1. A dominant role for the methyl-CpG-binding protein Mbd2 in controlling Th2 induction by dendritic cells.

    Nature Communications 6:6920 (2015) PMID 25908537 PMCID PMC4413429

    Dendritic cells (DCs) direct CD4(+) T-cell differentiation into diverse helper (Th) subsets that are required for protection against varied infections. However, the mechanisms used by DCs to promote Th2 responses, which are important both for immunity to helminth infection and in allergic diseas...
  2. RNA:DNA hybrids are a novel molecular pattern sensed by TLR9.

    EMBO Journal 33(6):542 (2014) PMID 24514026 PMCID PMC3989650

    The sensing of nucleic acids by receptors of the innate immune system is a key component of antimicrobial immunity. RNA:DNA hybrids, as essential intracellular replication intermediates generated during infection, could therefore represent a class of previously uncharacterised pathogen-associate...
  3. RNA:DNA hybrids are a novel molecular pattern sensed by TLR9.

    EMBO Journal 33(6):542 (2014) PMID 24514026 PMCID PMC3989650

    The sensing of nucleic acids by receptors of the innate immune system is a key component of antimicrobial immunity. RNA:DNA hybrids, as essential intracellular replication intermediates generated during infection, could therefore represent a class of previously uncharacterised pathogen-associate...
  4. RNA:DNA hybrids are a novel molecular pattern sensed by TLR9.

    EMBO Journal 33(6):542 (2014) PMID 24514026 PMCID PMC3989650

    The sensing of nucleic acids by receptors of the innate immune system is a key component of antimicrobial immunity. RNA:DNA hybrids, as essential intracellular replication intermediates generated during infection, could therefore represent a class of previously uncharacterised pathogen-associate...
  5. Parasite-derived microRNAs in host serum as novel biomarkers of helminth infection.

    PLoS Neglected Tropical Diseases 8(2):e2701 (2014) PMID 24587461 PMCID PMC3930507

    MicroRNAs (miRNAs) are a class of short non-coding RNA that play important roles in disease processes in animals and are present in a highly stable cell-free form in body fluids. Here, we examine the capacity of host and parasite miRNAs to serve as tissue or serum biomarkers of Schistosoma manso...
  6. Parasite-derived microRNAs in host serum as novel biomarkers of helminth infection.

    PLoS Neglected Tropical Diseases 8(2):e2701 (2014) PMID 24587461 PMCID PMC3930507

    MicroRNAs (miRNAs) are a class of short non-coding RNA that play important roles in disease processes in animals and are present in a highly stable cell-free form in body fluids. Here, we examine the capacity of host and parasite miRNAs to serve as tissue or serum biomarkers of Schistosoma manso...
  7. Parasite-derived microRNAs in host serum as novel biomarkers of helminth infection.

    PLoS Neglected Tropical Diseases 8(2):e2701 (2014) PMID 24587461 PMCID PMC3930507

    MicroRNAs (miRNAs) are a class of short non-coding RNA that play important roles in disease processes in animals and are present in a highly stable cell-free form in body fluids. Here, we examine the capacity of host and parasite miRNAs to serve as tissue or serum biomarkers of Schistosoma manso...
  8. NK cells and conventional dendritic cells engage in reciprocal activation for the induction of inflammatory responses during Plasmodium berghei ANKA infection.

    Immunobiology 218(2):263 (2013) PMID 22704523

    Cerebral malaria (CM) is the most severe syndrome associated with Plasmodium falciparum infections. Experimental evidence suggests that disease results from the sequestration of parasitized-red blood cells (pRBCs) together with inflammatory leukocytes within brain capillaries. We have previously...
  9. NK cells and conventional dendritic cells engage in reciprocal activation for the induction of inflammatory responses during Plasmodium berghei ANKA infection.

    Immunobiology 218(2):263 (2013) PMID 22704523

    Cerebral malaria (CM) is the most severe syndrome associated with Plasmodium falciparum infections. Experimental evidence suggests that disease results from the sequestration of parasitized-red blood cells (pRBCs) together with inflammatory leukocytes within brain capillaries. We have previously...
  10. Concurrent bacterial stimulation alters the function of helminth-activated dendritic cells, resulting in IL-17 induction.

    Journal of Immunology 188(5):2350 (2012) PMID 22287718 PMCID PMC3378507

    Infection with schistosome helminths is associated with granulomatous inflammation that forms around parasite eggs trapped in host tissues. In severe cases, the resulting fibrosis can lead to organ failure, portal hypertension, and fatal bleeding. Murine studies identified IL-17 as a critical me...
  11. Concurrent bacterial stimulation alters the function of helminth-activated dendritic cells, resulting in IL-17 induction.

    Journal of Immunology 188(5):2350 (2012) PMID 22287718 PMCID PMC3378507

    Infection with schistosome helminths is associated with granulomatous inflammation that forms around parasite eggs trapped in host tissues. In severe cases, the resulting fibrosis can lead to organ failure, portal hypertension, and fatal bleeding. Murine studies identified IL-17 as a critical me...
  12. Antigen presentation in immunity to murine malaria.

    Current Opinion in Immunology 23(1):119 (2011) PMID 20951016

    Understanding the initiation of cellular immune responses during blood-stage malaria infection is essential for the development of an effective vaccine that improves upon the naturally acquired immune response and induces rapid and long-lasting protection against disease. Recent studies have ide...
  13. Antigen presentation in immunity to murine malaria

    Current Opinion in Immunology 23(1):119 (2011) PMID 20951016

    Understanding the initiation of cellular immune responses during blood-stage malaria infection is essential for the development of an effective vaccine that improves upon the naturally acquired immune response and induces rapid and long-lasting protection against disease. Recent studie...
  14. Antigen presentation in immunity to murine malaria

    Current Opinion in Immunology 23(1):119 (2011)

    Understanding the initiation of cellular immune responses during blood-stage malaria infection is essential for the development of an effective vaccine that improves upon the naturally acquired immune response and induces rapid and long-lasting protection against disease. Recent studies hav...
  15. PS2-024. Dissecting the Response of Dendritic Cell Subsets to the Parasitic Helminth Schistosoma mansoni

    Cytokine 56(1):69 (2011)

  16. CS17-6. A role for plasmacytoid dendritic cells in Th2 response induction against helminths

    Cytokine 56(1):108 (2011)

  17. CS17-6. A role for plasmacytoid dendritic cells in Th2 response induction against helminths

    Cytokine 56(1):108 (2011)

  18. Antigen presentation in immunity to murine malaria

    Current Opinion in Immunology 23(1):119 (2011) PMID 20951016

    Understanding the initiation of cellular immune responses during blood-stage malaria infection is essential for the development of an effective vaccine that improves upon the naturally acquired immune response and induces rapid and long-lasting protection against disease. Recent studies hav...
  19. CD11c depletion severely disrupts Th2 induction and development in vivo.

    Journal of Experimental Medicine 207(10):2089 (2010) PMID 20819926 PMCID PMC2947067

    Although dendritic cells (DCs) are adept initiators of CD4(+) T cell responses, their fundamental importance in this regard in Th2 settings remains to be demonstrated. We have used CD11c-diphtheria toxin (DTx) receptor mice to deplete CD11c(+) cells during the priming stage of the CD4(+) Th2 res...
  20. CD11c depletion severely disrupts Th2 induction and development in vivo.

    Journal of Experimental Medicine 207(10):2089 (2010) PMID 20819926 PMCID PMC2947067

    Although dendritic cells (DCs) are adept initiators of CD4(+) T cell responses, their fundamental importance in this regard in Th2 settings remains to be demonstrated. We have used CD11c-diphtheria toxin (DTx) receptor mice to deplete CD11c(+) cells during the priming stage of the CD4(+) Th2 res...