1. An S-Acylation Switch of Conserved G Domain Cysteines Is Required for Polarity Signaling by ROP GTPases

    Current Biology 25(21):2875 (2015)

  2. APP homodimers transduce an amyloid-β-mediated increase in release probability at excitatory synapses.

    Cell Reports 7(5):1560 (2014) PMID 24835997

    Accumulation of amyloid-β peptides (Aβ), the proteolytic products of the amyloid precursor protein (APP), induces a variety of synaptic dysfunctions ranging from hyperactivity to depression that are thought to cause cognitive decline in Alzheimer's disease. While depression of synaptic transmiss...
  3. Beclin 1 self-association is independent of autophagy induction by amino acid deprivation and rapamycin treatment.

    Journal of Cellular Biochemistry 110(5):1262 (2010) PMID 20564222

    Autophagy, a process of self-digestion of cellular constituents, regulates the balance between protein synthesis and protein degradation. Beclin 1 represents an important component of the autophagic machinery. It interacts with proteins that positively regulate autophagy, such as Vps34, UVRAG, a...
  4. An S-acylation switch of conserved G domain cysteines is required for polarity signaling by ROP GTPases.

    Current Biology 20(10):914 (2010) PMID 20451389

    Rho GTPases are master regulators of cell polarity. For their function, Rhos must associate with discrete plasma membrane domains. Rho of Plants (ROPs) or RACs comprise a single family. Prenylation and S-acylation of hypervariable domain cysteines of Ras and Rho GTPases are required for their fu...
  5. Differential interactions between Beclin 1 and Bcl-2 family members.

    Autophagy 3(6):561 (2007) PMID 17643073

    Autophagy, a cellular degradation system, promotes both cell death and survival. The interaction between Bcl-2 family proteins and Beclin 1, a Bcl-2 interacting protein that promotes autophagy, can mediate crosstalk between autophagy and apoptosis. We investigated the interaction between anti-an...