1. Mature T cell responses are controlled by microRNA-142.

    Journal of Clinical Investigation 125(7):2825 (2015) PMID 26098216

    T cell proliferation is critical for immune responses; however, the molecular mechanisms that mediate the proliferative response are poorly understood. MicroRNAs (miRs) regulate various molecular processes, including development and function of the immune system. Here, utilizing multiple complem...
  2. Allogeneic transplantation with myeloablative FluBu4 conditioning improves survival compared to reduced intensity FluBu2 conditioning for acute myeloid leukemia in remission.

    Annals of Hematology 94(6):1033 (2015) PMID 25784222

    The optimal intensity of conditioning for allogeneic hematopoietic stem cell transplantation (HCT) in acute myeloid leukemia (AML) remains undefined. Traditionally, myeloablative conditioning regimens improve disease control, but at the risk of greater nonrelapse mortality. Because fludarabine w...
  3. Sugar polymers exacerbate lung GVHD.

    Blood 125(19):2883 (2015) PMID 25953978

    In this issue of Blood, Uryu et al demonstrate that recognition of a fungal cell wall component, α-mannan (Mn), an Mn (sugar) polymer, by the C-type lectin receptor Dectin-2 on host macrophages leads to a lung chemokine environment conducive to donor T helper (Th)17 accumulation resulting in sev...
  4. BET bromodomain inhibition suppresses graft-versus-host disease after allogeneic bone marrow transplantation in mice.

    Blood 125(17):2724 (2015) PMID 25778533 PMCID PMC4408296

    Acute graft-versus-host disease (GVHD) is the major obstacle of allogeneic bone marrow transplantation (BMT). Bromodomain and extra-terminal (BET) protein inhibitors selectively block acetyl-binding pockets of the bromodomains and modulate histone acetylation. Here, we report that inhibition of ...
  5. Lung parenchyma-derived IL-6 promotes IL-17A-dependent acute lung injury after allogeneic stem cell transplantation.

    Blood 125(15):2435 (2015) PMID 25673640

    Idiopathic pneumonia syndrome (IPS) is a relatively common, frequently fatal clinical entity, characterized by noninfectious acute lung inflammation following allogeneic stem cell transplantation (SCT), the mechanisms of which are unclear. In this study, we demonstrate that immune suppression wi...
  6. Early Post-Transplant Notch Signaling Activity Is Critical for the Differentiation of Pathogenic Alloantigen-Specific T Cells Mediating Acute Graft-Versus-Host Disease

    Biology of Blood and Marrow Transplantation 21(2):S348 (2015)

  7. Histone deacetylase inhibition regulates inflammation and enhances Tregs after allogeneic hematopoietic cell transplantation in humans.

    Blood 125(5):815 (2015) PMID 25428224 PMCID PMC4311228

    We examined immunological responses in patients receiving histone deacetylase (HDAC) inhibition (vorinostat) for graft-versus-host disease prophylaxis after allogeneic hematopoietic cell transplant. Vorinostat treatment increased histone acetylation in peripheral blood mononuclear cells (PBMCs) ...
  8. Histone deacetylase inhibition regulates inflammation and enhances Tregs after allogeneic hematopoietic cell transplantation in humans.

    Blood 125(5):815 (2015) PMID 25428224 PMCID PMC4311228

    We examined immunological responses in patients receiving histone deacetylase (HDAC) inhibition (vorinostat) for graft-versus-host disease prophylaxis after allogeneic hematopoietic cell transplant. Vorinostat treatment increased histone acetylation in peripheral blood mononuclear cells (PBMCs) ...
  9. 188: Lung parenchyma-derived IL-6 promotes IL-17A-dependent acute lung injury after allogeneic stem cell transplantation

    Cytokine 70(1):73 (2014)

    Idiopathic Pneumonia Syndrome (IPS) is a relatively common, frequently fatal clinical entity characterized by non-infectious acute lung inflammation following allogeneic stem cell transplantation (SCT), the mechanisms of which are unclear. Here we demonstrate that immune suppression wi...
  10. Participation in clinical research: perspectives of adult patients and parents of pediatric patients undergoing hematopoietic stem cell transplantation.

    Biology of Blood and Marrow Transplantation 20(10):1604 (2014) PMID 24972252 PMCID PMC4163094

    Despite major improvements over the past several decades, many patients undergoing hematopoietic stem cell transplantations (HSCT) continue to suffer from significant treatment-related morbidity and mortality. Clinical research studies (trials) have been integral to advancing the standard of car...
  11. Participation in clinical research: perspectives of adult patients and parents of pediatric patients undergoing hematopoietic stem cell transplantation.

    Biology of Blood and Marrow Transplantation 20(10):1604 (2014) PMID 24972252 PMCID PMC4163094

    Despite major improvements over the past several decades, many patients undergoing hematopoietic stem cell transplantations (HSCT) continue to suffer from significant treatment-related morbidity and mortality. Clinical research studies (trials) have been integral to advancing the standard of car...
  12. Proteasome: target for acute and chronic GVHD?

    Blood 124(10):1551 (2014) PMID 25190753 PMCID PMC4155267

  13. Proteasome: target for acute and chronic GVHD?

    Blood 124(10):1551 (2014) PMID 25190753 PMCID PMC4155267

  14. Etanercept plus topical corticosteroids as initial therapy for grade one acute graft-versus-host disease after allogeneic hematopoietic cell transplantation.

    Biology of Blood and Marrow Transplantation 20(9):1426 (2014) PMID 24892263 PMCID PMC4145722

    Clinical diagnosis of grade 1 acute graft-versus-host disease (GVHD) marks the beginning of a potentially progressive and fatal course of GVHD after hematopoietic stem cell transplantation (HSCT). However, interventional studies to treat early GVHD are lacking. We conducted a single-arm prospect...
  15. Engraftment syndrome after allogeneic hematopoietic cell transplantation predicts poor outcomes.

    Biology of Blood and Marrow Transplantation 20(9):1407 (2014) PMID 24892262 PMCID PMC4142041

    Engraftment syndrome (ES), characterized by fever, rash, pulmonary edema, weight gain, liver and renal dysfunction, and/or encephalopathy, occurs at the time of neutrophil recovery after hematopoietic cell transplantation (HCT). In this study, we evaluated the incidence, clinical features, risk ...
  16. Etanercept plus Topical Corticosteroids as Initial Therapy for Grade One Acute Graft-Versus-Host Disease after Allogeneic Hematopoietic Cell Transplantation

    Biology of Blood and Marrow Transplantation 20(9):1426 (2014)

    Clinical diagnosis of grade 1 acute graft-versus-host disease (GVHD) marks the beginning of a potentially progressive and fatal course of GVHD after hematopoietic stem cell transplantation (HSCT). However, interventional studies to treat early GVHD are lacking. We conducted a single-ar...
  17. Current and emerging strategies for the prevention of graft-versus-host disease.

    Nature Reviews Clinical Oncology 11(9):536 (2014) PMID 24958183 PMCID PMC4151470

    Graft-versus-host disease (GVHD) represents the most serious and challenging complication of allogeneic haematopoietic stem-cell transplantation (HSCT). New insights on the role of regulatory T-cells, T cells, and antigen-presenting cells have led to an improved understanding of the pathophysiol...
  18. Current and emerging strategies for the prevention of graft-versus-host disease.

    Nature Reviews Clinical Oncology 11(9):536 (2014) PMID 24958183 PMCID PMC4151470

    Graft-versus-host disease (GVHD) represents the most serious and challenging complication of allogeneic haematopoietic stem-cell transplantation (HSCT). New insights on the role of regulatory T-cells, T cells, and antigen-presenting cells have led to an improved understanding of the pathophysiol...
  19. The difficulty in diagnosing cord colitis.

    Biology of Blood and Marrow Transplantation 20(7):906 (2014) PMID 24838030

  20. The Difficulty in Diagnosing Cord Colitis

    Biology of Blood and Marrow Transplantation 20(7):906 (2014)