1. Influence of sex hormones and phytoestrogens on heart disease in men and women.

    Women's Health 6(1):77 (2010) PMID 20088732 PMCID PMC2836937

    Cardiovascular disease (CVD) is the number one cause of morbidity and mortality in men and women worldwide. According to the WHO, by 2015, almost 20 million people will die from CVD each year. It is well established that men and women differ not only in baseline cardiac parameters, but also in t...
  2. Threonine-5 at the N-terminus can modulate sarcolipin function in cardiac myocytes.

    Journal of Molecular and Cellular Cardiology 47(5):723 (2009) PMID 19631655 PMCID PMC2843622

    Sarcolipin (SLN) has emerged as an important regulator of the atrial sarcoplasmic reticulum (SR) Ca2+ transport. The inhibitory effect of SLN on cardiac SR Ca2+ ATPase (SERCA) pump can be relieved by beta-adrenergic stimulation, which indicates that SLN is a reversible inhibitor. However, the me...
  3. Regulation of sarcoplasmic reticulum Ca2+ ATPase pump expression and its relevance to cardiac muscle physiology and pathology.

    Cardiovascular Research 77(2):265 (2008) PMID 18006443

    Cardiac sarcoplasmic reticulum (SR) Ca(2+) ATPase (SERCA2a) plays a central role in myocardial contractility. SERCA2a actively transports Ca(2+) into the SR and regulates cytosolic Ca(2+) concentration, SR Ca(2+) load, and the rate of contraction and relaxation of the heart. In the heart, SERCA ...
  4. Ablation of sarcolipin enhances sarcoplasmic reticulum calcium transport and atrial contractility.

    PNAS 104(45):17867 (2007) PMID 17971438 PMCID PMC2077025

    Sarcolipin is a novel regulator of cardiac sarcoplasmic reticulum Ca2+ ATPase 2a (SERCA2a) and is expressed abundantly in atria. In this study we investigated the physiological significance of sarcolipin in the heart by generating a mouse model deficient for sarcolipin. The sarcolipin-null mice ...
  5. Expression of SERCA isoform with faster Ca2+ transport properties improves postischemic cardiac function and Ca2+ handling and decreases myocardial infarction.

    American Journal of Physiology - Heart and Circ... 293(4):H2418 (2007) PMID 17630344

    Myocardial ischemia-reperfusion (I/R) injury is associated with contractile dysfunction, arrhythmias, and myocyte death. Intracellular Ca(2+) overload with reduced activity of sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA) is a critical mechanism of this injury. Although upregulation of SERC...
  6. Differential expression of sarcolipin protein during muscle development and cardiac pathophysiology.

    Journal of Molecular and Cellular Cardiology 43(2):215 (2007) PMID 17561107 PMCID PMC2706541

    Sarcolipin (SLN) is a small molecular weight sarcoplasmic reticulum (SR) membrane protein expressed both in cardiac and skeletal muscle tissues. Recent studies using transgenic mouse models have demonstrated that SLN is an important regulator of cardiac SR Ca2+ ATPase 2a (SERCA2a). However, ther...
  7. Sarcolipin and phospholamban as regulators of cardiac sarcoplasmic reticulum Ca2+ ATPase.

    Journal of Molecular and Cellular Cardiology 42(5):903 (2007) PMID 17442337 PMCID PMC2743185

    The cardiac sarcoplasmic reticulum calcium ATPase (SERCA2a) plays a critical role in maintaining the intracellular calcium homeostasis during cardiac contraction and relaxation. It has been well documented over the years that altered expression and activity of SERCA2a can lead to systolic and di...
  8. Sarcolipin and phospholamban as regulators of cardiac sarcoplasmic reticulum Ca2+ATPase

    Journal of Molecular and Cellular Cardiology 42(5):903 (2007)

    The cardiac sarcoplasmic reticulum calcium ATPase (SERCA2a) plays a critical role in maintaining the intracellular calcium homeostasis during cardiac contraction and relaxation. It has been well documented over the years that altered expression and activity of SERCA2a can lead to systolic a...
  9. Targeted overexpression of sarcolipin in the mouse heart decreases sarcoplasmic reticulum calcium transport and cardiac contractility.

    Journal of Biological Chemistry 281(7):3972 (2006) PMID 16365042

    The role of sarcolipin (SLN) in cardiac physiology was critically evaluated by generating a transgenic (TG) mouse model in which the SLN to sarco(endoplasmic)reticulum (SR) Ca(2+) ATPase (SERCA) ratio was increased in the ventricle. Overexpression of SLN decreases SR calcium transport function a...
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