thus, little is known about the relation between force and translocation and how this reflects on its mechani...
  8. Direct measurement of the mechanical work during translocation by the ribosome.

    eLife 3:e03406 (2014) PMID 25114092 PMCID PMC4126342

    A detailed understanding of tRNA/mRNA translocation requires measurement of the forces generated by the ribosome during this movement. Such measurements have so far remained elusive and, thus, little is known about the relation between force and translocation and how this reflects on its mechani...
  9. Frameshifting dynamics.

    Biopolymers 99(12):1147 (2013) PMID 23722586 PMCID PMC4011568

    Translation of messenger RNA by a ribosome occurs three nucleotides at a time from start signal to stop. However, a frameshift means that some nucleotides are read twice or some are skipped, and the following sequence of amino acids is completely different from the sequence in the original frame...
  10. Frameshifting dynamics.

    Biopolymers 99(12):1147 (2013) PMID 23722586 PMCID PMC4011568

    Translation of messenger RNA by a ribosome occurs three nucleotides at a time from start signal to stop. However, a frameshift means that some nucleotides are read twice or some are skipped, and the following sequence of amino acids is completely different from the sequence in the original frame...
  11. Deciphering Ribosomal Frameshifting Dynamics

    Biophysical Journal 102(3):68a (2012)

  12. Deciphering Ribosomal Frameshifting Dynamics

    Biophysical Journal 102(3):68a (2012)

  13. Mode specificity in reactions of Cl with CH2 stretch-excited CH2D2(v1, v6 = 1).

    Journal of Physical Chemistry A: Molecules, Spe... 113(52):14270 (2009) PMID 19480395

    We report on a reactive scattering experiment of chlorine atom (Cl) with mode-selected dideutero-methane (CH(2)D(2)) using a pulsed crossed beam approach with a time-sliced velocity-map imaging detection of the methyl radical products. Reactivity with one-quantum excitation of CH(2)D(2) in eithe...
  14. Mode specificity in reactions of Cl with CH2 stretch-excited CH2D2(v1, v6 = 1).

    Journal of Physical Chemistry A: Molecules, Spe... 113(52):14270 (2009) PMID 19480395

    We report on a reactive scattering experiment of chlorine atom (Cl) with mode-selected dideutero-methane (CH(2)D(2)) using a pulsed crossed beam approach with a time-sliced velocity-map imaging detection of the methyl radical products. Reactivity with one-quantum excitation of CH(2)D(2) in eithe...
  15. Tracking the energy flow along the reaction path.

    PNAS 105(35):12667 (2008) PMID 18664573 PMCID PMC2529050

    We report a comprehensive study of the quantum-state correlation property of product pairs from reactions of chlorine atoms with both the ground-state and the CH stretch-excited CHD(3). In light of available ab initio theoretical results, this set of experimental data provides a conceptual frame...
  16. Tracking the energy flow along the reaction path.

    PNAS 105(35):12667 (2008) PMID 18664573 PMCID PMC2529050

    We report a comprehensive study of the quantum-state correlation property of product pairs from reactions of chlorine atoms with both the ground-state and the CH stretch-excited CHD(3). In light of available ab initio theoretical results, this set of experimental data provides a conceptual frame...
  17. A simple yet effective multipass reflector for vibrational excitation in molecular beams.

    Review of Scientific Instrument 79(3):033105 (2008) PMID 18376995

    The fraction of molecules that can be vibrationally excited is often the limiting factor in many infrared laser excitation experiments, in particular, when using weak absorption bands. Reported here is a simple multipass reflector designed to overcome that obstacle. Its enhancement in pumping ef...
  18. A simple yet effective multipass reflector for vibrational excitation in molecular beams.

    Review of Scientific Instrument 79(3):033105 (2008) PMID 18376995

    The fraction of molecules that can be vibrationally excited is often the limiting factor in many infrared laser excitation experiments, in particular, when using weak absorption bands. Reported here is a simple multipass reflector designed to overcome that obstacle. Its enhancement in pumping ef...
  19. Unraveling multicomponent images by extended cross correlation analysis.

    Journal of Physical Chemistry A: Molecules, Spe... 111(38):9263 (2007) PMID 17636971

    In the course of studying the reaction dynamics of F + CH(2)D(2) --> HF + CHD(2), several small features in the (2+1) REMPI spectra of the CHD(2) product were observed. Using the technique of imaging spectroscopy, those new features were identified and assigned to the 2(1)(1), 3(1)(1), and 5(1)(...
  20. Unraveling multicomponent images by extended cross correlation analysis.

    Journal of Physical Chemistry A: Molecules, Spe... 111(38):9263 (2007) PMID 17636971

    In the course of studying the reaction dynamics of F + CH(2)D(2) --> HF + CHD(2), several small features in the (2+1) REMPI spectra of the CHD(2) product were observed. Using the technique of imaging spectroscopy, those new features were identified and assigned to the 2(1)(1), 3(1)(1), and 5(1)(...