1. Immunological memory ≠ protective immunity.

    Experientia. Basel 69(10):1635 (2012) PMID 22481438

    So-called 'immunological memory' is, in my view, a typical example where a field of enquiry, i.e. to understand long-term protection to survive reexposure to infection, has been overtaken by 'l'art pour l'art' of 'basic immunology'. The aim of this critical review is to point out some key differ...
  2. Immunological memory ≠ protective immunity.

    Experientia. Basel 69(10):1635 (2012) PMID 22481438

    So-called 'immunological memory' is, in my view, a typical example where a field of enquiry, i.e. to understand long-term protection to survive reexposure to infection, has been overtaken by 'l'art pour l'art' of 'basic immunology'. The aim of this critical review is to point out some key differ...
  3. A platelet-mediated system for shuttling blood-borne bacteria to CD8α+ dendritic cells depends on glycoprotein GPIb and complement C3.

    Nature Immunology 12(12):1194 (2011) PMID 22037602

    The acquisition of pathogen-derived antigen by dendritic cells (DCs) is a key event in the generation of cytotoxic CD8(+) T cell responses. In mice, the intracellular bacterium Listeria monocytogenes is directed from the blood to splenic CD8α(+) DCs. We report that L. monocytogenes rapidly assoc...
  4. A platelet-mediated system for shuttling blood-borne bacteria to CD8α+ dendritic cells depends on glycoprotein GPIb and complement C3.

    Nature Immunology 12(12):1194 (2011) PMID 22037602

    The acquisition of pathogen-derived antigen by dendritic cells (DCs) is a key event in the generation of cytotoxic CD8(+) T cell responses. In mice, the intracellular bacterium Listeria monocytogenes is directed from the blood to splenic CD8α(+) DCs. We report that L. monocytogenes rapidly assoc...
  5. Tissue macrophages suppress viral replication and prevent severe immunopathology in an interferon-I-dependent manner in mice.

    Hepatology 52(1):25 (2010) PMID 20578253

    The innate immune response plays an essential role in the prevention of early viral dissemination. We used the lymphocytic choriomeningitis virus model system to analyze the role of tissue macrophages/Kupffer cells in this process. Our findings demonstrated that Kupffer cells are essential for t...
  6. Tissue macrophages suppress viral replication and prevent severe immunopathology in an interferon-I-dependent manner in mice.

    Hepatology 52(1):25 (2010) PMID 20578253

    The innate immune response plays an essential role in the prevention of early viral dissemination. We used the lymphocytic choriomeningitis virus model system to analyze the role of tissue macrophages/Kupffer cells in this process. Our findings demonstrated that Kupffer cells are essential for t...
  7. Long-lasting immunity by early infection of maternal-antibody-protected infants.

    European Journal of Immunology 40(1):113 (2010) PMID 19877011

    Newborn higher vertebrates are largely immuno-incompetent and generally survive infections--including poxviruses--by maternal antibody protection. Here, we show that mice survived epidemics as adults only if exposed to lethal orthopoxvirus infections during infancy under the umbrella of maternal...
  8. Long-lasting immunity by early infection of maternal-antibody-protected infants.

    European Journal of Immunology 40(1):113 (2010) PMID 19877011

    Newborn higher vertebrates are largely immuno-incompetent and generally survive infections--including poxviruses--by maternal antibody protection. Here, we show that mice survived epidemics as adults only if exposed to lethal orthopoxvirus infections during infancy under the umbrella of maternal...
  9. Innate immune-induced depletion of bone marrow neutrophils aggravates systemic bacterial infections.

    PNAS 106(17):7107 (2009) PMID 19351895 PMCID PMC2678456

    Neutrophils are the most abundant leukocytes in circulation and provide a primary innate immune defense function against bacterial pathogens before development of a specific immune response. These specialized phagocytes are short lived (12-24 hours) and continuously replenished from bone marrow....
  10. Innate immune-induced depletion of bone marrow neutrophils aggravates systemic bacterial infections.

    PNAS 106(17):7107 (2009) PMID 19351895 PMCID PMC2678456

    Neutrophils are the most abundant leukocytes in circulation and provide a primary innate immune defense function against bacterial pathogens before development of a specific immune response. These specialized phagocytes are short lived (12-24 hours) and continuously replenished from bone marrow....
  11. Recombination of retrotransposon and exogenous RNA virus results in nonretroviral cDNA integration.

    Science 323(5912):393 (2009) PMID 19150848

    Retroviruses have the potential to acquire host cell-derived genetic material during reverse transcription and can integrate into the genomes of larger, more complex DNA viruses. In contrast, RNA viruses were believed not to integrate into the host's genome under any circumstances. We found that...
  12. Recombination of retrotransposon and exogenous RNA virus results in nonretroviral cDNA integration.

    Science 323(5912):393 (2009) PMID 19150848

    Retroviruses have the potential to acquire host cell-derived genetic material during reverse transcription and can integrate into the genomes of larger, more complex DNA viruses. In contrast, RNA viruses were believed not to integrate into the host's genome under any circumstances. We found that...
  13. Polyclonal and specific antibodies mediate protective immunity against enteric helminth infection.

    Cell Host & Microbe 4(4):362 (2008) PMID 18854240

    Anti-helminth immunity involves CD4+ T cells, yet the precise effector mechanisms responsible for parasite killing or expulsion remain elusive. We now report an essential role for antibodies in mediating immunity against the enteric helminth Heligmosomoides polygyrus (Hp), a natural murine paras...
  14. Polyclonal and specific antibodies mediate protective immunity against enteric helminth infection.

    Cell Host & Microbe 4(4):362 (2008) PMID 18854240

    Anti-helminth immunity involves CD4+ T cells, yet the precise effector mechanisms responsible for parasite killing or expulsion remain elusive. We now report an essential role for antibodies in mediating immunity against the enteric helminth Heligmosomoides polygyrus (Hp), a natural murine paras...
  15. Aggravation of viral hepatitis by platelet-derived serotonin.

    Nature Medicine 14(7):756 (2008) PMID 18516052

    More than 500 million people worldwide are persistently infected with hepatitis B virus or hepatitis C virus. Although both viruses are poorly cytopathic, persistence of either virus carries a risk of chronic liver inflammation, potentially resulting in liver steatosis, liver cirrhosis, end-stag...
  16. Aggravation of viral hepatitis by platelet-derived serotonin.

    Nature Medicine 14(7):756 (2008) PMID 18516052

    More than 500 million people worldwide are persistently infected with hepatitis B virus or hepatitis C virus. Although both viruses are poorly cytopathic, persistence of either virus carries a risk of chronic liver inflammation, potentially resulting in liver steatosis, liver cirrhosis, end-stag...
  17. Long-lived virus-reactive memory T cells generated from purified cytokine-secreting T helper type 1 and type 2 effectors.

    Journal of Experimental Medicine 205(1):53 (2008) PMID 18195073 PMCID PMC2234365

    Many vaccination strategies and immune cell therapies aim at increasing the numbers of memory T cells reactive to protective antigens. However, the differentiation lineage and therefore the optimal generation conditions of CD4 memory cells remain controversial. Linear and divergent differentiati...
  18. Long-lived virus-reactive memory T cells generated from purified cytokine-secreting T helper type 1 and type 2 effectors.

    Journal of Experimental Medicine 205(1):53 (2008) PMID 18195073 PMCID PMC2234365

    Many vaccination strategies and immune cell therapies aim at increasing the numbers of memory T cells reactive to protective antigens. However, the differentiation lineage and therefore the optimal generation conditions of CD4 memory cells remain controversial. Linear and divergent differentiati...
  19. Long-term maternal imprinting of the specific B cell repertoire by maternal antibodies.

    European Journal of Immunology 38(1):90 (2008) PMID 18081043

    Maternal antibodies protect newborns whilst they are immunologically immature. This study shows that maternal antibodies can also shape the B cell repertoire of the offspring long after the maternal antibodies themselves become undetectable. V(H)DJ(H) gene-targeted (VI10) mice expressing a heavy...
  20. Long-term maternal imprinting of the specific B cell repertoire by maternal antibodies.

    European Journal of Immunology 38(1):90 (2008) PMID 18081043

    Maternal antibodies protect newborns whilst they are immunologically immature. This study shows that maternal antibodies can also shape the B cell repertoire of the offspring long after the maternal antibodies themselves become undetectable. V(H)DJ(H) gene-targeted (VI10) mice expressing a heavy...