1. CD8 T cells and dendritic cells: key players in the attenuated maternal immune response to influenza infection.

    Journal of Reproductive Immunology 107:1 (2015) PMID 25453203

    Pregnancy provides a unique challenge for maternal immunity, requiring the ability to tolerate the presence of a semi-allogeneic foetus, and yet still being capable of inducing an immune response against invading pathogens. To achieve this, numerous changes must occur in the activity and functio...
  2. CD8 T cells and dendritic cells: key players in the attenuated maternal immune response to influenza infection.

    Journal of Reproductive Immunology 107:1 (2015) PMID 25453203

    Pregnancy provides a unique challenge for maternal immunity, requiring the ability to tolerate the presence of a semi-allogeneic foetus, and yet still being capable of inducing an immune response against invading pathogens. To achieve this, numerous changes must occur in the activity and functio...
  3. Differential injurious effects of ambient and traffic-derived particulate matter on airway epithelial cells.

    Respirology 20(1):73 (2015) PMID 25219656

    Exposure to airborne particulate matter (PM) may promote development of childhood asthma and trigger acute exacerbations of existing asthma via injury to airway epithelial cells (AEC). We compared the response of AEC to ambient particulates with median aerodynamic diameters of <10 μm or <2.5 μm ...
  4. The placental protein syncytin-1 impairs antiviral responses and exaggerates inflammatory responses to influenza.

    PLoS ONE 10(4):e0118629 (2015) PMID 25831059 PMCID PMC4382184

    Pregnancy increases susceptibility to influenza. The placenta releases an immunosuppressive endogenous retroviral protein syncytin-1. We hypothesised that exposure of peripheral monocytes (PBMCs) to syncytin-1 would impair responses to H1N1pdm09 influenza. Recombinant syncytin-1 was produced. PB...
  5. Differential injurious effects of ambient and traffic-derived particulate matter on airway epithelial cells.

    Respirology 20(1):73 (2015) PMID 25219656

    Exposure to airborne particulate matter (PM) may promote development of childhood asthma and trigger acute exacerbations of existing asthma via injury to airway epithelial cells (AEC). We compared the response of AEC to ambient particulates with median aerodynamic diameters of <10 μm or <2.5 μm ...
  6. Differential injurious effects of ambient and traffic-derived particulate matter on airway epithelial cells.

    Respirology 20(1):73 (2015) PMID 25219656

    Exposure to airborne particulate matter (PM) may promote development of childhood asthma and trigger acute exacerbations of existing asthma via injury to airway epithelial cells (AEC). We compared the response of AEC to ambient particulates with median aerodynamic diameters of <10 μm or <2.5 μm ...
  7. The interaction between mother and fetus and the development of allergic asthma.

    Expert Review of Respiratory Medicine 8(1):57 (2014) PMID 24409981

    The rising prevalence of asthma and atopic disease in industrialized countries in the last 50 years has raised important questions about how and why the disease develops in susceptible populations. Most asthma begins in childhood in association with allergic sensitization and the development of ...
  8. The interaction between mother and fetus and the development of allergic asthma.

    Expert Review of Respiratory Medicine 8(1):57 (2014) PMID 24409981

    The rising prevalence of asthma and atopic disease in industrialized countries in the last 50 years has raised important questions about how and why the disease develops in susceptible populations. Most asthma begins in childhood in association with allergic sensitization and the development of ...
  9. Plasmacytoid dendritic cells and CD8 T cells from pregnant women show altered phenotype and function following H1N1/09 infection.

    Journal of Infectious Diseases 208(7):1062 (2013) PMID 23861550

    Pregnant women are a high-risk group during influenza pandemics. In this study we determined whether plasmacytoid dendritic cells (pDCs) and CD8 T cells from pregnant women display altered activity following in vitro infection with 2009 pandemic swine influenza (H1N1/09). Peripheral blood mononu...
  10. Plasmacytoid dendritic cells and CD8 T cells from pregnant women show altered phenotype and function following H1N1/09 infection.

    Journal of Infectious Diseases 208(7):1062 (2013) PMID 23861550

    Pregnant women are a high-risk group during influenza pandemics. In this study we determined whether plasmacytoid dendritic cells (pDCs) and CD8 T cells from pregnant women display altered activity following in vitro infection with 2009 pandemic swine influenza (H1N1/09). Peripheral blood mononu...
  11. A prospective study of respiratory viral infection in pregnant women with and without asthma.

    Chest 144(2):420 (2013) PMID 23493968

    Respiratory viral infections are common in pregnancy, but their health impact, especially in asthma, is unknown. The objective of this study was to assess the frequency, severity, and consequences of respiratory viral infection during pregnancy in women with and without asthma. In this prospecti...
  12. A prospective study of respiratory viral infection in pregnant women with and without asthma.

    Chest 144(2):420 (2013) PMID 23493968

    Respiratory viral infections are common in pregnancy, but their health impact, especially in asthma, is unknown. The objective of this study was to assess the frequency, severity, and consequences of respiratory viral infection during pregnancy in women with and without asthma. In this prospecti...
  13. Viral and bacterial infection in acute asthma and chronic obstructive pulmonary disease increases the risk of readmission.

    Respirology 18(6):996 (2013) PMID 23600594

    Infection is as an important trigger for acute asthma and chronic obstructive pulmonary disease (COPD). The aim of this article was to determine the prevalence and impact of virus and bacterial infections in acute asthma and COPD. Subjects were recruited, within 24 h of hospital admission for ac...
  14. Viral and bacterial infection in acute asthma and chronic obstructive pulmonary disease increases the risk of readmission.

    Respirology 18(6):996 (2013) PMID 23600594

    Infection is as an important trigger for acute asthma and chronic obstructive pulmonary disease (COPD). The aim of this article was to determine the prevalence and impact of virus and bacterial infections in acute asthma and COPD. Subjects were recruited, within 24 h of hospital admission for ac...
  15. Alterations in inflammatory, antiviral and regulatory cytokine responses in peripheral blood mononuclear cells from pregnant women with asthma.

    Respirology 18(5):827 (2013) PMID 23421904

    Severe asthma exacerbations during pregnancy are a common complication leading to poor health outcomes for both the mother and the baby. Asthma exacerbations are caused most frequently by respiratory viruses. A balance between antiviral and inflammatory immune responses is critical during pregna...
  16. Alterations in inflammatory, antiviral and regulatory cytokine responses in peripheral blood mononuclear cells from pregnant women with asthma.

    Respirology 18(5):827 (2013) PMID 23421904

    Severe asthma exacerbations during pregnancy are a common complication leading to poor health outcomes for both the mother and the baby. Asthma exacerbations are caused most frequently by respiratory viruses. A balance between antiviral and inflammatory immune responses is critical during pregna...
  17. The E3 ubiquitin ligase midline 1 promotes allergen and rhinovirus-induced asthma by inhibiting protein phosphatase 2A activity.

    Nature Medicine 19(2):232 (2013) PMID 23334847

    Allergic airway inflammation is associated with activation of innate immune pathways by allergens. Acute exacerbations of asthma are commonly associated with rhinovirus infection. Here we show that, after exposure to house dust mite (HDM) or rhinovirus infection, the E3 ubiquitin ligase midline ...
  18. The E3 ubiquitin ligase midline 1 promotes allergen and rhinovirus-induced asthma by inhibiting protein phosphatase 2A activity.

    Nature Medicine 19(2):232 (2013) PMID 23334847

    Allergic airway inflammation is associated with activation of innate immune pathways by allergens. Acute exacerbations of asthma are commonly associated with rhinovirus infection. Here we show that, after exposure to house dust mite (HDM) or rhinovirus infection, the E3 ubiquitin ligase midline ...
  19. Novel immune genes associated with excessive inflammatory and antiviral responses to rhinovirus in COPD.

    Respiratory Research 14:15 (2013) PMID 23384071 PMCID PMC3570361

    Rhinovirus (RV) is a major cause of chronic obstructive pulmonary disease (COPD) exacerbations, and primarily infects bronchial epithelial cells. Immune responses from BECs to RV infection are critical in limiting viral replication, and remain unclear in COPD. The objective of this study is to i...
  20. Novel immune genes associated with excessive inflammatory and antiviral responses to rhinovirus in COPD.

    Respiratory Research 14:15 (2013) PMID 23384071 PMCID PMC3570361

    Rhinovirus (RV) is a major cause of chronic obstructive pulmonary disease (COPD) exacerbations, and primarily infects bronchial epithelial cells. Immune responses from BECs to RV infection are critical in limiting viral replication, and remain unclear in COPD. The objective of this study is to i...