1. Whole-genome DNA methylation and hydroxymethylation profiling for HBV-related hepatocellular carcinoma.

    International Journal of Oncology 49(2):589 (2016) PMID 27221337

    Hepatocellular carcinoma (HCC) is a common solid tumor worldwide with a poor prognosis. Accumulating evidence has implicated important regulatory roles of epigenetic modifications in the occurrence and progression of HCC. In the present study, we analyzed 5-methylcytosine (5-mC) and 5-hydroxymet...
  2. Dynamic regulation of RNA editing in human brain development and disease.

    Nature Neuroscience 19(8):1093 (2016) PMID 27348216

    RNA editing is increasingly recognized as a molecular mechanism regulating RNA activity and recoding proteins. Here we surveyed the global landscape of RNA editing in human brain tissues and identified three unique patterns of A-to-I RNA editing rates during cortical development: stable high, st...
  3. A human-specific AS3MT isoform and BORCS7 are molecular risk factors in the 10q24.32 schizophrenia-associated locus.

    Nature Medicine 22(6):649 (2016) PMID 27158905

    Genome-wide association studies (GWASs) have reported many single nucleotide polymorphisms (SNPs) associated with psychiatric disorders, but knowledge is lacking regarding molecular mechanisms. Here we show that risk alleles spanning multiple genes across the 10q24.32 schizophrenia-related locus...
  4. Primary hepatic epithelioid angiomyolipoma: A malignant potential tumor which should be recognized.

    World Journal of Gastroenterology 22(20):4908 (2016) PMID 27239117 PMCID PMC4873883

    To improve the clinical diagnosis and recognition of hepatic epithelioid angiomyolipoma (HEAML). Four cases of primary HEAML were confirmed based on the pathology archive system in our hospital from January 2009 to November 2015. The general state, clinical symptoms, imaging manifestations, hist...
  5. Geometries, Electronic Couplings, and Hole Dissociation Dynamics of Photoinduced Electron-Hole Pairs in Polyhexylthiophene-Fullerene Dyads Rigidly Linked by Oligophenylenes.

    Journal of the American Chemical Society 138(18):5879 (2016) PMID 27082279

    To shed a light on fundamental molecular functions of photoinduced charge conductions by organic photovoltaic materials, it is important to directly observe molecular geometries of the intermediate charges just after the photoinduced electron-transfer reactions. However, highly inhomogeneous mol...
  6. TRAM1 protects AR42J cells from caerulein-induced acute pancreatitis through ER stress-apoptosis pathway.

    In Vitro Cellular & Developmental Biology - Animal 52(5):530 (2016) PMID 27105999

    Chronic endoplasmic reticulum (ER) stress in pancreatic acinar cells has emerged as a major contributor to the recovery of acute pancreatitis (AP). However, the molecular mechanisms linking AP and ER stress remain not fully understood. In this study, we employed caerulein to induce AP-like infla...
  7. SGTB Promotes the Caspase-Dependent Apoptosis in Chondrocytes of Osteoarthritis.

    Inflammation 39(2):601 (2016) PMID 26586481

    The purpose of this study is to investigate the expression of small glutamine-rich tetratricopeptide repeat (TPR)-containing β (SGTB) in articular cartilage of osteoarthritis (OA) and analyze the relationship between SGTB and chondrocyte apoptosis. We established an OA rat model by the meniscal/...
  8. HDAC and PI3K Antagonists Cooperate to Inhibit Growth of MYC-Driven Medulloblastoma.

    Cancer Cell 29(3):311 (2016) PMID 26977882 PMCID PMC4794752

    Medulloblastoma (MB) is a highly malignant pediatric brain tumor. Despite aggressive therapy, many patients succumb to the disease, and survivors experience severe side effects from treatment. MYC-driven MB has a particularly poor prognosis and would greatly benefit from more effective therapies...
  9. Randomized nonuniform sampling and reconstruction in fractional Fourier domain

    Signal Processing 120:311 (2016)

    The fractional Fourier transform (FRFT) is one of the most useful tools for the nonstationary signal processing. In this paper, the randomized nonuniform sampling and approximate reconstruction of the nonstationary random signals in the fractional Fourier domain (FRFD) are developed. T...
  10. A highly photoconductive composite prepared by incorporating polyoxometalate into perovskite for photodetection application.

    Chemical Communications 52(16):3304 (2016) PMID 26818431

    A photoconductive perovskite-polyoxometalate composite was prepared for the first time by a facile low-temperature and solution-processed method, and this composite exhibited a significantly enhanced photoconductivity and photodetection performance due to introduction of polyoxometalate into the...
  11. The power of subliminal and supraliminal eye contact on social decision making: An individual-difference perspective.

    Consciousness and Cognition 40:131 (2016) PMID 26821242

    We conducted two experiments to explore how social decision making is influenced by the interaction of eye contact and social value orientation (SVO). Specifically, participants with a Prosocial (Prosocials) or a Proself (Proselfs) SVO played Prisoner Dilemma games with a computer partner follow...
  12. Pyrroloquinoline Quinone Decelerates Rheumatoid Arthritis Progression by Inhibiting Inflammatory Responses and Joint Destruction via Modulating NF-κB and MAPK Pathways.

    Inflammation 39(1):248 (2016) PMID 26319019

    Pyrroloquinoline quinone (PQQ) is a naturally occurring redox cofactor that acts as an essential nutrient and antioxidant and has been reported to exert potent immunosuppressive effects. However, the therapeutically potential of PQQ on rheumatoid arthritis (RA) has not been explored. In the pres...
  13. Strong Components of Epigenetic Memory in Cultured Human Fibroblasts Related to Site of Origin and Donor Age.

    PLoS Genetics 12(2):e1005819 (2016) PMID 26913521 PMCID PMC4767228

    Differentiating pluripotent cells from fibroblast progenitors is a potentially transformative tool in personalized medicine. We previously identified relatively greater success culturing dura-derived fibroblasts than scalp-derived fibroblasts from postmortem tissue. We hypothesized that these di...
  14. [Research Progress in Mechanisms Associated with Latent Infection in Humans by the Cytomegalovirus].

    Bing du xue bao = Chinese journal of virology /... 32(1):82 (2016) PMID 27295888

    The human cytomegalovirus (HCMV) is a widespread herpesvirus. Virus reactivation from latency can lead to stillbirth, miscarriage, fetal anomalies, and intrauterine growth retardation. During latent infection with the HCMV, the virus can be cleared by the immune response or apoptosis of host cel...
  15. mTOR Inhibition Attenuates Dextran Sulfate Sodium-Induced Colitis by Suppressing T Cell Proliferation and Balancing TH1/TH17/Treg Profile.

    PLoS ONE 11(4):e0154564 (2016) PMID 27128484 PMCID PMC4851424

    It has been established that mammalian target of Rapamycin (mTOR) inhibitors have anti-inflammatory effects in models of experimental colitis. However, the underlying mechanism is largely unknown. In this research, we investigate the anti-inflammatory effects of AZD8055, a potent mTOR inhibitor,...
  16. Griffiths et al.'s comments on the international consensus statement of internet gaming disorder: furthering consensus or hindering progress?

    British journal of addiction 111(1):175 (2016) PMID 26669531

  17. Mapping DNA methylation across development, genotype and schizophrenia in the human frontal cortex.

    Nature Neuroscience 19(1):40 (2016) PMID 26619358 PMCID PMC4783176

    DNA methylation (DNAm) is important in brain development and is potentially important in schizophrenia. We characterized DNAm in prefrontal cortex from 335 non-psychiatric controls across the lifespan and 191 patients with schizophrenia and identified widespread changes in the transition from pr...
  18. GAD2 Alternative Transcripts in the Human Prefrontal Cortex, and in Schizophrenia and Affective Disorders.

    PLoS ONE 11(2):e0148558 (2016) PMID 26848839 PMCID PMC4744057

    Genetic variation and early adverse environmental events work together to increase risk for schizophrenia. γ-aminobutyric acid (GABA), the major inhibitory neurotransmitter in adult mammalian brain, plays a major role in normal brain development, and has been strongly implicated in the pathobiol...
  19. KPNA2 Contributes to the Inflammatory Processes in Synovial Tissue of Patients with Rheumatoid Arthritis and SW982 Cells.

    Inflammation 38(6):2224 (2015) PMID 26135850

    Karyopherin-α2 (KPNA2) functions as an adaptor that transports several proteins to the nucleus. We investigated the function and possible mechanisms of KPNA2 involved in rheumatoid arthritis (RA). Western blotting and immunohistochemistry showed the protein expression of KPNA2 increased in synov...
  20. The possible role of EZH2 and DNMT1 polymorphisms in sporadic triple-negative breast carcinoma in southern Chinese females.

    Tumor Biology 36(12):9849 (2015) PMID 26162541

    Triple-negative breast cancer (TNBC) has a more invasive and metastatic potential than the other types of breast cancer and hence is associated with poor prognosis. Zeste homolog 2 (EZH2) and DNA methyltransferase 1 (DNMT1) could lead to tumorigenesis by separately methylating histone H3K27 and ...