1. Biologic Responses to Weight Loss and Weight Regain: Report From an American Diabetes Association Research Symposium.

    Diabetes 64(7):2299 (2015) PMID 26106187

  2. Insulin Detemir Is Transported From Blood to Cerebrospinal Fluid and Has Prolonged Central Anorectic Action Relative to NPH Insulin.

    Diabetes 64(7):2457 (2015) PMID 25667307 PMCID PMC4477354

    Insulin detemir (DET) reduces glycemia comparably to other long-acting insulin formulations but causes less weight gain. Insulin signaling in the brain is catabolic, reducing food intake. We hypothesized that DET reduces weight gain, relative to other insulins, owing to increased transport into ...
  3. Diet-induced obesity exacerbates metabolic and behavioral effects of polycystic ovary syndrome in a rodent model.

    American Journal of Physiology - Endocrinology ... 308(12):E1076 (2015) PMID 26078189 PMCID PMC4469809

    Polycystic ovary syndrome (PCOS) is the most common endocrinopathy affecting women of reproductive age. Although a comorbidity of PCOS is obesity, many are lean. We hypothesized that increased saturated fat consumption and obesity would exacerbate metabolic and stress indices in a rodent model o...
  4. Adipocyte glucocorticoid receptors mediate fat-to-brain signaling.

    Psychoneuroendocrinology 56:110 (2015) PMID 25808702 PMCID PMC4511277

    Stress-related (e.g., depression) and metabolic pathologies (e.g., obesity) are important and often co-morbid public health concerns. Here we identify a connection between peripheral glucocorticoid receptor (GR) signaling originating in fat with the brain control of both stress and metabolism. M...
  5. The melanocortin-4 receptor integrates circadian light cues and metabolism.

    Endocrinology 156(5):1685 (2015) PMID 25730108 PMCID PMC4398770

    The melanocortin system directs diverse physiological functions from coat color to body weight homoeostasis. A commonality among melanocortin-mediated processes is that many animals modulate similar processes on a circannual basis in response to longer, summer days, suggesting an underlying link...
  6. The Hunger Games

    Cell 160(5):805 (2015)

    Although AgRP and POMC neurons in the hypothalamus have long been associated with regulation of food intake, in this issue of Cell, Chen et al. use direct imaging in vivo to demonstrate rapid changes in their activity upon food presentation. The rapidity of their altered responses chal...
  7. The hunger games.

    Cell 160(5):805 (2015) PMID 25723156

    Although AgRP and POMC neurons in the hypothalamus have long been associated with regulation of food intake, in this issue of Cell, Chen et al. use direct imaging in vivo to demonstrate rapid changes in their activity upon food presentation. The rapidity of their altered responses challenges cla...
  8. The hunger games.

    Cell 160(5):805 (2015) PMID 25723156

    Although AgRP and POMC neurons in the hypothalamus have long been associated with regulation of food intake, in this issue of Cell, Chen et al. use direct imaging in vivo to demonstrate rapid changes in their activity upon food presentation. The rapidity of their altered responses challenges cla...
  9. Mechanisms underlying weight loss and metabolic improvements in rodent models of bariatric surgery.

    Diabetologia 58(2):211 (2015) PMID 25374275

    Obesity is a growing health risk with few successful treatment options and fewer still that target both obesity and obesity-associated comorbidities. Despite ongoing scientific efforts, the most effective treatment option to date was not developed from basic research but by surgeons observing ou...
  10. Mechanisms underlying weight loss and metabolic improvements in rodent models of bariatric surgery.

    Diabetologia 58(2):211 (2015) PMID 25374275 PMCID PMC4289431

    Obesity is a growing health risk with few successful treatment options and fewer still that target both obesity and obesity-associated comorbidities. Despite ongoing scientific efforts, the most effective treatment option to date was not developed from basic research but by surgeons observing ou...
  11. Mechanisms underlying weight loss and metabolic improvements in rodent models of bariatric surgery.

    Diabetologia 58(2):211 (2015) PMID 25374275

    Obesity is a growing health risk with few successful treatment options and fewer still that target both obesity and obesity-associated comorbidities. Despite ongoing scientific efforts, the most effective treatment option to date was not developed from basic research but by surgeons observing ou...
  12. Mechanisms underlying weight loss and metabolic improvements in rodent models of bariatric surgery.

    Diabetologia 58(2):211 (2015) PMID 25374275 PMCID PMC4289431

    Obesity is a growing health risk with few successful treatment options and fewer still that target both obesity and obesity-associated comorbidities. Despite ongoing scientific efforts, the most effective treatment option to date was not developed from basic research but by surgeons observing ou...
  13. Mechanisms underlying weight loss and metabolic improvements in rodent models of bariatric surgery.

    Diabetologia 58(2):211 (2015) PMID 25374275 PMCID PMC4289431

    Obesity is a growing health risk with few successful treatment options and fewer still that target both obesity and obesity-associated comorbidities. Despite ongoing scientific efforts, the most effective treatment option to date was not developed from basic research but by surgeons observing ou...
  14. Vertical Sleeve Gastrectomy Restores Glucose Homeostasis in Apolipoprotein A-IV KO Mice.

    Diabetes 64(2):498 (2015) PMID 25157093 PMCID PMC4303973

    Bariatric surgery is the most successful strategy for treating obesity, yet the mechanisms for this success are not clearly understood. Clinical literature suggests that plasma levels of apolipoprotein A-IV (apoA-IV) rise with Roux-en-Y gastric bypass (RYGB). apoA-IV is secreted from the intesti...
  15. Mechanisms underlying weight loss and metabolic improvements in rodent models of bariatric surgery.

    Diabetologia 58(2):211 (2015) PMID 25374275

    Obesity is a growing health risk with few successful treatment options and fewer still that target both obesity and obesity-associated comorbidities. Despite ongoing scientific efforts, the most effective treatment option to date was not developed from basic research but by surgeons observing ou...
  16. Vertical sleeve gastrectomy restores glucose homeostasis in apolipoprotein A-IV KO mice.

    Diabetes 64(2):498 (2015) PMID 25157093 PMCID PMC4303973

    Bariatric surgery is the most successful strategy for treating obesity, yet the mechanisms for this success are not clearly understood. Clinical literature suggests that plasma levels of apolipoprotein A-IV (apoA-IV) rise with Roux-en-Y gastric bypass (RYGB). apoA-IV is secreted from the intesti...
  17. A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents.

    Nature Medicine 21(1):27 (2015) PMID 25485909

    We report the discovery of a new monomeric peptide that reduces body weight and diabetic complications in rodent models of obesity by acting as an agonist at three key metabolically-related peptide hormone receptors: glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (...
  18. A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents.

    Nature Medicine 21(1):27 (2015) PMID 25485909

    We report the discovery of a new monomeric peptide that reduces body weight and diabetic complications in rodent models of obesity by acting as an agonist at three key metabolically-related peptide hormone receptors: glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (...
  19. Bile Acid Signaling: Mechanism for Bariatric Surgery, Cure for NASH?

    Digestive Diseases: clinical reviews 33(3):440 (2015) PMID 26045281

    Bariatric surgery is the most effective and durable treatment option for obesity today. More importantly, beyond weight loss, bariatric procedures have many advantageous metabolic effects including reversal of obesity-related liver disease - nonalcoholic steatohepatitis (NASH). NASH is an import...
  20. Adipocyte Glucocorticoid Receptors Mediate Fat-To-Brain Signaling

    Psychoneuroendocrinology (2015)

    • Mice with reduced adipocyte GR hypersecrete glucocorticoids following acute stress. • Adipocyte GR knockdown mice have impaired negative feedback of the HPA axis...