1. CARMA3 Is Critical for the Initiation of Allergic Airway Inflammation.

    Journal of Immunology 195(2):683 (2015) PMID 26041536 PMCID PMC4489191

    Innate immune responses to allergens by airway epithelial cells (AECs) help initiate and propagate the adaptive immune response associated with allergic airway inflammation in asthma. Activation of the transcription factor NF-κB in AECs by allergens or secondary mediators via G protein-coupled r...
  2. Integrated Genomics of Crohn's Disease Risk Variant Identifies a Role for CLEC12A in Antibacterial Autophagy.

    Cell Reports 11(12):1905 (2015) PMID 26095365 PMCID PMC4507440

    The polymorphism ATG16L1 T300A, associated with increased risk of Crohn's disease, impairs pathogen defense mechanisms including selective autophagy, but specific pathway interactions altered by the risk allele remain unknown. Here, we use perturbational profiling of human peripheral blood cells...
  3. An integrative view of microbiome-host interactions in inflammatory bowel diseases.

    Cell Host & Microbe 17(5):577 (2015) PMID 25974300 PMCID PMC4498258

    The intestinal microbiota, which is composed of bacteria, viruses, and micro-eukaryotes, acts as an accessory organ system with distinct functions along the intestinal tract that are critical for health. This review focuses on how the microbiota drives intestinal disease through alterations in m...
  4. Discovery of a Small-Molecule Probe for V-ATPase Function.

    Journal of the American Chemical Society 137(16):5563 (2015) PMID 25860544 PMCID PMC4416280

    Lysosomes perform a critical cellular function as a site of degradation for diverse cargoes including proteins, organelles, and pathogens delivered through distinct pathways, and defects in lysosomal function have been implicated in a number of diseases. Recent studies have elucidated roles for ...
  5. Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature.

    Journal of Clinical Investigation 125(3):1363 (2015) PMID 25729854

  6. The dynamics of the human infant gut microbiome in development and in progression toward type 1 diabetes.

    Cell Host & Microbe 17(2):260 (2015) PMID 25662751

    Colonization of the fetal and infant gut microbiome results in dynamic changes in diversity, which can impact disease susceptibility. To examine the relationship between human gut microbiome dynamics throughout infancy and type 1 diabetes (T1D), we examined a cohort of 33 infants genetically pre...
  7. The Dynamics of the Human Infant Gut Microbiome in Development and in Progression toward Type 1 Diabetes.

    Cell Host & Microbe 17(2):260 (2015) PMID 25662751

    Colonization of the fetal and infant gut microbiome results in dynamic changes in diversity, which can impact disease susceptibility. To examine the relationship between human gut microbiome dynamics throughout infancy and type 1 diabetes (T1D), we examined a cohort of 33 infants genetically pre...
  8. The Dynamics of the Human Infant Gut Microbiome in Development and in Progression toward Type 1 Diabetes

    Cell Host & Microbe 17(2):260 (2015)

    Colonization of the fetal and infant gut microbiome results in dynamic changes in diversity, which can impact disease susceptibility. To examine the relationship between human gut microbiome dynamics throughout infancy and type 1 diabetes (T1D), we examined a cohort of 33 infants genet...
  9. Disease-specific alterations in the enteric virome in inflammatory bowel disease.

    Cell 160(3):447 (2015) PMID 25619688 PMCID PMC4312520

    Decreases in the diversity of enteric bacterial populations are observed in patients with Crohn's disease (CD) and ulcerative colitis (UC). Less is known about the virome in these diseases. We show that the enteric virome is abnormal in CD and UC patients. In-depth analysis of preparations enric...
  10. Disease-specific alterations in the enteric virome in inflammatory bowel disease.

    Cell 160(3):447 (2015) PMID 25619688

    Decreases in the diversity of enteric bacterial populations are observed in patients with Crohn's disease (CD) and ulcerative colitis (UC). Less is known about the virome in these diseases. We show that the enteric virome is abnormal in CD and UC patients. In-depth analysis of preparations enric...
  11. Disease-specific alterations in the enteric virome in inflammatory bowel disease.

    Cell 160(3):447 (2015) PMID 25619688 PMCID PMC4312520

    Decreases in the diversity of enteric bacterial populations are observed in patients with Crohn's disease (CD) and ulcerative colitis (UC). Less is known about the virome in these diseases. We show that the enteric virome is abnormal in CD and UC patients. In-depth analysis of preparations enric...
  12. Disease-specific alterations in the enteric virome in inflammatory bowel disease.

    Cell 160(3):447 (2015) PMID 25619688 PMCID PMC4312520

    Decreases in the diversity of enteric bacterial populations are observed in patients with Crohn's disease (CD) and ulcerative colitis (UC). Less is known about the virome in these diseases. We show that the enteric virome is abnormal in CD and UC patients. In-depth analysis of preparations enric...
  13. Disease-specific alterations in the enteric virome in inflammatory bowel disease.

    Cell 160(3):447 (2015) PMID 25619688

    Decreases in the diversity of enteric bacterial populations are observed in patients with Crohn's disease (CD) and ulcerative colitis (UC). Less is known about the virome in these diseases. We show that the enteric virome is abnormal in CD and UC patients. In-depth analysis of preparations enric...
  14. Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages

    Cell Metabolism 21(1):65 (2015)

    Macrophages activated by the TLR4 agonist LPS undergo dramatic changes in their metabolic activity. We here show that LPS induces expression of the key metabolic regulator Pyruvate Kinase M2 (PKM2). Activation of PKM2 using two well-characterized small molecules, DASA-58 and TEPP-46, i...
  15. Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages.

    Cell Metabolism 21(1):65 (2015) PMID 25565206

    Macrophages activated by the TLR4 agonist LPS undergo dramatic changes in their metabolic activity. We here show that LPS induces expression of the key metabolic regulator Pyruvate Kinase M2 (PKM2). Activation of PKM2 using two well-characterized small molecules, DASA-58 and TEPP-46, inhibited L...
  16. Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages.

    Cell Metabolism 21(1):65 (2015) PMID 25565206

    Macrophages activated by the TLR4 agonist LPS undergo dramatic changes in their metabolic activity. We here show that LPS induces expression of the key metabolic regulator Pyruvate Kinase M2 (PKM2). Activation of PKM2 using two well-characterized small molecules, DASA-58 and TEPP-46, inhibited L...
  17. Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages.

    Cell Metabolism 21(1):65 (2015) PMID 25565206

    Macrophages activated by the TLR4 agonist LPS undergo dramatic changes in their metabolic activity. We here show that LPS induces expression of the key metabolic regulator Pyruvate Kinase M2 (PKM2). Activation of PKM2 using two well-characterized small molecules, DASA-58 and TEPP-46, inhibited L...
  18. Autophagy and checkpoints for intracellular pathogen defense.

    Current Opinion in Gastroenterology 31(1):14 (2015) PMID 25394238

    Autophagy plays a crucial role in intracellular defense against various pathogens. Xenophagy is a form of selective autophagy that targets intracellular pathogens for degradation. In addition, several related, yet distinct, intracellular defense responses depend on autophagy-related genes. This ...
  19. The kinase DYRK1A reciprocally regulates the differentiation of Th17 and regulatory T cells.

    eLife 4 (2015) PMID 25998054 PMCID PMC4441007

    The balance between Th17 and T regulatory (Treg) cells critically modulates immune homeostasis, with an inadequate Treg response contributing to inflammatory disease. Using an unbiased chemical biology approach, we identified a novel role for the dual specificity tyrosine-phosphorylation-regulat...
  20. Autophagy and checkpoints for intracellular pathogen defense.

    Current Opinion in Gastroenterology 31(1):14 (2015) PMID 25394238

    Autophagy plays a crucial role in intracellular defense against various pathogens. Xenophagy is a form of selective autophagy that targets intracellular pathogens for degradation. In addition, several related, yet distinct, intracellular defense responses depend on autophagy-related genes. This ...