1. Shielding artificially increases the attenuation of water: study of CT gradient attenuation induced by shielding (CT GAINS).

    Academic Radiology 20(2):231 (2013) PMID 22981602

    Quantitatively analyze the computed tomography (CT) attenuation effects caused by bismuth shields, which are used to reduce superficial organ dose. The solid water uniformity section of the American College of Radiology CT phantom was scanned with a modified chest CT protocol. Scans were perform...
  2. A comprehensive approach to CT radiation dose reduction: one institution's experience.

    American Journal of Roentgenology 197(4):935 (2011) PMID 21940582

    The purpose of this article is to review the process of creating and implementing a comprehensive plan to reduce diagnostic radiation exposure at our institution. This process, which was initiated by forming a radiation dose reduction committee, addressed several different issues to improve pati...
  3. Out-of-hospital hypertonic resuscitation after traumatic hypovolemic shock: a randomized, placebo controlled trial.

    Annals of Surgery 253(3):431 (2011) PMID 21178763 PMCID PMC3232054

    To determine whether out-of-hospital administration of hypertonic fluids would improve survival after severe injury with hemorrhagic shock. Hypertonic fluids have potential benefit in the resuscitation of severely injured patients because of rapid restoration of tissue perfusion, with a smaller ...
  4. Out-of-hospital hypertonic resuscitation following severe traumatic brain injury: a randomized controlled trial.

    JAMA 304(13):1455 (2010) PMID 20924011 PMCID PMC3015143

    Hypertonic fluids restore cerebral perfusion with reduced cerebral edema and modulate inflammatory response to reduce subsequent neuronal injury and thus have potential benefit in resuscitation of patients with traumatic brain injury (TBI). To determine whether out-of-hospital administration of ...
  5. A critical assessment of the out-of-hospital trauma triage guidelines for physiologic abnormality.

    Journal of Trauma 68(2):452 (2010) PMID 20154558 PMCID PMC3785297

    It remains unclear whether the American College of Surgeons Committee on Trauma (ACSCOT) "step 1" field physiologic criteria could be further restricted without substantially sacrificing sensitivity. We assessed whether more restrictive physiologic criteria would improve the specificity of this ...
  6. The availability and use of out-of-hospital physiologic information to identify high-risk injured children in a multisite, population-based cohort.

    Prehospital Emergency Care 13(4):420 (2009) PMID 19731152 PMCID PMC3008574

    The validity of using adult physiologic criteria to triage injured children in the out-of-hospital setting remains unproven. Among children meeting adult field physiologic criteria, we assessed the availability of physiologic information, the incidence of death or prolonged hospitalization, and ...
  7. Resuscitation Outcomes Consortium (ROC) PRIMED cardiac arrest trial methods:Part 1: Rationale and methodology for the impedance threshold device (ITD) protocol

    Resuscitation 78(2):179 (2008) PMID 18487005 PMCID PMC3797446

    Aim The primary aim of this study is to compare survival to hospital discharge with a modified Rankin score (MRS) ≤ 3 between standard cardiopulmonary resuscitation (CPR) plus an active impedance threshold device (ITD) versus standard CPR plus a sham ITD in patients with ou...
  8. Resuscitation Outcomes Consortium (ROC) PRIMED cardiac arrest trial methods:Part 1: Rationale and methodology for the impedance threshold device (ITD) protocol

    Resuscitation 78(2):179 (2008) PMID 18487005 PMCID PMC3797446

    Aim The primary aim of this study is to compare survival to hospital discharge with a modified Rankin score (MRS) ≤ 3 between standard cardiopulmonary resuscitation (CPR) plus an active impedance threshold device (ITD) versus standard CPR plus a sham ITD in patients with ou...
  9. Chromosomal instability in ulcerative colitis is related to telomere shortening.

    Nature Genetics 32(2):280 (2002) PMID 12355086

    Ulcerative colitis, a chronic inflammatory disease of the colon, is associated with a high risk of colorectal carcinoma that is thought to develop through genomic instability. We considered that the rapid cell turnover and oxidative injury observed in ulcerative colitis might accelerate telomere...
  10. The importance of the normality assumption in large public health data sets.

    Public Health 23:151 (2002) PMID 11910059

    It is widely but incorrectly believed that the t-test and linear regression are valid only for Normally distributed outcomes. The t-test and linear regression compare the mean of an outcome variable for different subjects. While these are valid even in very small samples if the outcome variable ...
  11. Anthropometric measures and risk of death in children with end-stage renal disease

    American Journal of Kidney Diseases 36(4):811 (2000)

    We evaluated the association between anthropometric measurements and death among pediatric patients with end-stage renal disease (ESRD) using data from the Pediatric Growth and Development Special Study (PGDSS) from the US Renal Data System. Height, growth velocity, and body mass index...
  12. Screening plasma aluminum levels in relation to aluminum bone disease among asymptomatic dialysis patients

    American Journal of Kidney Diseases 34(4):688 (1999)

    Aluminum accumulation in plasma and tissues is a well-described complication among persons undergoing peritoneal dialysis or hemodialysis. Excess bone aluminum is associated with low bone formation rates and increased risk for fractures. Current recommendations for care of patients with end...
  13. Cytogenetics of 158 patients with regional or disseminated melanoma Subset analysis of near-diploid and simple karyotypes

    Cancer Genetics and Cytogenetics 83(2):93 (1995) PMID 7553595

    We report on the cytogenetic analyses of 158 cases of metastatic malignant melanoma, comprised of 63 cases with regional disease (RD) and 95 cases with distant (metastatic) disease (DD). Clonal structural abnormalities were identified in 126 (80%) cases and were significantly increased (< 0...
  14. Increased neutrophil elastase release in unstable angina pectoris and acute myocardial infarction

    Journal of the American College of Cardiology 15(7):1559 (1990)

    Neutrophils, a source of proteolytic enzymes and oxygen free radicals, have been shown to participate in animal models of myocardial ischemic injury. To characterize neutrophil activation in human ischemic heart disease, a specific neutrophil elastase-derived fibrinopeptide in plasma was me...