1. The LGI1-ADAM22 protein complex directs synapse maturation through regulation of PSD-95 function.

    PNAS 112(30):E4129 (2015) PMID 26178195

    Synapse development is coordinated by a number of transmembrane and secreted proteins that come together to form synaptic organizing complexes. Whereas a variety of synaptogenic proteins have been characterized, much less is understood about the molecular networks that support the maintenance an...
  2. Is Aspartate an Excitatory Neurotransmitter?

    Journal of Neuroscience 35(28):10168 (2015) PMID 26180193 PMCID PMC4502257

    Recent evidence has resurrected the idea that the amino acid aspartate, a selective NMDA receptor agonist, is a neurotransmitter. Using a mouse that lacks the glutamate-selective vesicular transporter VGLUT1, we find that glutamate alone fully accounts for the activation of NMDA receptors at exc...
  3. Autism-associated mutation inhibits protein kinase C-mediated neuroligin-4X enhancement of excitatory synapses.

    PNAS 112(8):2551 (2015) PMID 25675530 PMCID PMC4345621

    Autism spectrum disorders (ASDs) comprise a highly heritable, multifarious group of neurodevelopmental disorders, which are characterized by repetitive behaviors and impairments in social interactions. Point mutations have been identified in X-linked Neuroligin (NLGN) 3 and 4X genes in patients ...
  4. Autism-associated mutation inhibits protein kinase C-mediated neuroligin-4X enhancement of excitatory synapses.

    PNAS 112(8):2551 (2015) PMID 25675530 PMCID PMC4345621

    Autism spectrum disorders (ASDs) comprise a highly heritable, multifarious group of neurodevelopmental disorders, which are characterized by repetitive behaviors and impairments in social interactions. Point mutations have been identified in X-linked Neuroligin (NLGN) 3 and 4X genes in patients ...
  5. Relative contribution of TARPs γ-2 and γ-7 to cerebellar excitatory synaptic transmission and motor behavior.

    PNAS 112(4):E371 (2015) PMID 25583485 PMCID PMC4313851

    Transmembrane AMPA receptor regulatory proteins (TARPs) play an essential role in excitatory synaptic transmission throughout the central nervous system (CNS) and exhibit subtype-specific effects on AMPA receptor (AMPAR) trafficking, gating, and pharmacology. The function of TARPs has largely be...
  6. Relative contribution of TARPs γ-2 and γ-7 to cerebellar excitatory synaptic transmission and motor behavior.

    PNAS 112(4):E371 (2015) PMID 25583485 PMCID PMC4313851

    Transmembrane AMPA receptor regulatory proteins (TARPs) play an essential role in excitatory synaptic transmission throughout the central nervous system (CNS) and exhibit subtype-specific effects on AMPA receptor (AMPAR) trafficking, gating, and pharmacology. The function of TARPs has largely be...
  7. Efficient, complete deletion of synaptic proteins using CRISPR.

    Neuron 83(5):1051 (2014) PMID 25155957 PMCID PMC4195490

    One of the most powerful ways to test the function of a protein is to characterize the consequences of its deletion. In the past, this has involved inactivation of the gene by homologous recombination either in the germline or later through conditional deletion. RNA interference (RNAi) provides ...
  8. Retromer mediates a discrete route of local membrane delivery to dendrites.

    Neuron 82(1):55 (2014) PMID 24698268 PMCID PMC4029335

    A fundamental and still largely unresolved question is how neurons achieve rapid delivery of selected signaling receptors throughout the elaborate dendritic arbor. Here we show that this requires a conserved sorting machinery called retromer. Retromer-associated endosomes are distributed within ...
  9. Retromer mediates a discrete route of local membrane delivery to dendrites.

    Neuron 82(1):55 (2014) PMID 24698268 PMCID PMC4029335

    A fundamental and still largely unresolved question is how neurons achieve rapid delivery of selected signaling receptors throughout the elaborate dendritic arbor. Here we show that this requires a conserved sorting machinery called retromer. Retromer-associated endosomes are distributed within ...
  10. A cortical circuit for gain control by behavioral state.

    Cell 156(6):1139 (2014) PMID 24630718 PMCID PMC4041382

    The brain's response to sensory input is strikingly modulated by behavioral state. Notably, the visual response of mouse primary visual cortex (V1) is enhanced by locomotion, a tractable and accessible example of a time-locked change in cortical state. The neural circuits that transmit behaviora...
  11. A cortical circuit for gain control by behavioral state.

    Cell 156(6):1139 (2014) PMID 24630718 PMCID PMC4041382

    The brain's response to sensory input is strikingly modulated by behavioral state. Notably, the visual response of mouse primary visual cortex (V1) is enhanced by locomotion, a tractable and accessible example of a time-locked change in cortical state. The neural circuits that transmit behaviora...
  12. Expression mechanisms underlying long-term potentiation: a postsynaptic view, 10 years on.

    Philosophical Transactions of the Royal Society... 369(1633):20130136 (2014) PMID 24298139 PMCID PMC3843869

    This review focuses on the research that has occurred over the past decade which has solidified a postsynaptic expression mechanism for long-term potentiation (LTP). However, experiments that have suggested a presynaptic component are also summarized. It is argued that the pairing of glutamate u...
  13. Expression mechanisms underlying long-term potentiation: a postsynaptic view, 10 years on.

    Philosophical Transactions of the Royal Society... 369(1633):20130136 (2014) PMID 24298139 PMCID PMC3843869

    This review focuses on the research that has occurred over the past decade which has solidified a postsynaptic expression mechanism for long-term potentiation (LTP). However, experiments that have suggested a presynaptic component are also summarized. It is argued that the pairing of glutamate u...
  14. Expression mechanisms underlying long-term potentiation: a postsynaptic view, 10 years on.

    Philosophical Transactions of the Royal Society... 369(1633):20130136 (2014) PMID 24298139 PMCID PMC3843869

    This review focuses on the research that has occurred over the past decade which has solidified a postsynaptic expression mechanism for long-term potentiation (LTP). However, experiments that have suggested a presynaptic component are also summarized. It is argued that the pairing of glutamate u...
  15. Expression mechanisms underlying long-term potentiation: a postsynaptic view, 10 years on.

    Philosophical Transactions of the Royal Society... 369(1633):20130136 (2014) PMID 24298139 PMCID PMC3843869

    This review focuses on the research that has occurred over the past decade which has solidified a postsynaptic expression mechanism for long-term potentiation (LTP). However, experiments that have suggested a presynaptic component are also summarized. It is argued that the pairing of glutamate u...
  16. LTD expression is independent of glutamate receptor subtype.

    Frontiers in Synaptic Neuroscience 6:15 (2014) PMID 25071549 PMCID PMC4086023

    Long-term depression (LTD) is a form of synaptic plasticity that plays a major role in the activity-dependent reshaping of synaptic transmission. LTD is expressed as a decrease in synaptic AMPA receptor number, though the exact mechanism remains controversial. Several lines of evidence have sugg...
  17. CaMKII phosphorylation of neuroligin-1 regulates excitatory synapses.

    Nature Neuroscience 17(1):56 (2014) PMID 24336150 PMCID PMC3943352

    Neuroligins are postsynaptic cell adhesion molecules that are important for synaptic function through their trans-synaptic interaction with neurexins (NRXNs). The localization and synaptic effects of neuroligin-1 (NL-1, also called NLGN1) are specific to excitatory synapses with the capacity to ...
  18. LTD expression is independent of glutamate receptor subtype.

    Frontiers in Synaptic Neuroscience 6:15 (2014) PMID 25071549 PMCID PMC4086023

    Long-term depression (LTD) is a form of synaptic plasticity that plays a major role in the activity-dependent reshaping of synaptic transmission. LTD is expressed as a decrease in synaptic AMPA receptor number, though the exact mechanism remains controversial. Several lines of evidence have sugg...
  19. CaMKII phosphorylation of neuroligin-1 regulates excitatory synapses.

    Nature Neuroscience 17(1):56 (2014) PMID 24336150 PMCID PMC3943352

    Neuroligins are postsynaptic cell adhesion molecules that are important for synaptic function through their trans-synaptic interaction with neurexins (NRXNs). The localization and synaptic effects of neuroligin-1 (NL-1, also called NLGN1) are specific to excitatory synapses with the capacity to ...
  20. Long-term potentiation: peeling the onion.

    Neuropharmacology 74:18 (2013) PMID 23439383 PMCID PMC3718856

    Since the discovery of long-term potentiation (LTP), thousands of papers have been published on this phenomenon. With this massive amount of information, it is often difficult, especially for someone not directly involved in the field, not to be overwhelmed. The goal of this review is to peel aw...