1. Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors.

    Cell 161(6):1280 (2015) PMID 26004070

    The site on the HIV-1 gp120 glycoprotein that binds the CD4 receptor is recognized by broadly reactive antibodies, several of which neutralize over 90% of HIV-1 strains. To understand how antibodies achieve such neutralization, we isolated CD4-binding-site (CD4bs) antibodies and analyzed 16 co-c...
  2. Defense-in-depth by mucosally administered anti-HIV dimeric IgA2 and systemic IgG1 mAbs: complete protection of rhesus monkeys from mucosal SHIV challenge.

    Vaccine 33(17):2086 (2015) PMID 25769884 PMCID PMC4411954

    Although IgA is the most abundantly produced immunoglobulin in humans, its role in preventing HIV-1 acquisition, which occurs mostly via mucosal routes, remains unclear. In our passive mucosal immunizations of rhesus macaques (RMs), the anti-HIV-1 neutralizing monoclonal antibody (nmAb) HGN194, ...
  3. The clammy grip of parasitic tumors.

    Cell 161(2):191 (2015) PMID 25860599

    An epidemic of leukemia among bivalve molluscs is spreading along the Atlantic coast of North America, with a serious population decline of soft-shelled clams. In this issue of Cell, Metzger et al. use forensic DNA markers to demonstrate that the leukemia cells have a clonal origin and appear to...
  4. Neutralization properties of simian immunodeficiency viruses infecting chimpanzees and gorillas.

    mBio 6(2) (2015) PMID 25900654 PMCID PMC4453581

    Broadly cross-reactive neutralizing antibodies (bNabs) represent powerful tools to combat human immunodeficiency virus type 1 (HIV-1) infection. Here, we examined whether HIV-1-specific bNabs are capable of cross-neutralizing distantly related simian immunodeficiency viruses (SIVs) infecting cen...
  5. Molecular Evolution of Broadly Neutralizing Llama Antibodies to the CD4-Binding Site of HIV-1.

    PLoS Pathogens 10(12):e1004552 (2014) PMID 25522326

    To date, no immunization of humans or animals has elicited broadly neutralizing sera able to prevent HIV-1 transmission; however, elicitation of broad and potent heavy chain only antibodies (HCAb) has previously been reported in llamas. In this study, the anti-HIV immune responses in immunized l...
  6. Molecular evolution of broadly neutralizing llama antibodies to the CD4-binding site of HIV-1.

    PLoS Pathogens 10(12):e1004552 (2014) PMID 25522326 PMCID PMC4270772

    To date, no immunization of humans or animals has elicited broadly neutralizing sera able to prevent HIV-1 transmission; however, elicitation of broad and potent heavy chain only antibodies (HCAb) has previously been reported in llamas. In this study, the anti-HIV immune responses in immunized l...
  7. Molecular Evolution of Broadly Neutralizing Llama Antibodies to the CD4-Binding Site of HIV-1.

    PLoS Pathogens 10(12):e1004552 (2014) PMID 25522326 PMCID PMC4270772

    To date, no immunization of humans or animals has elicited broadly neutralizing sera able to prevent HIV-1 transmission; however, elicitation of broad and potent heavy chain only antibodies (HCAb) has previously been reported in llamas. In this study, the anti-HIV immune responses in immunized l...
  8. Molecular Evolution of Broadly Neutralizing Llama Antibodies to the CD4-Binding Site of HIV-1.

    PLoS Pathogens 10(12):e1004552 (2014) PMID 25522326 PMCID PMC4270772

    To date, no immunization of humans or animals has elicited broadly neutralizing sera able to prevent HIV-1 transmission; however, elicitation of broad and potent heavy chain only antibodies (HCAb) has previously been reported in llamas. In this study, the anti-HIV immune responses in immunized l...
  9. Molecular evolution of broadly neutralizing llama antibodies to the CD4-binding site of HIV-1.

    PLoS Pathogens 10(12):e1004552 (2014) PMID 25522326 PMCID PMC4270772

    To date, no immunization of humans or animals has elicited broadly neutralizing sera able to prevent HIV-1 transmission; however, elicitation of broad and potent heavy chain only antibodies (HCAb) has previously been reported in llamas. In this study, the anti-HIV immune responses in immunized l...
  10. Molecular evolution of broadly neutralizing Llama antibodies to the CD4-binding site of HIV-1.

    PLoS Pathogens 10(12):e1004552 (2014) PMID 25522326 PMCID PMC4270772

    To date, no immunization of humans or animals has elicited broadly neutralizing sera able to prevent HIV-1 transmission; however, elicitation of broad and potent heavy chain only antibodies (HCAb) has previously been reported in llamas. In this study, the anti-HIV immune responses in immunized l...
  11. Transmissible [corrected] dog cancer genome reveals the origin and history of an ancient cell lineage.

    Science 343(6169):437 (2014) PMID 24458646 PMCID PMC3918581

    Canine transmissible venereal tumor (CTVT) is the oldest known somatic cell lineage. It is a transmissible cancer that propagates naturally in dogs. We sequenced the genomes of two CTVT tumors and found that CTVT has acquired 1.9 million somatic substitution mutations and bears evidence of expos...
  12. Transmissible [corrected] dog cancer genome reveals the origin and history of an ancient cell lineage.

    Science 343(6169):437 (2014) PMID 24458646 PMCID PMC3918581

    Canine transmissible venereal tumor (CTVT) is the oldest known somatic cell lineage. It is a transmissible cancer that propagates naturally in dogs. We sequenced the genomes of two CTVT tumors and found that CTVT has acquired 1.9 million somatic substitution mutations and bears evidence of expos...
  13. Transmissible [corrected] dog cancer genome reveals the origin and history of an ancient cell lineage.

    Science 343(6169):437 (2014) PMID 24458646 PMCID PMC3918581

    Canine transmissible venereal tumor (CTVT) is the oldest known somatic cell lineage. It is a transmissible cancer that propagates naturally in dogs. We sequenced the genomes of two CTVT tumors and found that CTVT has acquired 1.9 million somatic substitution mutations and bears evidence of expos...
  14. Transmissible [corrected] dog cancer genome reveals the origin and history of an ancient cell lineage.

    Science 343(6169):437 (2014) PMID 24458646 PMCID PMC3918581

    Canine transmissible venereal tumor (CTVT) is the oldest known somatic cell lineage. It is a transmissible cancer that propagates naturally in dogs. We sequenced the genomes of two CTVT tumors and found that CTVT has acquired 1.9 million somatic substitution mutations and bears evidence of expos...
  15. Immunotherapy for HIV Infection.

    New England Journal of Medicine 370(4):379 (2014) PMID 24450898

  16. Immunotherapy for HIV Infection.

    New England Journal of Medicine 370(4):379 (2014) PMID 24450898

  17. Neutralisation of HIV-1 cell-cell spread by human and llama antibodies.

    Retrovirology 11(1):83 (2014) PMID 25700025 PMCID PMC4189184

    Direct cell-cell spread of HIV-1 is a very efficient mode of viral dissemination, with increasing evidence suggesting that it may pose a considerable challenge to controlling viral replication in vivo. Much current vaccine research involves the study of broadly neutralising antibodies (bNabs) th...
  18. In tribute to Joep Lange.

    Retrovirology 11:82 (2014) PMID 25927561 PMCID PMC4169638

  19. Obituary: Axel Rethwilm (1959-2014).

    Retrovirology 11:85 (2014) PMID 25270643 PMCID PMC4174657

  20. Neutralisation of HIV-1 cell-cell spread by human and llama antibodies.

    Retrovirology 11(1):83 (2014) PMID 25700025 PMCID PMC4189184

    Direct cell-cell spread of HIV-1 is a very efficient mode of viral dissemination, with increasing evidence suggesting that it may pose a considerable challenge to controlling viral replication in vivo. Much current vaccine research involves the study of broadly neutralising antibodies (bNabs) th...