1. Nuclear-Receptor-Mediated Telomere Insertion Leads to Genome Instability in ALT Cancers

    Cell 160(5):913 (2015)

    The breakage-fusion-bridge cycle is a classical mechanism of telomere-driven genome instability in which dysfunctional telomeres are fused to other chromosomal extremities, creating dicentric chromosomes that eventually break at mitosis. Here, we uncover a distinct pathway of telomere-...
  2. Nuclear-Receptor-Mediated Telomere Insertion Leads to Genome Instability in ALT Cancers

    Cell 160(5):913 (2015) PMID 25723166

    The breakage-fusion-bridge cycle is a classical mechanism of telomere-driven genome instability in which dysfunctional telomeres are fused to other chromosomal extremities, creating dicentric chromosomes that eventually break at mitosis. Here, we uncover a distinct pathway of telomere-...
  3. Nuclear-Receptor-Mediated Telomere Insertion Leads to Genome Instability in ALT Cancers.

    Cell 160(5):913 (2015) PMID 25723166

    The breakage-fusion-bridge cycle is a classical mechanism of telomere-driven genome instability in which dysfunctional telomeres are fused to other chromosomal extremities, creating dicentric chromosomes that eventually break at mitosis. Here, we uncover a distinct pathway of telomere-driven gen...
  4. Rif1 maintains telomere length homeostasis of ESCs by mediating heterochromatin silencing.

    Developmental Cell 29(1):7 (2014) PMID 24735877

    Telomere length homeostasis is essential for genomic stability and unlimited self-renewal of embryonic stem cells (ESCs). We show that telomere-associated protein Rif1 is required to maintain telomere length homeostasis by negatively regulating Zscan4 expression, a critical factor for telomere e...
  5. Alternative lengthening of telomeres: recurrent cytogenetic aberrations and chromosome stability under extreme telomere dysfunction.

    Neoplasia 15(11):1301 (2013) PMID 24339742 PMCID PMC3858894

    Human tumors using the alternative lengthening of telomeres (ALT) exert high rates of telomere dysfunction. Numerical chromosomal aberrations are very frequent, and structural rearrangements are widely scattered among the genome. This challenging context allows the study of telomere dysfunction-...
  6. Alternative Lengthening of Telomeres: Recurrent Cytogenetic Aberrations and Chromosome Stability under Extreme Telomere Dysfunction

    Neoplasia 15(11):1301 (2013)

    Human tumors using the alternative lengthening of telomeres (ALT) exert high rates of telomere dysfunction. Numerical chromosomal aberrations are very frequent, and structural rearrangements are widely scattered among the genome. This challenging context allows the study of telomere dy...
    PDF not found
  7. Alternative Lengthening of Telomeres: Recurrent Cytogenetic Aberrations and Chromosome Stability under Extreme Telomere Dysfunction

    Neoplasia 15(11):1301 (2013)

    Human tumors using the alternative lengthening of telomeres (ALT) exert high rates of telomere dysfunction. Numerical chromosomal aberrations are very frequent, and structural rearrangements are widely scattered among the genome. This challenging context allows the study of telomere dy...
    PDF not found
  8. Alternative lengthening of telomeres: recurrent cytogenetic aberrations and chromosome stability under extreme telomere dysfunction.

    Neoplasia 15(11):1301 (2013) PMID 24339742 PMCID PMC3858894

    Human tumors using the alternative lengthening of telomeres (ALT) exert high rates of telomere dysfunction. Numerical chromosomal aberrations are very frequent, and structural rearrangements are widely scattered among the genome. This challenging context allows the study of telomere dysfunction-...
  9. Molecular and cytogenetic changes in multi-drug resistant cancer cells and their influence on new compounds testing.

    Cancer Chemotherapy and Pharmacology 72(3):683 (2013) PMID 23934261

    Multi-drug resistance (MDR) is a major obstacle to successful cancer treatment. Therefore, in vitro models are necessary for the investigation of the phenotypic changes provoked by cytotoxic agents and more importantly for preclinical testing of new anticancer drugs. We analyzed chromosomal, num...
  10. Molecular and cytogenetic changes in multi-drug resistant cancer cells and their influence on new compounds testing.

    Cancer Chemotherapy and Pharmacology 72(3):683 (2013) PMID 23934261

    Multi-drug resistance (MDR) is a major obstacle to successful cancer treatment. Therefore, in vitro models are necessary for the investigation of the phenotypic changes provoked by cytotoxic agents and more importantly for preclinical testing of new anticancer drugs. We analyzed chromosomal, num...
  11. Rif1Maintains Telomere Length Homeostasis of ES Cells by Mediating Heterochromatin Silencing

    Developmental Cell 29(1) (2013) PMID 24735877

    Telomere length homeostasis is essential for genomic stability and unlimited self-renewal of embryonic stem (ES) cells. We show that telomere associated protein Rif1 is required to maintain telomere length homeostasis by negatively regulating Zscan4 expression, a critical factor for te...
  12. Rif1Maintains Telomere Length Homeostasis of ES Cells by Mediating Heterochromatin Silencing

    Developmental Cell (2013)

    Telomere length homeostasis is essential for genomic stability and unlimited self-renewal of embryonic stem (ES) cells. We show that telomere associated protein Rif1 is required to maintain telomere length homeostasis by negatively regulating Zscan4 expression, a critical factor for te...
  13. The Roles of Telomerase in the Generation of Polyploidy during Neoplastic Cell Growth

    Neoplasia 15(2):156,IN11 (2013)

    Polyploidy contributes to extensive intratumor genomic heterogeneity that characterizes advanced malignancies and is thought to limit the efficiency of current cancer therapies. It has been shown that telomere deprotection in p53-deficient mouse embryonic fibroblasts leads to high rate...
    PDF not found
  14. The Roles of Telomerase in the Generation of Polyploidy during Neoplastic Cell Growth

    Neoplasia 15(2):156,IN11 (2013)

    Polyploidy contributes to extensive intratumor genomic heterogeneity that characterizes advanced malignancies and is thought to limit the efficiency of current cancer therapies. It has been shown that telomere deprotection in p53-deficient mouse embryonic fibroblasts leads to high rate...
    PDF not found
  15. The roles of telomerase in the generation of polyploidy during neoplastic cell growth.

    Neoplasia 15(2):156 (2013) PMID 23441130 PMCID PMC3579318

    Polyploidy contributes to extensive intratumor genomic heterogeneity that characterizes advanced malignancies and is thought to limit the efficiency of current cancer therapies. It has been shown that telomere deprotection in p53-deficient mouse embryonic fibroblasts leads to high rates of polyp...
  16. The roles of telomerase in the generation of polyploidy during neoplastic cell growth.

    Neoplasia 15(2):156 (2013) PMID 23441130 PMCID PMC3579318

    Polyploidy contributes to extensive intratumor genomic heterogeneity that characterizes advanced malignancies and is thought to limit the efficiency of current cancer therapies. It has been shown that telomere deprotection in p53-deficient mouse embryonic fibroblasts leads to high rates of polyp...
  17. Telomere reprogramming and maintenance in porcine iPS cells.

    PLoS ONE 8(9):e74202 (2013) PMID 24098638 PMCID PMC3787036

    Telomere reprogramming and silencing of exogenous genes have been demonstrated in mouse and human induced pluripotent stem cells (iPS cells). Pigs have the potential to provide xenotransplant for humans, and to model and test human diseases. We investigated the telomere length and maintenance in...
  18. Telomere reprogramming and maintenance in porcine iPS cells.

    PLoS ONE 8(9):e74202 (2013) PMID 24098638 PMCID PMC3787036

    Telomere reprogramming and silencing of exogenous genes have been demonstrated in mouse and human induced pluripotent stem cells (iPS cells). Pigs have the potential to provide xenotransplant for humans, and to model and test human diseases. We investigated the telomere length and maintenance in...
  19. Conservation and characterization of unique porcine interstitial telomeric sequences.

    SCIENCE CHINA Life Science 55(12):1029 (2012) PMID 23233217

    Telomeres are composed of TTAGGG repeats and located at the ends of chromosomes. Telomeres protect chromosomes from instability in mammals, including mice and humans. Repetitive TTAGGG sequences are also found at intrachromosomal sites, where they are named as interstitial telomeric sequences (I...
  20. Conservation and characterization of unique porcine interstitial telomeric sequences.

    SCIENCE CHINA Life Science 55(12):1029 (2012) PMID 23233217

    Telomeres are composed of TTAGGG repeats and located at the ends of chromosomes. Telomeres protect chromosomes from instability in mammals, including mice and humans. Repetitive TTAGGG sequences are also found at intrachromosomal sites, where they are named as interstitial telomeric sequences (I...