1. Case records of the Massachusetts General Hospital. Case 12-2015. A newborn boy with respiratory distress, lethargy, and hypernatremia.

    New England Journal of Medicine 372(16):1550 (2015) PMID 25875261

  2. Reversal and relapse of hypogonadotropic hypogonadism: resilience and fragility of the reproductive neuroendocrine system.

    Journal of Clinical Endocrinology & Metabolism 99(3):861 (2014) PMID 24423288 PMCID PMC3942233

    A subset of patients diagnosed with idiopathic hypogonadotropic hypogonadism (IHH) later achieves activation of their hypothalamic-pituitary-gonadal axis with normalization of steroidogenesis and/or gametogenesis, a phenomenon termed reversal. The objective of this study was to determine the nat...
  3. Reversal and relapse of hypogonadotropic hypogonadism: resilience and fragility of the reproductive neuroendocrine system.

    Journal of Clinical Endocrinology & Metabolism 99(3):861 (2014) PMID 24423288 PMCID PMC3942233

    A subset of patients diagnosed with idiopathic hypogonadotropic hypogonadism (IHH) later achieves activation of their hypothalamic-pituitary-gonadal axis with normalization of steroidogenesis and/or gametogenesis, a phenomenon termed reversal. The objective of this study was to determine the nat...
  4. Trial of recombinant follicle-stimulating hormone pretreatment for GnRH-induced fertility in patients with congenital hypogonadotropic hypogonadism.

    Journal of Clinical Endocrinology & Metabolism 98(11):E1790 (2013) PMID 24037890 PMCID PMC3816270

    The optimal strategy for inducing fertility in men with congenital hypogonadotropic hypogonadism (CHH) is equivocal. Albeit a biologically plausible approach, pretreatment with recombinant FSH (rFSH) before GnRH/human chorionic gonadotropin administration has not been sufficiently assessed. The ...
  5. Trial of recombinant follicle-stimulating hormone pretreatment for GnRH-induced fertility in patients with congenital hypogonadotropic hypogonadism.

    Journal of Clinical Endocrinology & Metabolism 98(11):E1790 (2013) PMID 24037890 PMCID PMC3816270

    The optimal strategy for inducing fertility in men with congenital hypogonadotropic hypogonadism (CHH) is equivocal. Albeit a biologically plausible approach, pretreatment with recombinant FSH (rFSH) before GnRH/human chorionic gonadotropin administration has not been sufficiently assessed. The ...
  6. Metabolic effects of Roux-en-Y gastric bypass in obese adolescents and young adults.

    Journal of Pediatric Gastroenterology and Nutri... 56(5):528 (2013) PMID 23274343 PMCID PMC3637417

    Weight loss surgery is an increasingly common treatment option for obese adolescents, but data are limited regarding the metabolic effects of surgical weight loss procedures. We performed a retrospective review of the electronic medical record to determine metabolic outcomes for 24 adolescents a...
  7. Metabolic effects of Roux-en-Y gastric bypass in obese adolescents and young adults.

    Journal of Pediatric Gastroenterology and Nutri... 56(5):528 (2013) PMID 23274343 PMCID PMC3637417

    Weight loss surgery is an increasingly common treatment option for obese adolescents, but data are limited regarding the metabolic effects of surgical weight loss procedures. We performed a retrospective review of the electronic medical record to determine metabolic outcomes for 24 adolescents a...
  8. A genetic basis for functional hypothalamic amenorrhea.

    New England Journal of Medicine 364(3):215 (2011) PMID 21247312 PMCID PMC3045842

    Functional hypothalamic amenorrhea is a reversible form of gonadotropin-releasing hormone (GnRH) deficiency commonly triggered by stressors such as excessive exercise, nutritional deficits, or psychological distress. Women vary in their susceptibility to inhibition of the reproductive axis by su...
  9. A genetic basis for functional hypothalamic amenorrhea.

    New England Journal of Medicine 364(3):215 (2011) PMID 21247312 PMCID PMC3045842

    Functional hypothalamic amenorrhea is a reversible form of gonadotropin-releasing hormone (GnRH) deficiency commonly triggered by stressors such as excessive exercise, nutritional deficits, or psychological distress. Women vary in their susceptibility to inhibition of the reproductive axis by su...
  10. A genetic basis for functional hypothalamic amenorrhea.

    New England Journal of Medicine 364(3):215 (2011) PMID 21247312 PMCID PMC3045842

    Functional hypothalamic amenorrhea is a reversible form of gonadotropin-releasing hormone (GnRH) deficiency commonly triggered by stressors such as excessive exercise, nutritional deficits, or psychological distress. Women vary in their susceptibility to inhibition of the reproductive axis by su...
  11. Rathke's cleft cysts in children and adolescents: association with female puberty.

    Journal of Pediatric Endocrinology and Metabolism 23(11):1175 (2010) PMID 21284332

    There are few pediatric data regarding manifestations and outcomes of Rathke's cleft cysts (RCC). We retrospectively reviewed 13 cases treated at Massachusetts General Hospital over 10 years. Age at presentation was 12-17 years, except for one 7-year-old who presented with sexual precocity. Ther...
  12. Rathke's cleft cysts in children and adolescents: association with female puberty.

    Journal of Pediatric Endocrinology and Metabolism 23(11):1175 (2010) PMID 21284332

    There are few pediatric data regarding manifestations and outcomes of Rathke's cleft cysts (RCC). We retrospectively reviewed 13 cases treated at Massachusetts General Hospital over 10 years. Age at presentation was 12-17 years, except for one 7-year-old who presented with sexual precocity. Ther...
  13. Safety of frequent venous blood sampling in a pediatric research population.

    The Journal of Pediatrics 154(4):578 (2009) PMID 19026428 PMCID PMC2694723

    To monitor hematological indices in otherwise healthy children with central precocious puberty who underwent frequent venous sampling as part of a longitudinal clinical research study. Thirty-four female subjects underwent frequent venous sampling (every 10-20 minutes for 8-16 hours) every 6 mon...
  14. Adolescent obesity and bariatric surgery.

    Current Opinion in Endocrinology Diabetes and O... 16(1):37 (2009) PMID 19104236

    Examines the effects of bariatric surgery on adolescent obesity. The risks and outcomes of bariatric surgery in adolescence are presently being defined and may be somewhat different from those in adults. Adolescents may have a greater risk of weight regain, and greater risk of noncompliance to t...
  15. Adolescent obesity and bariatric surgery.

    Current Opinion in Endocrinology Diabetes and O... 16(1):37 (2009) PMID 19104236

    Examines the effects of bariatric surgery on adolescent obesity. The risks and outcomes of bariatric surgery in adolescence are presently being defined and may be somewhat different from those in adults. Adolescents may have a greater risk of weight regain, and greater risk of noncompliance to t...
  16. Role of seminiferous tubular development in determining the FSH versus LH responsiveness to GnRH in early sexual maturation.

    Neuroendocrinology 90(3):260 (2009) PMID 19829004 PMCID PMC2826435

    The onset of sexual maturation at puberty is a unique developmental period from a neuroendocrine perspective in that it is characterized by enhanced FSH secretion and FSH responsiveness to exogenous GnRH (vs. LH) from the gonadotrope, yet the mechanism of these dynamics remains unclear. This stu...
  17. Role of seminiferous tubular development in determining the FSH versus LH responsiveness to GnRH in early sexual maturation.

    Neuroendocrinology 90(3):260 (2009) PMID 19829004 PMCID PMC2826435

    The onset of sexual maturation at puberty is a unique developmental period from a neuroendocrine perspective in that it is characterized by enhanced FSH secretion and FSH responsiveness to exogenous GnRH (vs. LH) from the gonadotrope, yet the mechanism of these dynamics remains unclear. This stu...
  18. Safety of Frequent Venous Blood Sampling in a Pediatric Research Population

    The Journal of Pediatrics 154(4):578 (2009)

    Objective To monitor hematological indices in otherwise healthy children with central precocious puberty who underwent frequent venous sampling as part of a longitudinal clinical research study.
  19. The relative role of gonadal sex steroids and gonadotropin-releasing hormone pulse frequency in the regulation of follicle-stimulating hormone secretion in men.

    Journal of Clinical Endocrinology & Metabolism 93(7):2686 (2008) PMID 18445673 PMCID PMC2453056

    Our objective was to determine the importance of testosterone (T), estradiol (E(2)), and GnRH pulse frequency to FSH regulation in men. This was a prospective study with four arms. The study was performed at the General Clinical Research Center. There were 20 normal (NL) men and 15 men with idio...
  20. The relative role of gonadal sex steroids and gonadotropin-releasing hormone pulse frequency in the regulation of follicle-stimulating hormone secretion in men.

    Journal of Clinical Endocrinology & Metabolism 93(7):2686 (2008) PMID 18445673 PMCID PMC2453056

    Our objective was to determine the importance of testosterone (T), estradiol (E(2)), and GnRH pulse frequency to FSH regulation in men. This was a prospective study with four arms. The study was performed at the General Clinical Research Center. There were 20 normal (NL) men and 15 men with idio...