1. A polyaniline based ultrasensitive potentiometric immunosensor for cardiac troponin complex detection.

    Biosensors and Bioelectronics 72:100 (2015) PMID 25966464

    An ultrasensitive immunosensor based on potentiometric ELISA for the detection of a cardiac biomarker, troponin I-T-C (Tn I-T-C) complex, was developed. The sensor fabrication involves typical sandwich ELISA procedures, while the final signal readout was achieved using open circuit potentiometry...
  2. A carbon needle microelectrode decorated with TiO2 nanosheets dominated by reactive facets as a highly electrocatalytic sensing element.

    Talanta 143:184 (2015) PMID 26078147

    We demonstrate a highly efficient electrocatalytic activity of TiO2 nanosheets with reactive (001) facets grown on a carbon needle microelectrode (TiO2-CNE). This microelectrode is prepared by a simple hydrothermal process. Scanning electron microscopy, high-resolution transmission electron micr...
  3. Electrochemical detection of nitrate in PM2.5 with a copper-modified carbon fiber micro-disk electrode.

    Talanta 143:245 (2015) PMID 26078156

    The accurate measurement of nitrate in PM2.5 is essential for a complete understanding of the effects of aerosols on human health, the impact of aerosols on the radiative balance of the earth and the role of aerosols in visibility problems. In this paper, we present a novel, quick, easy, cheap a...
  4. Development of reverse transcription loop-mediated isothermal amplification assays to detect Hantaan virus and Seoul virus.

    Journal of Virological Methods 221:68 (2015) PMID 25920565

    We developed two assays based on one-step reverse transcription loop-mediated isothermal amplification (RT-LAMP) to identify Hantaan virus (HTNV) and Seoul virus (SEOV), members of the Hantavirus genus that cause hemorrhagic fever with renal syndrome (HFRS). Our results showed that these assays ...
  5. Quantification of carotid plaque elasticity and intraplaque neovascularization using contrast-enhanced ultrasound and image registration-based elastography.

    Ultrasonics 62:253 (2015) PMID 26074459

    It is valuable for evaluation of carotid plaque vulnerability to investigate the relation between intraplaque neovascularization (IPN) and plaque elasticity. The contrast-enhanced ultrasound (CEUS) has been used in IPN measurement, but it cannot assess plaque elasticity. The aim of this study wa...
  6. Distribution and Photochemistry of Polycyclic Aromatic Hydrocarbons in the Baotou Section of the Yellow River During Winter.

    Archives of Environmental Contamination and Tox... 69(2):133 (2015) PMID 25838210

    In this study, ice and water samples were collected from seven sites along the Baotou section of the Yellow River during winter 2013. Total polycyclic aromatic hydrocarbon (PAH) concentrations in the ice and in the water under the ice ranged from 21.3 to 59.4 ng L(-1), and from 38.3 to 222.4 ng ...
  7. From a binary salt to salt co-crystals of antibacterial agent lomefloxacin with improved solubility and bioavailability.

    Acta crystallographica Section B, Structural sc... 71(Pt 4):437 (2015) PMID 26208624

    The cocrystallization of lomefloxacin (Lf) with barbituric acid (HBA) and/or isophthalic acid (H2ip) leads to novel binary and ternary salts via hydrogen-bonding recognition. X-ray single-crystal diffraction analyses show that zwitterionic lomefloxacin can adjust itself to fulfill a different su...
  8. Modeling and simulation of macro-fiber composite layered smart structures

    Composite Structures 126:89 (2015)

    Piezo fiber composite material, macro-fiber composite (MFC), is increasingly applied in engineering, due to its high flexibility and strong actuation forces. This paper develops a linear electro-mechanically coupled finite element (FE) model for composite laminated thin-walled smart st...
  9. Comparative Metagenomics of Eight Geographically Remote Terrestrial Hot Springs.

    Microbial Ecology 70(2):411 (2015) PMID 25712554

    Hot springs are natural habitats for thermophilic Archaea and Bacteria. In this paper, we present the metagenomic analysis of eight globally distributed terrestrial hot springs from China, Iceland, Italy, Russia, and the USA with a temperature range between 61 and 92 (∘)C and pH between 1.8 and ...
  10. A Stem Cell-Derived Platform for Studying Single Synaptic Vesicles in Dopaminergic Synapses.

    Stem Cells Translational Medicine 4(8):887 (2015) PMID 26025981

    : The exocytotic release of dopamine is one of the most characteristic but also one of the least appreciated processes in dopaminergic neurotransmission. Fluorescence imaging has yielded rich information about the properties of synaptic vesicles and the release of neurotransmitters in excitatory...
  11. Hydrogen-rich water protects against ischemic brain injury in rats by regulating calcium buffering proteins.

    Brain research 1615:129 (2015) PMID 25920370

    Hydrogen-rich water (HRW) has anti-oxidant activities, and it exerts neuroprotective effects during ischemia-reperfusion brain injury. Parvalbumin and hippocalcin are two calcium buffering proteins, which are involved in neuronal differentiation, maturation and apoptosis. The aim of this study w...
  12. Substrate-Tuned Catalysis of the Radical S-Adenosyl-L-Methionine Enzyme NosL Involved in Nosiheptide Biosynthesis.

    Angewandte Chemie. International edition in Eng... 54(31):9021 (2015) PMID 26138750

    NosL is a radical S-adenosyl-L-methionine (SAM) enzyme that converts L-Trp to 3-methyl-2-indolic acid, a key intermediate in the biosynthesis of a thiopeptide antibiotic nosiheptide. In this work we investigated NosL catalysis by using a series of Trp analogues as the molecular probes. Using a b...
  13. Two-Dimensional Layered Heterostructures Synthesized from Core-Shell Nanowires.

    Angewandte Chemie. International edition in Eng... 54(31):8957 (2015) PMID 26118436

    Controlled stacking of different two-dimensional (2D) atomic layers will greatly expand the family of 2D materials and broaden their applications. A novel approach for synthesizing MoS2 /WS2 heterostructures by chemical vapor deposition has been developed. The successful synthesis of pristine Mo...
  14. Substrate-Controlled Stereochemistry in Natural Product Biosynthesis.

    ACS Chemical Biology 10(7):1590 (2015) PMID 25844528

    Enzymes are generally believed to be highly regio- and stereoselective catalysts that strictly control the reaction coordinates and dominate the final catalytic outcomes. However, recent studies have started to suggest that substrates sometimes play key roles in determining the product selectivi...
  15. Structure of human MDM2 complexed with RPL11 reveals the molecular basis of p53 activation.

    Genes & Development 29(14):1524 (2015) PMID 26220995

    The central region of MDM2 is critical for p53 activation and tumor suppression. Upon ribosomal stress, this region is bound by ribosomal proteins, particularly ribosomal protein L11 (RPL11), leading to MDM2 inactivation and subsequent p53 activation. Here, we solved the complex structure of hum...
  16. DMAP-Catalyzed [2 + 4] Cycloadditions of Allenoates with N-Acyldiazenes: Direct Method to 1,3,4-Oxadiazine Derivatives.

    Organic Letters 17(13):3272 (2015) PMID 26061012

    An efficient DMAP-catalyzed [2 + 4] cycloaddition of allenoates and N-acyldiazenes is reported. The reaction involved embedding three heteroatoms into a six-membered ring and generated 1,3,4-oxadiazine derivatives in moderate to good yields.
  17. Rapid determination of trans-resveratrol in vegetable oils using magnetic hydrophilic multi-walled carbon nanotubes as adsorbents followed by liquid chromatography-tandem mass spectrometry.

    Food Chemistry 178:259 (2015) PMID 25704710

    In the present work, a rapid and simple procedure was developed and validated for the analysis of trans-resveratrol in vegetable oils based on magnetic hydrophilic multi-walled carbon nanotubes (h-MWCNT-MNPs) combined with liquid chromatography-tandem mass spectrometry (LC-MS/MS). h-MWCNT-MNPs w...
  18. A pre-clinical pharmacokinetic study in rats of three naturally occurring iridoid glycosides, Picroside-I, II and III, using a validated simultaneous HPLC-MS/MS assay.

    Journal of Chromatography B 993-994:47 (2015) PMID 25984965

    A selective and sensitive high-performance liquid chromatography-electro-spray ionization tandem mass spectrometry (LC-ESI-MS/MS) method was developed for the simultaneous quantitative determination of Picroside-I, II, and III in rat plasma and tissue homogenate to aid the pre-clinical studies. ...
  19. Isolation, identification and differentiation of human embryonic cartilage stem cells.

    Cell Biology International 39(7):777 (2015) PMID 26086409

    We isolated human embryonic cartilage stem cells (hECSCs), a novel stem cell population, from the articular cartilage of eight-week-old human embryos. These stem cells demonstrated a marker expression pattern and differentiation potential intermediate to those of human embryonic stem cells (hESC...
  20. A serum microRNA classifier for early detection of hepatocellular carcinoma: a multicentre, retrospective, longitudinal biomarker identification study with a nested case-control study.

    The Lancet Oncology 16(7):804 (2015) PMID 26088272

    The ability of circulating microRNAs (miRNAs) to detect preclinical hepatocellular carcinoma has not yet been reported. We aimed to identify and assess a serum miRNA combination that could detect the presence of clinical and preclinical hepatocellular carcinoma in at-risk patients. We did a thre...