1. Reversal of Arthritis by Human Monomeric IgA Through the Receptor-Mediated SH2 Domain-Containing Phosphatase 1 Inhibitory Pathway.

    Arthritis & rheumatology (Hoboken, N.J.) 67(7):1766 (2015) PMID 25833812

    Rheumatoid arthritis (RA), one of the most frequent chronic inflammatory rheumatic disorders, is characterized by the presence of autoantibodies and joint infiltration by activated immune cells, leading to cartilage and bone destruction. IgA occurs predominantly as monomers (mIgA) in plasma and ...
  2. The function of mast cells in autoimmune glomerulonephritis.

    Methods in Molecular Biology 1220:487 (2015) PMID 25388269

    Immune-mediated glomerulonephritis is caused by deposition of immune complexes on the glomerular basement membrane or of autoantibodies directed against the glomerular basement membrane. Depositions lead to an inflammatory response that can ultimately destroy renal function and lead to chronic k...
  3. The function of mast cells in autoimmune glomerulonephritis.

    Methods in Molecular Biology 1220:487 (2015) PMID 25388269

    Immune-mediated glomerulonephritis is caused by deposition of immune complexes on the glomerular basement membrane or of autoantibodies directed against the glomerular basement membrane. Depositions lead to an inflammatory response that can ultimately destroy renal function and lead to chronic k...
  4. The function of mast cells in autoimmune glomerulonephritis.

    Methods in Molecular Biology 1220:487 (2015) PMID 25388269

    Immune-mediated glomerulonephritis is caused by deposition of immune complexes on the glomerular basement membrane or of autoantibodies directed against the glomerular basement membrane. Depositions lead to an inflammatory response that can ultimately destroy renal function and lead to chronic k...
  5. Mast cells aggravate sepsis by inhibiting peritoneal macrophage phagocytosis.

    Journal of Clinical Investigation 124(10):4577 (2014) PMID 25180604 PMCID PMC4191002

    Controlling the overwhelming inflammatory reaction associated with polymicrobial sepsis remains a prevalent clinical challenge with few treatment options. In septic peritonitis, blood neutrophils and monocytes are rapidly recruited into the peritoneal cavity to control infection, but the role of...
  6. Mast cells aggravate sepsis by inhibiting peritoneal macrophage phagocytosis.

    Journal of Clinical Investigation 124(10):4577 (2014) PMID 25180604 PMCID PMC4191002

    Controlling the overwhelming inflammatory reaction associated with polymicrobial sepsis remains a prevalent clinical challenge with few treatment options. In septic peritonitis, blood neutrophils and monocytes are rapidly recruited into the peritoneal cavity to control infection, but the role of...
  7. Mast cells aggravate sepsis by inhibiting peritoneal macrophage phagocytosis.

    Journal of Clinical Investigation 124(10):4577 (2014) PMID 25180604 PMCID PMC4191002

    Controlling the overwhelming inflammatory reaction associated with polymicrobial sepsis remains a prevalent clinical challenge with few treatment options. In septic peritonitis, blood neutrophils and monocytes are rapidly recruited into the peritoneal cavity to control infection, but the role of...
  8. Mast cells aggravate sepsis by inhibiting peritoneal macrophage phagocytosis.

    Journal of Clinical Investigation 124(10):4577 (2014) PMID 25180604 PMCID PMC4191002

    Controlling the overwhelming inflammatory reaction associated with polymicrobial sepsis remains a prevalent clinical challenge with few treatment options. In septic peritonitis, blood neutrophils and monocytes are rapidly recruited into the peritoneal cavity to control infection, but the role of...
  9. Shifting FcγRIIA-ITAM from activation to inhibitory configuration ameliorates arthritis.

    Journal of Clinical Investigation 124(9):3945 (2014) PMID 25061875 PMCID PMC4151227

    Rheumatoid arthritis-associated (RA-associated) inflammation is mediated through the interaction between RA IgG immune complexes and IgG Fc receptors on immune cells. Polymorphisms within the gene encoding the human IgG Fc receptor IIA (hFcγRIIA) are associated with an increased risk of developi...
  10. Shifting FcγRIIA-ITAM from activation to inhibitory configuration ameliorates arthritis.

    Journal of Clinical Investigation 124(9):3945 (2014) PMID 25061875 PMCID PMC4151227

    Rheumatoid arthritis-associated (RA-associated) inflammation is mediated through the interaction between RA IgG immune complexes and IgG Fc receptors on immune cells. Polymorphisms within the gene encoding the human IgG Fc receptor IIA (hFcγRIIA) are associated with an increased risk of developi...
  11. Shifting FcγRIIA-ITAM from activation to inhibitory configuration ameliorates arthritis.

    Journal of Clinical Investigation 124(9):3945 (2014) PMID 25061875 PMCID PMC4151227

    Rheumatoid arthritis-associated (RA-associated) inflammation is mediated through the interaction between RA IgG immune complexes and IgG Fc receptors on immune cells. Polymorphisms within the gene encoding the human IgG Fc receptor IIA (hFcγRIIA) are associated with an increased risk of developi...
  12. Role of FcγRIIIA (CD16) in IVIg-mediated anti-inflammatory function.

    Journal of Clinical Immunology 34 Suppl 1:S46 (2014) PMID 24728843

    The mechanism for anti-inflammatory action of intravenous immunoglobulin (IVIg) in the treatment of autoimmune and inflammatory diseases involves IgG Fc receptors (FcγR). Although the inhibitory FcγRIIB plays an important role in IVIg action, FcγRIIIA has recently been identified as another majo...
  13. Role of FcγRIIIA (CD16) in IVIg-mediated anti-inflammatory function.

    Journal of Clinical Immunology 34 Suppl 1:S46 (2014) PMID 24728843

    The mechanism for anti-inflammatory action of intravenous immunoglobulin (IVIg) in the treatment of autoimmune and inflammatory diseases involves IgG Fc receptors (FcγR). Although the inhibitory FcγRIIB plays an important role in IVIg action, FcγRIIIA has recently been identified as another majo...
  14. Balance between the two kinin receptors in the progression of experimental focal and segmental glomerulosclerosis in mice.

    Disease Models & Mechanisms 7(6):701 (2014) PMID 24742784 PMCID PMC4036477

    Focal and segmental glomerulosclerosis (FSGS) is one of the most important renal diseases related to end-stage renal failure. Bradykinin has been implicated in the pathogenesis of renal inflammation, whereas the role of its receptor 2 (B2RBK; also known as BDKRB2) in FSGS has not been studied. F...
  15. Balance between the two kinin receptors in the progression of experimental focal and segmental glomerulosclerosis in mice.

    Disease Models & Mechanisms 7(6):701 (2014) PMID 24742784 PMCID PMC4036477

    Focal and segmental glomerulosclerosis (FSGS) is one of the most important renal diseases related to end-stage renal failure. Bradykinin has been implicated in the pathogenesis of renal inflammation, whereas the role of its receptor 2 (B2RBK; also known as BDKRB2) in FSGS has not been studied. F...
  16. Balance between the two kinin receptors in the progression of experimental focal and segmental glomerulosclerosis in mice.

    Disease Models & Mechanisms 7(6):701 (2014) PMID 24742784 PMCID PMC4036477

    Focal and segmental glomerulosclerosis (FSGS) is one of the most important renal diseases related to end-stage renal failure. Bradykinin has been implicated in the pathogenesis of renal inflammation, whereas the role of its receptor 2 (B2RBK; also known as BDKRB2) in FSGS has not been studied. F...
  17. IgA, IgA receptors, and their anti-inflammatory properties.

    Current Topics in Microbiology and Immunology 382:221 (2014) PMID 25116102

    Immunoglobulin A (IgA) is the most abundantly produced antibody isotype in mammals. The primary function of IgA is to maintain homeostasis at mucosal surfaces and play a role in immune protection. IgA functions mainly through interaction with multiple receptors including IgA Fc receptor I (FcαRI...
  18. Regulation of the tyrosine phosphorylation of Phospholipid Scramblase 1 in mast cells that are stimulated through the high-affinity IgE receptor.

    PLoS ONE 9(10):e109800 (2014) PMID 25289695 PMCID PMC4188579

    Engagement of high-affinity immunoglobulin E receptors (FcεRI) activates two signaling pathways in mast cells. The Lyn pathway leads to recruitment of Syk and to calcium mobilization whereas the Fyn pathway leads to phosphatidylinositol 3-kinase recruitment. Mapping the connections between both ...
  19. Regulation of the tyrosine phosphorylation of Phospholipid Scramblase 1 in mast cells that are stimulated through the high-affinity IgE receptor.

    PLoS ONE 9(10):e109800 (2014) PMID 25289695 PMCID PMC4188579

    Engagement of high-affinity immunoglobulin E receptors (FcεRI) activates two signaling pathways in mast cells. The Lyn pathway leads to recruitment of Syk and to calcium mobilization whereas the Fyn pathway leads to phosphatidylinositol 3-kinase recruitment. Mapping the connections between both ...
  20. IgA, IgA receptors, and their anti-inflammatory properties.

    Current Topics in Microbiology and Immunology 382:221 (2014) PMID 25116102

    Immunoglobulin A (IgA) is the most abundantly produced antibody isotype in mammals. The primary function of IgA is to maintain homeostasis at mucosal surfaces and play a role in immune protection. IgA functions mainly through interaction with multiple receptors including IgA Fc receptor I (FcαRI...