1. Global extent of chloroquine-resistant Plasmodium vivax - Authors' reply.

    The Lancet Infectious Diseases 15(6):630 (2015) PMID 26008832

  2. Surveillance of artemisinin resistance in Plasmodium falciparum in India using the kelch13 molecular marker.

    Antimicrobial Agents and Chemotherapy 59(5):2548 (2015) PMID 25691626 PMCID PMC4394795

    Malaria treatment in Southeast Asia is threatened with the emergence of artemisinin-resistant Plasmodium falciparum. Genome association studies have strongly linked a locus on P. falciparum chromosome 13 to artemisinin resistance, and recently, mutations in the kelch13 propeller region (Pfk-13) ...
  3. Treatment of Ebola.

    New England Journal of Medicine 372(17):1673 (2015) PMID 25901440

  4. Defining the in vivo phenotype of artemisinin-resistant falciparum malaria: a modelling approach.

    PLOS Medicine 12(4):e1001823 (2015) PMID 25919029 PMCID PMC4412633

    Artemisinin-resistant falciparum malaria has emerged in Southeast Asia, posing a major threat to malaria control. It is characterised by delayed asexual-stage parasite clearance, which is the reference comparator for the molecular marker 'Kelch 13' and in vitro sensitivity tests. However, curren...
  5. Plasma concentration of parasite DNA as a measure of disease severity in falciparum malaria.

    Journal of Infectious Diseases 211(7):1128 (2015) PMID 25344520

    In malaria-endemic areas, Plasmodium falciparum parasitemia is common in apparently healthy children and severe malaria is commonly misdiagnosed in patients with incidental parasitemia. We assessed whether the plasma Plasmodium falciparum DNA concentration is a useful datum for distinguishing un...
  6. Artemether-lumefantrine co-administration with antiretrovirals: population pharmacokinetics and dosing implications.

    British Journal of Clinical Pharmacology 79(4):636 (2015) PMID 25297720 PMCID PMC4386948

    Drug-drug interactions between antimalarial and antiretroviral drugs may influence antimalarial treatment outcomes. The aim of this study was to investigate the potential drug-drug interactions between the antimalarial drugs, lumefantrine, artemether and their respective metabolites desbutyl-lum...
  7. Plasma concentration of parasite DNA as a measure of disease severity in falciparum malaria.

    Journal of Infectious Diseases 211(7):1128 (2015) PMID 25344520 PMCID PMC4354984

    In malaria-endemic areas, Plasmodium falciparum parasitemia is common in apparently healthy children and severe malaria is commonly misdiagnosed in patients with incidental parasitemia. We assessed whether the plasma Plasmodium falciparum DNA concentration is a useful datum for distinguishing un...
  8. Evaluating clinical trial designs for investigational treatments of Ebola virus disease.

    PLOS Medicine 12(4):e1001815 (2015) PMID 25874579 PMCID PMC4397078

    Experimental treatments for Ebola virus disease (EVD) might reduce EVD mortality. There is uncertainty about the ability of different clinical trial designs to identify effective treatments, and about the feasibility of implementing individually randomised controlled trials during an Ebola epide...
  9. Spread of artemisinin-resistant Plasmodium falciparum in Myanmar: a cross-sectional survey of the K13 molecular marker.

    The Lancet Infectious Diseases 15(4):415 (2015) PMID 25704894 PMCID PMC4374103

    Emergence of artemisinin resistance in southeast Asia poses a serious threat to the global control of Plasmodium falciparum malaria. Discovery of the K13 marker has transformed approaches to the monitoring of artemisinin resistance, allowing introduction of molecular surveillance in remote areas...
  10. Independent emergence of artemisinin resistance mutations among Plasmodium falciparum in Southeast Asia.

    Journal of Infectious Diseases 211(5):670 (2015) PMID 25180241 PMCID PMC4334802

    The emergence of artemisinin-resistant Plasmodium falciparum in Southeast Asia threatens malaria treatment efficacy. Mutations in a kelch protein encoded on P. falciparum chromosome 13 (K13) have been associated with resistance in vitro and in field samples from Cambodia. P. falciparum infection...
  11. Genetic architecture of artemisinin-resistant Plasmodium falciparum.

    Nature Genetics 47(3):226 (2015) PMID 25599401

    We report a large multicenter genome-wide association study of Plasmodium falciparum resistance to artemisinin, the frontline antimalarial drug. Across 15 locations in Southeast Asia, we identified at least 20 mutations in kelch13 (PF3D7_1343700) affecting the encoded propeller and BTB/POZ domai...
  12. Genetic architecture of artemisinin-resistant Plasmodium falciparum.

    Nature Genetics 47(3):226 (2015) PMID 25599401

    We report a large multicenter genome-wide association study of Plasmodium falciparum resistance to artemisinin, the frontline antimalarial drug. Across 15 locations in Southeast Asia, we identified at least 20 mutations in kelch13 (PF3D7_1343700) affecting the encoded propeller and BTB/POZ domai...
  13. Independent Emergence of Artemisinin Resistance Mutations Among Plasmodium falciparum in Southeast Asia.

    Journal of Infectious Diseases 211(5):670 (2015) PMID 25180241 PMCID PMC4334802

    The emergence of artemisinin-resistant Plasmodium falciparum in Southeast Asia threatens malaria treatment efficacy. Mutations in a kelch protein encoded on P. falciparum chromosome 13 (K13) have been associated with resistance in vitro and in field samples from Cambodia. P. falciparum infection...
  14. Genetic architecture of artemisinin-resistant Plasmodium falciparum.

    Nature Genetics 47(3):226 (2015) PMID 25599401

    We report a large multicenter genome-wide association study of Plasmodium falciparum resistance to artemisinin, the frontline antimalarial drug. Across 15 locations in Southeast Asia, we identified at least 20 mutations in kelch13 (PF3D7_1343700) affecting the encoded propeller and BTB/POZ domai...
  15. Drug resistance. Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance.

    Science 347(6220):431 (2015) PMID 25502316

    Artemisinin resistance in Plasmodium falciparum threatens global efforts to control and eliminate malaria. Polymorphisms in the kelch domain-carrying protein K13 are associated with artemisinin resistance, but the underlying molecular mechanisms are unknown. We analyzed the in vivo transcriptome...
  16. Drug resistance. Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance.

    Science 347(6220):431 (2015) PMID 25502316

    Artemisinin resistance in Plasmodium falciparum threatens global efforts to control and eliminate malaria. Polymorphisms in the kelch domain-carrying protein K13 are associated with artemisinin resistance, but the underlying molecular mechanisms are unknown. We analyzed the in vivo transcriptome...
  17. Drug resistance. Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance.

    Science 347(6220):431 (2015) PMID 25502316

    Artemisinin resistance in Plasmodium falciparum threatens global efforts to control and eliminate malaria. Polymorphisms in the kelch domain-carrying protein K13 are associated with artemisinin resistance, but the underlying molecular mechanisms are unknown. We analyzed the in vivo transcriptome...
  18. Drug resistance. Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance.

    Science 347(6220):431 (2015) PMID 25502316

    Artemisinin resistance in Plasmodium falciparum threatens global efforts to control and eliminate malaria. Polymorphisms in the kelch domain-carrying protein K13 are associated with artemisinin resistance, but the underlying molecular mechanisms are unknown. We analyzed the in vivo transcriptome...
  19. Quality assurance of drugs used in clinical trials: proposal for adapting guidelines.

    British Medical Journal (Abstracts) 350:h602 (2015) PMID 25716700

  20. Intervals to Plasmodium falciparum recurrence after anti-malarial treatment in pregnancy: a longitudinal prospective cohort.

    Malaria Journal 14(1):221 (2015) PMID 26017553 PMCID PMC4449611

    Plasmodium falciparum infections adversely affect pregnancy. Anti-malarial treatment failure is common. The objective of this study was to examine the duration of persistent parasite carriage following anti-malarial treatment in pregnancy. The data presented here are a collation from previous st...