1. Sequencing the mouse y chromosome reveals convergent gene acquisition and amplification on both sex chromosomes.

    Cell 159(4):800 (2014) PMID 25417157 PMCID PMC4260969

    We sequenced the MSY (male-specific region of the Y chromosome) of the C57BL/6J strain of the laboratory mouse Mus musculus. In contrast to theories that Y chromosomes are heterochromatic and gene poor, the mouse MSY is 99.9% euchromatic and contains about 700 protein-coding genes. Only 2% of th...
  2. Sequencing the mouse Y chromosome reveals convergent gene acquisition and amplification on both sex chromosomes.

    Cell 159(4):800 (2014) PMID 25417157 PMCID PMC4260969

    We sequenced the MSY (male-specific region of the Y chromosome) of the C57BL/6J strain of the laboratory mouse Mus musculus. In contrast to theories that Y chromosomes are heterochromatic and gene poor, the mouse MSY is 99.9% euchromatic and contains about 700 protein-coding genes. Only 2% of th...
  3. Lipin-1 and lipin-3 together determine adiposity in vivo.

    Molecular Metabolism 3(2):145 (2014) PMID 24634820 PMCID PMC3953701

    The lipin protein family of phosphatidate phosphatases has an established role in triacylglycerol synthesis and storage. Physiological roles for lipin-1 and lipin-2 have been identified, but the role of lipin-3 has remained mysterious. Using lipin single- and double-knockout models we identified...
  4. Lipin-1 and lipin-3 together determine adiposityin vivo

    Molecular Metabolism 3(2):145 (2014) PMID 24634820 PMCID PMC3953701

    The lipin protein family of phosphatidate phosphatases has an established role in triacylglycerol synthesis and storage. Physiological roles for lipin-1 and lipin-2 have been identified, but the role of lipin-3 has remained mysterious. Using lipin single- and double-knockout models we ...
  5. Lipin-1 and lipin-3 together determine adiposityin vivo

    Molecular Metabolism 3(2):145 (2014)

    The lipin protein family of phosphatidate phosphatases has an established role in triacylglycerol synthesis and storage. Physiological roles for lipin-1 and lipin-2 have been identified, but the role of lipin-3 has remained mysterious. Using lipin single- and double-knockout models we ...
  6. Lipin-1 and lipin-3 together determine adiposityin vivo

    Molecular Metabolism 3(2):145 (2014) PMID 24634820 PMCID PMC3953701

    The lipin protein family of phosphatidate phosphatases has an established role in triacylglycerol synthesis and storage. Physiological roles for lipin-1 and lipin-2 have been identified, but the role of lipin-3 has remained mysterious. Using lipin single- and double-knockout models we ...
  7. Efficient de novo assembly of large and complex genomes by massively parallel sequencing of Fosmid pools.

    BMC Genomics 15:439 (2014) PMID 24906298 PMCID PMC4070561

    Sampling genomes with Fosmid vectors and sequencing of pooled Fosmid libraries on the Illumina platform for massive parallel sequencing is a novel and promising approach to optimizing the trade-off between sequencing costs and assembly quality. In order to sequence the genome of Norway spruce, w...
  8. Efficient de novo assembly of large and complex genomes by massively parallel sequencing of Fosmid pools.

    BMC Genomics 15:439 (2014) PMID 24906298 PMCID PMC4070561

    Sampling genomes with Fosmid vectors and sequencing of pooled Fosmid libraries on the Illumina platform for massive parallel sequencing is a novel and promising approach to optimizing the trade-off between sequencing costs and assembly quality. In order to sequence the genome of Norway spruce, w...
  9. Efficient de novo assembly of large and complex genomes by massively parallel sequencing of Fosmid pools.

    BMC Genomics 15:439 (2014) PMID 24906298 PMCID PMC4070561

    Sampling genomes with Fosmid vectors and sequencing of pooled Fosmid libraries on the Illumina platform for massive parallel sequencing is a novel and promising approach to optimizing the trade-off between sequencing costs and assembly quality. In order to sequence the genome of Norway spruce, w...
  10. Response to glucocorticoids at 2 weeks predicts the effectiveness of DMARD induction therapy at 3 months: post hoc analyses from the tREACH study.

    Annals of the Rheumatic Diseases 72(10):1659 (2013) PMID 23117243

    To investigate if a glucocorticoid (GC) response at 2 weeks, defined by EULAR response criteria, can predict active disease (Disease Activity Score (DAS)>2.4) at 3 months. For this study, data of the Treatment in the Rotterdam Early Arthritis Cohort study (tREACH), an ongoing clinical trial that...
  11. The Norway spruce genome sequence and conifer genome evolution.

    Nature 497(7451):579 (2013) PMID 23698360

    Conifers have dominated forests for more than 200 million years and are of huge ecological and economic importance. Here we present the draft assembly of the 20-gigabase genome of Norway spruce (Picea abies), the first available for any gymnosperm. The number of well-supported genes (28,354) is ...
  12. The Norway spruce genome sequence and conifer genome evolution.

    Nature 497(7451):579 (2013) PMID 23698360

    Conifers have dominated forests for more than 200 million years and are of huge ecological and economic importance. Here we present the draft assembly of the 20-gigabase genome of Norway spruce (Picea abies), the first available for any gymnosperm. The number of well-supported genes (28,354) is ...
  13. Insights into bilaterian evolution from three spiralian genomes.

    Nature 493(7433):526 (2013) PMID 23254933 PMCID PMC4085046

    Current genomic perspectives on animal diversity neglect two prominent phyla, the molluscs and annelids, that together account for nearly one-third of known marine species and are important both ecologically and as experimental systems in classical embryology. Here we describe the draft genomes ...
  14. Insights into bilaterian evolution from three spiralian genomes.

    Nature 493(7433):526 (2013) PMID 23254933 PMCID PMC4085046

    Current genomic perspectives on animal diversity neglect two prominent phyla, the molluscs and annelids, that together account for nearly one-third of known marine species and are important both ecologically and as experimental systems in classical embryology. Here we describe the draft genomes ...
  15. An in-depth characterization of the major psoriasis susceptibility locus identifies candidate susceptibility alleles within an HLA-C enhancer element.

    PLoS ONE 8(8):e71690 (2013) PMID 23990973 PMCID PMC3747202

    Psoriasis is an immune-mediated skin disorder that is inherited as a complex genetic trait. Although genome-wide association scans (GWAS) have identified 36 disease susceptibility regions, more than 50% of the genetic variance can be attributed to a single Major Histocompatibility Complex (MHC) ...
  16. An in-depth characterization of the major psoriasis susceptibility locus identifies candidate susceptibility alleles within an HLA-C enhancer element.

    PLoS ONE 8(8):e71690 (2013) PMID 23990973 PMCID PMC3747202

    Psoriasis is an immune-mediated skin disorder that is inherited as a complex genetic trait. Although genome-wide association scans (GWAS) have identified 36 disease susceptibility regions, more than 50% of the genetic variance can be attributed to a single Major Histocompatibility Complex (MHC) ...
  17. Sphingosine-1-phosphate lyase expression in embryonic and adult murine tissues.

    Journal of Lipid Research 53(9):1920 (2012) PMID 22781001 PMCID PMC3413231

    Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid involved in immunity, inflammation, angiogenesis, and cancer. S1P lyase (SPL) is the essential enzyme responsible for S1P degradation. SPL augments apoptosis and is down-regulated in cancer. SPL generates a S1P chemical gradient that prom...
  18. Sphingosine-1-phosphate lyase expression in embryonic and adult murine tissues.

    Journal of Lipid Research 53(9):1920 (2012) PMID 22781001 PMCID PMC3413231

    Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid involved in immunity, inflammation, angiogenesis, and cancer. S1P lyase (SPL) is the essential enzyme responsible for S1P degradation. SPL augments apoptosis and is down-regulated in cancer. SPL generates a S1P chemical gradient that prom...
  19. The chimpanzee GH locus: composition, organization, and evolution.

    Mammalian Genome 23(5-6):387 (2012) PMID 22290452

    In most mammals the growth hormone (GH) locus comprises a single gene expressed primarily in the anterior pituitary gland. However, in higher primates multiple duplications of the GH gene gave rise to a complex locus containing several genes. In man this locus comprises five genes, including GH-...
  20. The chimpanzee GH locus: composition, organization, and evolution.

    Mammalian Genome 23(5-6):387 (2012) PMID 22290452

    In most mammals the growth hormone (GH) locus comprises a single gene expressed primarily in the anterior pituitary gland. However, in higher primates multiple duplications of the GH gene gave rise to a complex locus containing several genes. In man this locus comprises five genes, including GH-...