Serum Amyloid A Induces Inflammation, Proliferation and Cell Death in Activated Hepatic Stellate Cells.
PLoS ONE 11(3):e0150893 (2016)
Serum amyloid A (SAA) is an evolutionary highly conserved acute phase protein that is predominantly secreted by hepatocytes. However, its role in liver injury and fibrogenesis has not been elucidated so far. In this study, we determined the effects of SAA on hepatic stellate cells (HSCs), the ma...
Are we ready for early discharge of patients with mild non-alcoholic acute interstitial pancreatitis?
Pancreatology 16(3):322 (2016)
Extra-endoscopic mechanical lithotripsy of an impacted gallstone passing in the duodenum through a cholecystoduodenal fistula.
Digestive and Liver Disease 47(11):992 (2015)
Small bowel diverticulitis with severe anemia and abdominal pain.
World journal of clinical cases 3(5):462 (2015)
The current case report is related to a male patient with diabetes, obesity [body mass index (BMI) 33], hypertension and recurrence of anemia associated to melena and deep asthenia. M.P., a 60-year-old obese individual, was referred to our department by the primary care unit (PCU) of our hospita...
PDX-1 mRNA expression in endoscopic ultrasound-guided fine needle cytoaspirate: perspectives in the diagnosis of pancreatic cancer.
Digestive and Liver Disease 47(2):138 (2015)
Endoscopic ultrasound-guided fine needle aspiration is routinely used in the diagnostic work up of pancreatic cancer but has a low sensitivity. Studies showed that Pancreatic Duodenal Homeobox-1 (PDX-1) is expressed in pancreatic cancer, which is associated with a worse prognosis. We aimed to ve...
Activation of the developmental pathway neurogenin-3/microRNA-7a regulates cholangiocyte proliferation in response to injury.
Hepatology 60(4):1324 (2014)
The activation of the biliary stem-cell signaling pathway hairy and enhancer of split 1/pancreatic duodenal homeobox-1 (Hes-1/PDX-1) in mature cholangiocytes determines cell proliferation. Neurogenin-3 (Ngn-3) is required for pancreas development and ductal cell neogenesis. PDX-1-dependent activ...
VEGF and VEGFR genotyping in the prediction of clinical outcome for HCC patients receiving sorafenib: the ALICE-1 study.
International Journal of Cancer 135(5):1247 (2014)
Although new treatment modalities changed the global approach to hepatocellular carcinoma (HCC), this disease still represents a medical challenge. Currently, the therapeutic stronghold is sorafenib, a tyrosine kinase inhibitor (TKI) directed against the vascular endothelial growth factor (VEGF)...
Role of NADPH oxidases in liver fibrosis.
Antioxidants and Redox Signaling 20(17):2854 (2014)
Hepatic fibrosis is the common pathophysiologic process resulting from chronic liver injury, characterized by the accumulation of an excessive extracellular matrix. Multiple lines of evidence indicate that oxidative stress plays a pivotal role in the pathogenesis of liver fibrosis. Nicotinamide ...
Dysbiosis contributes to fibrogenesis in the course of chronic liver injury in mice.
Hepatology 59(5):1738 (2014)
Nonalcoholic fatty liver disease (NAFLD) may lead to hepatic fibrosis. Dietary habits affect gut microbiota composition, whereas endotoxins produced by Gram-negative bacteria stimulate hepatic fibrogenesis. However, the mechanisms of action and the potential effect of microbiota in the liver are...
HCC development is associated to peripheral insulin resistance in a mouse model of NASH.
PLoS ONE 9(5):e97136 (2014)
NAFLD is the most common liver disease worldwide but it is the potential evolution to NASH and eventually to hepatocellular carcinoma (HCC), even in the absence of cirrhosis, that makes NAFLD of such clinical importance.
we aimed to create a mouse model reproducing the pathological spectrum of N...
GIV/Girdin is a central hub for profibrogenic signalling networks during liver fibrosis.
Nature Communications 5:4451 (2014)
Progressive liver fibrosis is characterized by the deposition of collagen by activated hepatic stellate cells (HSCs). Activation of HSCs is a multiple receptor-driven process in which profibrotic signals are enhanced and antifibrotic pathways are suppressed. Here we report the discovery of a sig...
The role of LDH serum levels in predicting global outcome in HCC patients treated with sorafenib: implications for clinical management.
BMC Cancer 14:110 (2014)
In many tumour types serumlactate dehydrogenase (LDH) levels proved to represent an indirect marker of tumour hypoxia, neo-angiogenesis and worse prognosis. As we previously reported LDH is an important predictive factor in hepatocellular carcinoma (HCC) patients undergoing transarterial chemoem...
Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice.
Hepatology 58(4):1461 (2013)
Although it is well established that hepatic macrophages play a crucial role in the development of liver fibrosis, the underlying mechanisms remain largely elusive. Moreover, it is not known whether other mononuclear phagocytes such as dendritic cells (DCs) contribute to hepatic stellate cell (H...
Semaphorin 7A contributes to TGF-β-mediated liver fibrogenesis.
The American Journal of Pathology 183(3):820 (2013)
Semaphorin7A (SEMA7A) is a membrane-anchored protein involved in immune and inflammatory responses, exerting an effect on pulmonary fibrosis. Thus, we aimed to investigate the role of SEMA7A in hepatic fibrosis. Liver injury was induced in vivo by carbon tetrachloride i.p. injection or bile duct...
New insights in hepatocellular carcinoma: from bench to bedside.
Annals of translational medicine 1(2):15 (2013)
Hepatocarcinogenesis is a multistep process involving different genetic alterations that ultimately lead to malignant transformation of the hepatocyte. The liver is one of the main targets for different metastatic foci, but it represents an important and frequent locus of degeneration in the cou...
Liver carcinogenesis: Rodent models of hepatocarcinoma and cholangiocarcinoma
Digestive and Liver Disease 45(6):450 (2013)
Hepatocellular carcinoma and cholangiocarcinoma are primary liver cancers, both represent a growing challenge for clinicians due to their increasing morbidity and mortality.
In the last few years a number of in vivo models of hepatocellular carcinoma and cholangiocarcinoma ha...
198 PDX-1 mRNA Expression in Endoscopic Ultrasound-Guided Fine Needle Cytoaspirate As a New Marker for the Diagnosis of Pancreatic Cancer
Gastrointestinal Endoscopy 77(5):AB135 (2013)
PDX-1/Hes-1 interactions determine cholangiocyte proliferative response to injury in rodents: Possible implications for sclerosing cholangitis
Journal of Hepatology 58(4):750 (2013)
Background & Aims
Cholangiocyte proliferation plays a role in the progression of cholangiopathies, in particular in primary sclerosing cholangitis. The mechanisms regulating cholangiocyte proliferation are still undefined. Pancreatic Duodenal Homeobox protein 1 (PDX-1) is exp...
From NAFLD to NASH and HCC: pathogenetic mechanisms and therapeutic insights.
Current Pharmaceutical Design 19(29):5239 (2013)
NAFLD is the most common liver disease worldwide but it is the potential evolution to cirrhosis and hepatocellular carcinoma (HCC) that makes NAFLD of such clinical importance. The current work provides an overview of the main mechanims and potential therapeutical insights involved in NAFLD, NAS...
Endoplasmic Reticulum stress induces hepatic stellate cell apoptosis and contributes to fibrosis resolution.
Liver International 32(10):1574 (2012)
Survival of hepatic stellate cells (HSCs) is a hallmark of liver fibrosis, while the induction of HSC apoptosis may induce recovery. Activated HSC are resistant to many pro-apoptotic stimuli. To this issue, the role of Endoplasmic Reticulum (ER) stress in promoting apoptosis of HSCs and conseque...